DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a2 and Cyp3a2

DIOPT Version :9

Sequence 1:	NP_523628.1	Gene:	Cyp6a2 / 35587	FlyBaseID:	FBgn0000473	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_695224.3	Gene:	Cyp3a2 / 266682	RGDID:	708379	Length:	504	Species:	Rattus norvegicus

Alignment Length:	495	Identity:	162/495 - (32%)
Similarity:	263/495 - (53%)	Gaps:	30/495 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 YLLIAISSLLAYLY----HRNFNYWNRRGVPHDAPHPLYGNMVGFRKNRVMHDFFYDYYNKYRKS 66
            ::|:|:  :|..||    ||: ..:.::|:|...|.|..|.::.:.|.  :..|..:.|.||.|
  Rat    12 WVLLAV--ILVLLYRLGTHRH-GIFKKQGIPGPKPLPFLGTVLNYYKG--LGRFDMECYKKYGK- 70

  Fly    67 GFPFVGFYFLHKPAAFIVDTQLAKNILIKD-FSNFADRGQFHNGRDDPLTQHLFNLDGKKWKDMR 130
               ..|.:....|...|:||::.||:|:|: ||.|.:|..|  |....:.:.:.....::||..|
  Rat    71 ---IWGLFDGQTPVFAIMDTEMIKNVLVKECFSVFTNRRDF--GPVGIMGKAVSVAKDEEWKRYR 130

  Fly   131 QRLTPTFTSGKMKFMFPTVIKVSEEFVKVITEQVPAAQNGAVLEIKELMARFTTDVIGTCAFGIE 195
            ..|:||||||::|.|||.:.:..:..||.:.::   |:.|..:.:|::...::.|||.:.:||:.
  Rat   131 ALLSPTFTSGRLKEMFPIIEQYGDILVKYLKQE---AETGKPVTMKKVFGAYSMDVITSTSFGVN 192

  Fly   196 CNTLRTPVSDFRTMGQKVFT-DMRHGKLLTMFVFSF-PKLASRLRMRMMPEDVHQFFMRLVNDTI 258
            .::|..|...|....:|:.. |......|::.:|.| ..:...|.:.|.|:|...||.:.|:...
  Rat   193 VDSLNNPKDPFVEKTKKLLRFDFFDPLFLSVVLFPFLTPIYEMLNICMFPKDSIAFFQKFVHRIK 257

  Fly   259 ALR-ERENFKRNDFMNLLIELKQKGRVTLDNGEVIEGMDIGELAAQVFVFYVAGFETSSSTMSYC 322
            ..| :.::..|.||:.|::......:..:.:    :.:...|:.||..:|..||:||:|||:|:.
  Rat   258 ETRLDSKHKHRVDFLQLMLNAHNNSKDEVSH----KALSDVEIIAQSVIFIFAGYETTSSTLSFV 318

  Fly   323 LYELAQNQDIQDRLRNEIQTVLEEQEGQLTYESIKAMTYLNQVISETLRLYTLVPHLERKALNDY 387
            ||.||.:.|||.:|:.||...| ..:...||:.:..|.||:.|::||||||.:...|||....|.
  Rat   319 LYFLATHPDIQKKLQEEIDGAL-PSKAPPTYDIVMEMEYLDMVLNETLRLYPIGNRLERVCKKDI 382

  Fly   388 VVPGHEKLVIEKGTQVIIPACAYHRDEDLYPNPETFDPERFSPEKVAARESVEWLPFGDGPRNCI 452
            .:.|   |.|.||:.|.||..|.|.|...:|.||.|.|||||.|...:.:...:||||:||||||
  Rat   383 ELDG---LFIPKGSVVTIPTYALHHDPQHWPKPEEFHPERFSKENKGSIDPYVYLPFGNGPRNCI 444

  Fly   453 GMRFGQMQARIGLAQIISRFRVSVCDTTEIPLKYSPMSIV 492
            ||||..|..::.|.:::..|....|..|:||||.|..:|:
  Rat   445 GMRFALMNMKLALTKVLQNFSFQPCKETQIPLKLSRQAIL 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	p450	36..502	CDD:278495	153/461 (33%)
Cyp3a2	NP_695224.3	CYP3A	67..493	CDD:410743	147/435 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1960
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8924
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.870