Protein Alignment Cyp6a2 and Cyp3a62

DIOPT Version :10

• Sequence 1: NP_523628.1
• Gene: Cyp6a2 / 35587
• FlyBaseID: FBgn0000473
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_001019403.1
• Gene: Cyp3a62 / 170509
• RGDID: 1595919
• Length: 497
• Species: Rattus norvegicus
• Alignment Length: 491
• Identity: 166/491 - (33%)
• Similarity: 260/491 - (52%)
• Gaps: 37/491 - (7%)

  Fly     6 YLLIAISSLLAYLY----HRNFNYWNRRGVPHDAPHPLYGNMVGFRKNRVMHDFFYDYYNKYRKS 66
            ::|:|...:|.|||    |.||   .:.|:....|.|..||::.:|     |.|:....:.::|.
  Rat    12 WMLLATILVLLYLYGTSTHGNF---KKLGISGPKPLPFVGNILAYR-----HGFWEFDRHCHKKY 68

  Fly    67 GFPFVGFYFLHKPAAFIVDTQLAKNILIKD-FSNFADRGQFHNGRDDPLTQHLFNLDGKKWKDMR 130
            | ...|||...:|...|.|..:.|.:|:|: :|.|.:|..|  |....|.:.:...:.::||.:|
  Rat    69 G-DIWGFYEGRQPILAITDPDIIKTVLVKECYSTFTNRRSF--GPAGILKKAITLSEDEEWKRLR 130

  Fly   131 QRLTPTFTSGKMKFMFPTVIKVSEEFVKVITEQVPAAQNGAVLEIKELMARFTTDVIGTCAFGIE 195
            ..|:|||||||:|.|||.:.:.::..||.:..:   |:.|..:.:|::...::.|||...:||:.
  Rat   131 TLLSPTFTSGKLKEMFPIINQYADLLVKNVKHE---AEKGNPITMKDIFGAYSMDVITGTSFGVN 192

  Fly   196 CNTLRTPVSDFRTMGQKVFTDMRHGKLLTMF--VFSFPKLA---SRLRMRMMPEDVHQFFMRLVN 255
            .::|..|.:.|   .|||...::...|...|  |..||.|.   ....:.:.|:||.:||...|.
  Rat   193 VDSLNNPQNPF---VQKVKKLLKFNFLDPFFLSVILFPFLTPVFEAFDITVFPKDVMKFFRTSVE 254

  Fly   256 DTIALRERENFK-RNDFMNLLIELKQKGRVTLDNGEVIEGMDIGELAAQVFVFYVAGFETSSSTM 319
            .....|.:|..| |.||:.|:|..:..|     :.|..:|:...|:.||...|..||:||:||.:
  Rat   255 RMKENRMQEKVKQRLDFLQLMINSQSSG-----DKESHQGLTDVEIVAQSIFFIFAGYETTSSAL 314

  Fly   320 SYCLYELAQNQDIQDRLRNEIQTVLEEQEGQLTYESIKAMTYLNQVISETLRLYTLVPHLERKAL 384
            |:.||.||.:.|:|.:|::||...| ..:..:||:.:..|.||:.|::|||||:.:...|||...
  Rat   315 SFALYLLATHPDLQKKLQDEIDAAL-PNKAPVTYDVLVEMEYLDMVLNETLRLFPVGGRLERVCK 378

  Fly   385 NDYVVPGHEKLVIEKGTQVIIPACAYHRDEDLYPNPETFDPERFSPEKVAARESVEWLPFGDGPR 449
            .|..:.|   :.|.|||.|::|..|.|:|...:|.||.|.||||..:...:.....:||||:|||
  Rat   379 KDVEING---VFIPKGTVVMVPTFALHKDPKCWPEPEEFCPERFRKKNQDSINPYIYLPFGNGPR 440

  Fly   450 NCIGMRFGQMQARIGLAQIISRFRVSVCDTTEIPLK 485
            |||||||..|..:|.|.:::..|...:|..|:||||
  Rat   441 NCIGMRFALMNMKIALVRVLQNFSFGLCKETQIPLK 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	CYP6-like	69..500	CDD:410679	147/424 (35%)
Cyp3a62	NP_001019403.1	CYP3A	67..492	CDD:410743	149/428 (35%)