Protein Alignment Cyp6a2 and Cyp3a23-3a1

DIOPT Version :10

• Sequence 1: NP_523628.1
• Gene: Cyp6a2 / 35587
• FlyBaseID: FBgn0000473
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_037237.2
• Gene: Cyp3a23-3a1 / 25642
• RGDID: 628626
• Length: 502
• Species: Rattus norvegicus
• Alignment Length: 500
• Identity: 156/500 - (31%)
• Similarity: 258/500 - (51%)
• Gaps: 36/500 - (7%)

  Fly     6 YLLIAISSLLAYLY-HRNFNYWNRRGVPHDAPHPLYGNMVGFRKNRVMHDFFYDYYNKYRKSGFP 69
            ::|:|:..:|.|.: .|....:.::|:|...|.|.:|.::.:...  :..|..:.:.||.|
  Rat    12 WVLLAVVLVLLYGFGTRTHGLFKKQGIPGPKPLPFFGTVLNYYMG--LWKFDVECHKKYGK---- 70

  Fly    70 FVGFYFLHKPAAFIVDTQLAKNILIKD-FSNFADRGQFHNGRDDPLTQHLFNLDGKKWKDMRQRL 133
            ..|.:....|...|.||::.||:|:|: ||.|.:|..|  |....:.:.:.....::||..|..|
  Rat    71 IWGLFDGQMPLFAITDTEMIKNVLVKECFSVFTNRRDF--GPVGIMGKAISVSKDEEWKRYRALL 133

  Fly   134 TPTFTSGKMKFMFPTVIKVSEEFVKVITEQVPAAQNGAVLEIKELMARFTTDVIGTCAFGIECNT 198
            :||||||::|.|||.:.:..:..||.:.:     :.|..:.:||:...::.|||.:.:||:..::
  Rat   134 SPTFTSGRLKEMFPVIEQYGDILVKYLRQ-----EKGKPVPVKEVFGAYSMDVITSTSFGVNVDS 193

  Fly   199 LRTPVSDFRTMGQKVF-TDMRHGKLLTMFVFSF-PKLASRLRMRMMPEDVHQFFMRLVNDTIALR 261
            |..|...|....:|:. .|......|::.:|.| ..:...|.:.|.|:|..:||.:.|     .|
  Rat   194 LNNPKDPFVEKAKKLLRIDFFDPLFLSVVLFPFLTPVYEMLNICMFPKDSIEFFKKFV-----YR 253

  Fly   262 ERE------NFKRNDFMNLLIELKQKGRVTLDNGEVIEGMDIGELAAQVFVFYVAGFETSSSTMS 320
            .:|      ...|.||:.|::......:    :.|....:...|:.||..:|..||:|.:|||:|
  Rat   254 MKETRLDSVQKHRVDFLQLMMNAHNDSK----DKESHTALSDMEITAQSIIFIFAGYEPTSSTLS 314

  Fly   321 YCLYELAQNQDIQDRLRNEIQTVLEEQEGQLTYESIKAMTYLNQVISETLRLYTLVPHLERKALN 385
            :.|:.||.:.|.|.:|:.||...| ..:...||:::..|.||:.|::||||||.:...|||....
  Rat   315 FVLHSLATHPDTQKKLQEEIDRAL-PNKAPPTYDTVMEMEYLDMVLNETLRLYPIGNRLERVCKK 378

  Fly   386 DYVVPGHEKLVIEKGTQVIIPACAYHRDEDLYPNPETFDPERFSPEKVAARESVEWLPFGDGPRN 450
            |..:.|   :.:.||:.|:||:.|.|||...:|.||.|.|||||.|...:.:...:||||:||||
  Rat   379 DVEING---VFMPKGSVVMIPSYALHRDPQHWPEPEEFRPERFSKENKGSIDPYVYLPFGNGPRN 440

  Fly   451 CIGMRFGQMQARIGLAQIISRFRVSVCDTTEIPLKYSPMSIVLGT 495
            ||||||..|..::.|.:::..|....|..|:||||.|...::..|
  Rat   441 CIGMRFALMNMKLALTKVLQNFSFQPCKETQIPLKLSRQGLLQPT 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	CYP6-like	69..500	CDD:410679	141/435 (32%)
Cyp3a23-3a1	NP_037237.2	CYP3A	67..491	CDD:410743	144/442 (33%)