DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a2 and erg5

DIOPT Version :9

Sequence 1:	NP_523628.1	Gene:	Cyp6a2 / 35587	FlyBaseID:	FBgn0000473	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_593788.2	Gene:	erg5 / 2542469	PomBaseID:	SPAC19A8.04	Length:	543	Species:	Schizosaccharomyces pombe

Alignment Length:	546	Identity:	126/546 - (23%)
Similarity:	221/546 - (40%)	Gaps:	120/546 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FVLIYLLIAISSLLAYLYHRNFNYWNRRG-VPHDAPH---PLYGNMVGFRKNRVMHDFFYDYYNK 62
            :.:.:.|:|:  .:||   ...:|..::| :|  .|.   |..|:.:...|..      ::.||.
pombe    29 WTICFALLAV--CIAY---DQISYQMQKGHIP--GPRFKIPFMGSFLDSMKPT------FEKYNA 80

  Fly    63 YRKSGFPFVGFYFLHKPAAFIVDTQLAKNILIKDFSN--------FADRGQFHNGRDDPLTQH-- 117
            ..::| |.......||......:..||:.||     |        ..|.|:       .:.:|
pombe    81 KWQTG-PLSCVSVFHKFVVIASERDLARKIL-----NSPSYVQPCVVDAGK-------KILKHTN 132

  Fly   118 -LFNLDGKKWKDMRQRLTPTFTSGKMKFMFPTVIKVSEEFVKVITEQVPAAQNGAVLEIKELMAR 181
             :| |||:...:.|:.|...||:..:....|....|..::.|   |.:..:::    :..:.|..
pombe   133 WVF-LDGRDHIEYRKGLNGLFTTRALASYLPAQEAVYNKYFK---EFLAHSKD----DYAQYMIP 189

  Fly   182 FTTDVIGT-----CAFGIECNTLRTPVSDFRTMGQKVFTDMRHGKLLTMF--VFSFPKLASRLRM 239
            |....:.|     |.:.|..:.::....::    .|:...|.    |..|  |..|.|:...::.
pombe   190 FRDINVATSCRTFCGYYISDDAIKHIADEY----WKITAAME----LVNFPIVLPFTKVWYGIQS 246

  Fly   240 RMMPEDVHQFFMRLVNDTIALRERENFK--------RNDFMNLLIELKQKGRVTLDNGE----VI 292
            |.:   |.::||:     .|...|:|.:        ..::::.:||.::......:..|    :|
pombe   247 RKV---VMRYFMK-----AAAESRKNMEAGNAPACMMEEWIHEMIETRKYKSENKEGAEKPSVLI 303

  Fly   293 EGMDIGELAAQVFVFYVAGFETSSSTMSYCLYELAQNQDIQDRLRNEIQTVLEEQEGQ----LTY 353
            ......|::.....|..|..:.:||.|::....||.:.|:..::|.|   .|..::|.    |:.
pombe   304 REFSDEEISLTFLSFLFASQDATSSAMTWLFQLLADHPDVLQKVREE---QLRIRKGDIDVPLSL 365

  Fly   354 ESIKAMTYLNQVISETLRL---YTLVPHLERKAL---NDYVVPGHEKLVIEKGTQVIIPACAYHR 412
            :.::.|||...|:.|.|||   ..:||:..:||.   .||.||        |...||........
pombe   366 DLMEKMTYTRAVVKECLRLRPPVLMVPYRVKKAFPITPDYTVP--------KDAMVIPTLYGALH 422

  Fly   413 DEDLYPNPETFDPERFSPEKVAARESVEWLPFGDGPRNCIGMRF--GQMQARIGLAQII---SRF 472
            |..:||.||||:|:|::|..:|.:....|:.||:||..|:|.|:  ..:.|.||.|.|:   ...
pombe   423 DSKVYPEPETFNPDRWAPNGLAEQSPKNWMVFGNGPHVCLGQRYAVNHLIACIGKASIMLDWKHK 487

  Fly   473 RVSVCDT-----TEIP-----LKYSP 488
            |....||     |..|     ||:||
pombe   488 RTPDSDTQMIFATTFPQDMCYLKFSP 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	p450	36..502	CDD:278495	119/511 (23%)
erg5	NP_593788.2	CypX	57..505	CDD:225035	115/501 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1773
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
TreeFam	0	0.000	Not matched by this tool.
	3	3.050