Protein Alignment Cyp6a2 and CYP4X1

DIOPT Version :10

• Sequence 1: NP_523628.1
• Gene: Cyp6a2 / 35587
• FlyBaseID: FBgn0000473
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_828847.1
• Gene: CYP4X1 / 260293
• HGNCID: 20244
• Length: 509
• Species: Homo sapiens
• Alignment Length: 549
• Identity: 138/549 - (25%)
• Similarity: 240/549 - (43%)
• Gaps: 104/549 - (18%)

  Fly     2 FVLIYLLIAISSLLAYLYHRNFNYWNRRGVPHDAPHPLYGNMVGFRKNRVMHDFFYDYYNKYRKS 66
            ||....|..:.::..|| .|.....:.|..|....|...|:....:.:.:  :...:...||.::
Human    18 FVFCLALGLLQAIKLYL-RRQRLLRDLRPFPAPPTHWFLGHQKFIQDDNM--EKLEEIIEKYPRA 79

  Fly    67 GFPF-VGFYFLHKPAAF--IVDTQLAKNILIKDFSNFADRGQFHNGRDDPLTQHL--FN------ 120
             ||| :|.:     .||  |.|...||.:|               .|.||.:|:|  |:
Human    80 -FPFWIGPF-----QAFFCIYDPDYAKTLL---------------SRTDPKSQYLQKFSPPLLGK 123

  Fly   121 ----LDGKKWKDMRQRLTPTFTSGKMKFMFPTVIKVSEEFVKVIT---EQVPAAQNGAVLEIKEL 178
                |||.||...|:.|||.|....:|    ..|:|....||::.   |::.:.|:.:| |:.|.
Human   124 GLAALDGPKWFQHRRLLTPGFHFNILK----AYIEVMAHSVKMMLDKWEKICSTQDTSV-EVYEH 183

  Fly   179 MARFTTDVIGTCAFGIECNTLRTPVSD---------FRTMGQKVFTDMRHGKLLTMFVFSFPKLA 234
            :...:.|:|..|||..|.|.......|         .:.:..::::.:.|..::
Human   184 INSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDII----------- 237

  Fly   235 SRLRMRMMPEDVH-QFFMRLVN---DTIALRERENF-------------KRNDFMNLLIELKQKG 282
                .::.|:... |...|::|   ||| ::||:..             |..||:::::..|.
Human   238 ----FKLSPQGYRFQKLSRVLNQYTDTI-IQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKD-- 295

  Fly   283 RVTLDNGEVIEGMDIGELAAQVFVFYVAGFETSSSTMSYCLYELAQNQDIQDRLRNEIQTVLEEQ 347
                ::|.....:|:   .::|..|.:||.:|.::::|:.||.||.|.:.|:|.|.|::.:|.:
Human   296 ----ESGSSFSDIDV---HSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGD- 352

  Fly   348 EGQLTYESIKAMTYLNQVISETLRLYTLVPHLERKALNDYVVPGHEKLVIEKGTQVIIPACAYHR 412
            ...:|::.:..|:|....|.||.||...||.:.|........|  :...:..|..|::.....|.
Human   353 GSSITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFP--DGCTLPAGITVVLSIWGLHH 415

  Fly   413 DEDLYPNPETFDPERFSPEKVAARESVEWLPFGDGPRNCIGMRFGQMQARIGLAQIISRFRVSVC 477
            :..::.||:.|||.|||.|....|....:|||..|.|||||..|..::.::.:|.|:..|||:.
Human   416 NPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTP- 479

  Fly   478 DTTEIPLKYSPMSIVLGTVGGIYLRVERI 506
            |.|. ||.: |...:|....|:||.::::
Human   480 DPTR-PLTF-PNHFILKPKNGMYLHLKKL 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	CYP6-like	69..500	CDD:410679	123/474 (26%)
CYP4X1	NP_828847.1	CYP4B-like	66..502	CDD:410771	127/494 (26%)
		heme binding region	447..460		7/12 (58%)