Protein Alignment Cyp6a2 and Cyp3a18

DIOPT Version :9

• Sequence 1: NP_523628.1
• Gene: Cyp6a2 / 35587
• FlyBaseID: FBgn0000473
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_665725.2
• Gene: Cyp3a18 / 252931
• RGDID: 628709
• Length: 497
• Species: Rattus norvegicus
• Alignment Length: 492
• Identity: 154/492 - (31%)
• Similarity: 260/492 - (52%)
• Gaps: 27/492 - (5%)

  Fly     6 YLLIAISSLLAYLYHR-NFNYWNRRGVPHDAPHPLYGNMVGFRKNRVMHDFFYDYYNKYRKSGFP 69
            ::|:|.|.:|.|:|.. :...:.:.|:|...|.||:|.:  |.....|..|..|.|.||.|
  Rat    12 WVLLATSLMLFYIYGTYSHGLFKKLGIPGPKPVPLFGTI--FNYGDGMWKFDDDCYKKYGK---- 70

  Fly    70 FVGFYFLHKPAAFIVDTQLAKNILIKD-FSNFADRGQFHNGRDDPLTQHLFNLDGKKWKDMRQRL 133
            ..|||...:|...|:|.::.|.:|:|: :|.|.:|..|  |....:.:.:...:.::||.:|..|
  Rat    71 IWGFYEGPQPFLAIMDPEIIKMVLVKECYSVFTNRRCF--GPMGFMKKAITMSEDEEWKRLRTIL 133

  Fly   134 TPTFTSGKMKFMFPTVIKVSEEFVKVITEQVPAAQNGAVLEIKELMARFTTDVIGTCAFGIECNT 198
            :|||||||:|.|||.:.:..:..:|.:..:   ...|..:.:|::...::.|||...:||:..::
  Rat   134 SPTFTSGKLKEMFPLMRQYGDTLLKNLRRE---EAKGEPINMKDIFGAYSMDVITGTSFGVNVDS 195

  Fly   199 LRTPVSDFRTMGQKVFT-DMRHGKLLTMFVFSF-PKLASRLRMRMMPEDVHQFFMRLVNDTIALR 261
            |..|...|....:|:.. .:....||::.:|.| ..:...|...:.|.....||.:.|......|
  Rat   196 LNNPQDPFVQKAKKILKFQIFDPFLLSVVLFPFLTPIYEMLNFSIFPRQSMNFFKKFVKTMKKNR 260

  Fly   262 ERENFK-RNDFMNLLIELK-QKGRVTLDNGEVIEGMDIGELAAQVFVFYVAGFETSSSTMSYCLY 324
            ...|.| |.||:.|::..: .||:      |..:.:...|:|||..:|...|::.:|:::|:.:|
  Rat   261 LDSNQKSRVDFLQLMMNTQNSKGQ------ESQKALSDLEMAAQAIIFIFGGYDATSTSISFIMY 319

  Fly   325 ELAQNQDIQDRLRNEIQTVLEEQEGQLTYESIKAMTYLNQVISETLRLYTLVPHLERKALNDYVV 389
            |||...::|.:|:|||...| ..:..:||:::..|.||:.|::|:||||.:...|:|.:..|..:
  Rat   320 ELATRPNVQKKLQNEIDRAL-PNKAPVTYDALMEMEYLDMVVNESLRLYPIATRLDRVSKKDVEI 383

  Fly   390 PGHEKLVIEKGTQVIIPACAYHRDEDLYPNPETFDPERFSPEKVAARESVEWLPFGDGPRNCIGM 454
            .|   :.|.|||.|.||....||:.:.:..||.|:|||||.|...:.:...:||||:||||||||
  Rat   384 NG---VFIPKGTVVTIPIYPLHRNPEYWLEPEEFNPERFSKENKGSIDPYVYLPFGNGPRNCIGM 445

  Fly   455 RFGQMQARIGLAQIISRFRVSVCDTTEIPLKYSPMSI 491
            ||..:..::.:..::..|.:..|:.|:||||.|...|
  Rat   446 RFALISMKLAVIGVLQNFNIQPCEKTQIPLKISRQPI 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	p450	36..502	CDD:278495	146/461 (32%)
Cyp3a18	NP_665725.2	CYP3A	67..492	CDD:410743	137/435 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1960
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8924
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.770