Protein Alignment Cyp6a2 and CYP4Z1

DIOPT Version :9

• Sequence 1: NP_523628.1
• Gene: Cyp6a2 / 35587
• FlyBaseID: FBgn0000473
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_835235.1
• Gene: CYP4Z1 / 199974
• HGNCID: 20583
• Length: 505
• Species: Homo sapiens
• Alignment Length: 559
• Identity: 145/559 - (25%)
• Similarity: 242/559 - (43%)
• Gaps: 125/559 - (22%)

  Fly     4 LIYLLIAISSLL---AYLYHRNFNYWNRRGV---PHDAPHPLYGNMVGFRKNRVMHDFFY----- 57
            |:.:|:.:|.||   ..||.|  ..|..|.:   |....|..||           |..||
Human    15 LLLILLCMSLLLFQVIRLYQR--RRWMIRALHLFPAPPAHWFYG-----------HKEFYPVKEF 66

  Fly    58 DYYNKYRKS---------GFPFVGFYFLHKP--AAFIVDTQLAKN-ILIKDFSNFADRGQFHNGR 110
            :.|:|..:.         | ||..|:.:|.|  |..::..|..|: :..|...::..||
Human    67 EVYHKLMEKYPCAVPLWVG-PFTMFFSVHDPDYAKILLKRQDPKSAVSHKILESWVGRG------ 124

  Fly   111 DDPLTQHLFNLDGKKWKDMRQRLTPTFTSGKMKFMFPTVIKVSEEFVKVITEQV---------PA 166
                   |..|||.|||..||.:.|.|.           |.:.:.|:.:::|.|         ..
Human   125 -------LVTLDGSKWKKHRQIVKPGFN-----------ISILKIFITMMSESVRMMLNKWEEHI 171

  Fly   167 AQNGAVLEIKELMARFTTDVIGTCAF----GIECNT-----LRTPVSDFRTMGQKVFTDMRHGKL 222
            |||.. ||:.:.::..|.|.|..|||    .|:.::     |:...:..:...|::...:.|..|
Human   172 AQNSR-LELFQHVSLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDL 235

  Fly   223 LTMFVFSFP---KLASRLRMRMMPEDVHQFFMRLVNDTIALRERENFK-----------RNDFMN 273
                ||.|.   ::.|:..     :::|||..:::.|     .:|:.|           |.||::
Human   236 ----VFKFSSQGQIFSKFN-----QELHQFTEKVIQD-----RKESLKDKLKQDTTQKRRWDFLD 286

  Fly   274 LLIELKQKGRVTLDNGEVIEGMDIGELAAQVFVFYVAGFETSSSTMSYCLYELAQNQDIQDRLRN 338
            :|:..|.:.  |.|..|       .:|.|:|..|..||.:|:||.:|:.||.||:..:.|.|.|:
Human   287 ILLSAKSEN--TKDFSE-------ADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRD 342

  Fly   339 EIQTVLEEQEGQLTYESIKAMTYLNQVISETLRLYTLVPHLERKALNDYVVPGHEKLVIEKGTQV 403
            ||:.:|.: ...:|:|.:..|.|....|.|.||||..|.::.|  |.|..:...:...:..|..|
Human   343 EIRELLGD-GSSITWEHLSQMPYTTMCIKECLRLYAPVVNISR--LLDKPITFPDGRSLPAGITV 404

  Fly   404 IIPACAYHRDEDLYPNPETFDPERFSPEKVAARESVEWLPFGDGPRNCIGMRFGQMQARIGLAQI 468
            .|...|.|.:...:.:|:.|:|.|||.|.........::||..|.|||||..|..::.::.:|..
Human   405 FINIWALHHNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALT 469

  Fly   469 ISRFRVSVCDTTEIPLKYSPM-SIVLGTVGGIYLRVERI 506
            :.||:::. |.:..|   .|: .:||.:..||::..:::
Human   470 LLRFKLAP-DHSRPP---QPVRQVVLKSKNGIHVFAKKV 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	p450	36..502	CDD:278495	134/515 (26%)
CYP4Z1	NP_835235.1	p450	47..500	CDD:278495	135/519 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810