DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a2 and Cyp3a9

DIOPT Version :9

Sequence 1:	NP_523628.1	Gene:	Cyp6a2 / 35587	FlyBaseID:	FBgn0000473	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_671739.2	Gene:	Cyp3a9 / 171352	RGDID:	708392	Length:	503	Species:	Rattus norvegicus

Alignment Length:	496	Identity:	166/496 - (33%)
Similarity:	262/496 - (52%)	Gaps:	33/496 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 YLLIAISSLLAYLY-HRNFNYWNRRGVPHDAPHPLYGNMVGFRKNRVMHDFFYDY----YNKYRK 65
            :||:.||.:|.||| ..:...:.:.|:|...|.|..|.::.:||.      |:::    :.||.|
  Rat    12 WLLLVISLVLLYLYGTHSHGIFKKLGIPGPKPLPFLGTILAYRKG------FWEFDKYCHKKYGK 70

  Fly    66 SGFPFVGFYFLHKPAAFIVDTQLAKNILIKD-FSNFADRGQFHNGRDDPLTQHLFNLDGKKWKDM 129
                ..|.|...:|...|.|..:.|.:|:|: :|.|.:|..|  |....|.:.:...:.::||.:
  Rat    71 ----LWGLYDGRQPVLAITDPDIIKTVLVKECYSTFTNRRNF--GPVGILKKAISISEDEEWKRI 129

  Fly   130 RQRLTPTFTSGKMKFMFPTVIKVSEEFVKVITEQVPAAQNGAVLEIKELMARFTTDVIGTCAFGI 194
            |..|:|||||||:|.|||.:.:.::..|:.:.:   .::.|....:|::...::.|||...:||:
  Rat   130 RALLSPTFTSGKLKEMFPIINQYTDMLVRNMRQ---GSEEGKPTSMKDIFGAYSMDVITATSFGV 191

  Fly   195 ECNTLRTPVSDFRTMGQKVFT-DMRHGKLLTMFVFSF-PKLASRLRMRMMPEDVHQFFMRLVNDT 257
            ..::|..|...|....:|:.. |:.....|::.:|.| ..|...|.:.|.|.||..||...|...
  Rat   192 NVDSLNNPQDPFVEKIKKLLKFDIFDPLFLSVTLFPFLTPLFEALNVSMFPRDVIDFFKTSVERM 256

  Fly   258 IALRERENFK-RNDFMNLLIELKQKGRVTLDNGEVIEGMDIGELAAQVFVFYVAGFETSSSTMSY 321
            ...|.:|..| |.||:.|:|. .|..:|. |:.:.:..:   |:.||..:|..||:||:||.:|:
  Rat   257 KENRMKEKEKQRMDFLQLMIN-SQNSKVK-DSHKALSDV---EIVAQSVIFIFAGYETTSSALSF 316

  Fly   322 CLYELAQNQDIQDRLRNEIQTVLEEQEGQLTYESIKAMTYLNQVISETLRLYTLVPHLERKALND 386
            .||.||.:.|||.:|::||...| ..:...||:::..|.||:.|::||||||.:...|||....|
  Rat   317 VLYLLAIHPDIQKKLQDEIDAAL-PNKAHATYDTLLQMEYLDMVVNETLRLYPIAGRLERVCKTD 380

  Fly   387 YVVPGHEKLVIEKGTQVIIPACAYHRDEDLYPNPETFDPERFSPEKVAARESVEWLPFGDGPRNC 451
            ..:.|   :.|.|||.|:||..|.|:|...:|.||.|.|||||.:.........:||||:|||||
  Rat   381 VEING---VFIPKGTVVMIPTFALHKDPHYWPEPEEFRPERFSKKNQDNINPYMYLPFGNGPRNC 442

  Fly   452 IGMRFGQMQARIGLAQIISRFRVSVCDTTEIPLKYSPMSIV 492
            |||||..|..::.|.:::..|....|..|:||||.|...::
  Rat   443 IGMRFALMNMKVALVRVLQNFSFQPCKETQIPLKLSKQGLL 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	p450	36..502	CDD:278495	156/465 (34%)
Cyp3a9	NP_671739.2	p450	39..493	CDD:278495	157/469 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1960
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8924
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.770