Protein Alignment Cyp6a2 and Cyp2j12

DIOPT Version :10

• Sequence 1: NP_523628.1
• Gene: Cyp6a2 / 35587
• FlyBaseID: FBgn0000473
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_001093652.1
• Gene: Cyp2j12 / 242546
• MGIID: 3717097
• Length: 502
• Species: Mus musculus
• Alignment Length: 489
• Identity: 109/489 - (22%)
• Similarity: 196/489 - (40%)
• Gaps: 113/489 - (23%)

  Fly    69 PFVGFYF---LHKPAAFIVDTQLAK---NILIKDFSN---------------FADRGQ-FHNGRD 111
            ||||..|   |.:|  .:|..|..|   |:...||.|               |.:..| |.|...
Mouse    51 PFVGNLFQLDLEQP--HVVIQQFVKKYGNLTSLDFGNIPSVIITGLPLIKEVFTNMEQNFLNRPI 113

  Fly   112 DPLTQHLFN------LDGKKWKDMRQRLTPT---FTSGKMKFMFPTVIKVSEEFVKVITEQVPAA 167
            .|:.:.:||      .:|:.||:.|:....|   |..|| |.:...:.|.::..|:.|.|
Mouse   114 TPIRKRVFNNNGLIISNGQTWKEQRRFALMTLKNFGLGK-KSLEQRIQKEADCLVEAIGE----- 172

  Fly   168 QNGAVLEIKELMARFTTDVIGTCAFG----------------------IECNTLRTPVSDFRTMG 210
            :.|...:....:....:::|.|.|||                      :|.:.:....:.|.::.
Mouse   173 EKGQPFDPHFKINSAVSNIICTFAFGERFEYEDSHFHELLRLLDEATCLEASMMCQLYNVFPSII 237

  Fly   211 QKV----FTDMRHGKLLTMFVFSFPKLASRLRMRMMPEDVHQFFMRLVNDTIALRER--ENFKRN 269
            |.|    .|.:|:.:.|.:|::   ::....|....|::...|....:.:.....::  .:|...
Mouse   238 QYVPGSHQTVLRNWEKLKLFIY---QMMESHRKDWNPDEPRDFIDAFLTEMSKYGDKTTTSFNEE 299

  Fly   270 DFMNLLIELKQKGRVTLDNGEVIEGMDIGELAAQVFVFYVAGFETSSSTMSYCLYELAQNQDIQD 334
            :.:|..::|                             :.||.||:::|:.:.|..:..|.::|:
Mouse   300 NLINSTLDL-----------------------------FFAGSETTTNTLRWALLYITTNPEVQE 335

  Fly   335 RLRNEIQTVLEEQEGQLTYESIKAMTYLNQVISETLRLYTLVP-HLERKALNDYVVPGHEKLVIE 398
            ::.:||..|:.... |.:.:...:|.|.|.||.|.||:..::| ::.|:...|..:.|..   :.
Mouse   336 KVHSEIDRVIGHGR-QPSTDDRDSMPYTNAVIHEVLRMGNILPMNVPREVTADSTLAGFH---LP 396

  Fly   399 KGTQVIIPACAYHRDEDLYPNPETFDPERFSPE-KVAARESVEWLPFGDGPRNCIGMRFGQMQAR 462
            |||.|:....|.|||...:..|.||:||.|... :...|||  :|||..|.|.|.|.:..:.:..
Mouse   397 KGTMVLTNLTALHRDPKEWATPNTFNPEHFLENGQFKKRES--FLPFSLGKRACPGEQLARSELF 459

  Fly   463 IGLAQIISRFRVSVCDTTEIPLKY------SPMS 490
            |....::.:|........::.||:      ||:|
Mouse   460 IFFTALMQKFTFKPPINEKLSLKFRNGLTLSPVS 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	CYP6-like	69..500	CDD:410679	109/489 (22%)
Cyp2j12	NP_001093652.1	cytochrome_P450	75..496	CDD:477761	99/463 (21%)