DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a2 and Cyp4f13

DIOPT Version :9

Sequence 1:	NP_523628.1	Gene:	Cyp6a2 / 35587	FlyBaseID:	FBgn0000473	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_570952.1	Gene:	Cyp4f13 / 170716	MGIID:	2158641	Length:	523	Species:	Mus musculus

Alignment Length:	534	Identity:	125/534 - (23%)
Similarity:	233/534 - (43%)	Gaps:	88/534 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ISSLLAYLYHRNFNYWNRRGVPHDAPHP--LYGNMVGFRKN--------RVMHDFFYDYYNKYRK 65
            ::.:||::|....|....|..| ..|.|  .:|::...:.|        .:.|| |:|.:..:..
Mouse    31 LARILAWIYAFYDNCSRLRCFP-QPPKPSWFWGHLALMKNNEESMQFITHLGHD-FHDVHLSWVG 93

  Fly    66 SGFPFVGFYF------LHKPAAFIVDTQLAKNILIKDFSNFADRGQFHNGRDDPLTQHLFNLDGK 124
            ..:|.:....      |.:.:|.:...::.....:|.:                |...|....|.
Mouse    94 PVYPILRLVHPNFIAPLLQASAAVAPKEMTLYGFLKPW----------------LGDGLLMSAGD 142

  Fly   125 KWKDMRQRLTPTFTSGKMKFMFPTVIKVSEEFVKVITE--QVPAAQNGAVLEIKELMARFTTDVI 187
            ||...|:.|||.|....:|    :.:|:..:.|.::..  |..|::..:.|::.|.::..|.|.:
Mouse   143 KWSHHRRLLTPAFHFDILK----SYVKIFNKSVNIMHAKWQCLASKGTSRLDMFEHISLMTLDSL 203

  Fly   188 GTCAFGIECNTLRT------PVSDFRTMGQKVFTDMRHGKLLTMFVFSFPKLASRLRMRMMPEDV 246
            ..|.|.::.|...:      .:.:..::..|     ||.:........:...|...|.|...:.|
Mouse   204 QKCIFSVDSNCQESDSKYIAAILELSSLVVK-----RHRQPFLYLDLLYYLTADGRRFRKACDLV 263

  Fly   247 HQFFMRLVNDTIALRERE---NFKRNDFMNLLIELKQKGRV-TLDNGEVI--------EGMDIGE 299
            |.|     .|.: ::||.   |.:..:|      ||.|.:. |||..:|:        :|:...:
Mouse   264 HNF-----TDAV-IKERRSTLNTQGVEF------LKAKAKTKTLDFIDVLLMAEDEHGKGLSNED 316

  Fly   300 LAAQVFVFYVAGFETSSSTMSYCLYELAQNQDIQDRLRNEIQTVLEEQEG-QLTYESIKAMTYLN 363
            :.|:...|...|.:|::|.:|:.||.||::.:.|:|.|.|:|.:|.:::. ::.::.:..:.:|.
Mouse   317 IRAEADTFMFGGHDTTTSALSWILYNLARHPEYQERCRQEVQELLRDRDSEEIEWDDLAQLPFLT 381

  Fly   364 QVISETLRLYTLVPHLERKALNDYVVPGHEKLVIEKGTQVIIPACAYHRDEDLYPNPETFDPERF 428
            ..|.|:|||:..|..:.|....|.::|  :...|.||...:|.....|.:..::|:||.::|.||
Mouse   382 MCIKESLRLHPPVLLISRCCTQDVLLP--DGRAIPKGNICVISIFGVHHNPSVWPDPEVYNPFRF 444

  Fly   429 SPEKVAARESVEWLPFGDGPRNCIGMRFGQMQARIGLAQIISRFRVSVCDTTEIPLKYSPM---S 490
            .||....|..:.::||..|.|||||..|...:.::.||..:.|||:       :|....|.   .
Mouse   445 DPENPQKRSPLAFIPFSAGTRNCIGQTFAMSEIKVALALTLLRFRI-------LPDDKEPRRKPE 502

  Fly   491 IVLGTVGGIYLRVE 504
            ::|...||::||||
Mouse   503 LILRAEGGLWLRVE 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	p450	36..502	CDD:278495	115/505 (23%)
Cyp4f13	NP_570952.1	p450	52..513	CDD:278495	116/508 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900