DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a2 and Cyp6a16

DIOPT Version :9

Sequence 1:	NP_523628.1	Gene:	Cyp6a2 / 35587	FlyBaseID:	FBgn0000473	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_001285631.1	Gene:	Cyp6a16 / 19836250	FlyBaseID:	FBgn0031726	Length:	500	Species:	Drosophila melanogaster

Alignment Length:	513	Identity:	228/513 - (44%)
Similarity:	333/513 - (64%)	Gaps:	28/513 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FVLIYLLIAISSLLAYLYHRNFNYWNRRGVPHDAPHPLYGNMVGFRKNRVMH-DFFYDYYNKYRK 65
            |.|:.|...:|.||.||.:| |.||..||:|...||.|:|:.  ||...|.: :...:.|:.:|.
  Fly     3 FTLLLLTSLLSFLLGYLRYR-FTYWELRGIPQLRPHFLFGHF--FRLQSVHYSELLQETYDAFRG 64

  Fly    66 SGFPFVGFYFLHKPAAFIVDTQLAKNILIKDFSNFADRGQFHNGRDDPLTQHLFNLDGKKWKDMR 130
            |. ...|.|...:|.|.::|..|.|.:||:||:||.||..||.   ||||.:||||.|::|:::|
  Fly    65 SA-KVAGTYVFLRPMAVVLDLDLVKAVLIRDFNNFVDRRSFHG---DPLTANLFNLQGEEWRNLR 125

  Fly   131 QRLTPTFTSGKMKFMFPTVIKVSEEFVKVITEQVPAAQNGAVLEIKELMARFTTDVIGTCAFGIE 195
            .:|:|||||||||:||.||..|:::......|.|  ...|||||:.:||||:||||||:||||.|
  Fly   126 TKLSPTFTSGKMKYMFGTVSTVAQQLGGTFDELV--GSQGAVLELHDLMARYTTDVIGSCAFGTE 188

  Fly   196 CNTLRTPVSDFRTMGQKVFTDMRHG---KLLTM-FVFSFPKLASRLRMRMMPEDVHQFFMRLVND 256
            |::||.|.::||.:|:::|.:....   ::..| ::.|..||.  |.:|::..|:.:||.|:|.:
  Fly   189 CSSLREPQAEFRQVGRRIFRNSNRSIRWRIFKMTYLSSLAKLG--LPVRILHPDITKFFNRIVRE 251

  Fly   257 TIALRERENFKRNDFMNLLIELKQKGRVTLDNGEVIEGMDIGELAAQVFVFYVAGFETSSSTMSY 321
            |:.||||||.:|||||:||::|:::     :||   :|:.:.::|||.|||:|||||||||.|||
  Fly   252 TVELRERENIRRNDFMDLLLDLRRQ-----ENG---KGLTMEQMAAQAFVFFVAGFETSSSNMSY 308

  Fly   322 CLYELAQNQDIQDRLRNEIQTVLEEQEGQLTYESIKAMTYLNQVISETLRLYTLVPHLERKALND 386
            .|:|||:|||:|.:||.||...: .:.|:||||::..|.||:|.|:||||.|..:..|.|.|..|
  Fly   309 ALFELAKNQDVQQKLRMEINDSI-GKHGKLTYEAMMEMPYLDQTITETLRKYPALSSLTRLASED 372

  Fly   387 YVVP---GHEKLVIEKGTQVIIPACAYHRDEDLYPNPETFDPERFSPEKVAARESVEWLPFGDGP 448
            |.:|   |.:.:|:||||.|.||..|.|.|.::||.|..|.||||:|:....|....:|.|||||
  Fly   373 YEIPSPDGGDPVVLEKGTSVHIPVLAIHYDPEVYPEPHEFRPERFAPDACRERHPTAFLGFGDGP 437

  Fly   449 RNCIGMRFGQMQARIGLAQIISRFRVSVCDTTEIPLKYSPMSIVLGTVGGIYLRVERI 506
            |||||:|||:||.::||..::.|||.|:...:...||.:..:::|....|:.|:|:.:
  Fly   438 RNCIGLRFGRMQVKVGLITLLRRFRFSLPPGSPTQLKVTKRNLILLPSDGVRLQVDPV 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	p450	36..502	CDD:278495	211/473 (45%)
Cyp6a16	NP_001285631.1	p450	32..492	CDD:278495	213/478 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	9	8.970