Protein Alignment Cyp6a2 and CYP4A11

DIOPT Version :10

• Sequence 1: NP_523628.1
• Gene: Cyp6a2 / 35587
• FlyBaseID: FBgn0000473
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_000769.2
• Gene: CYP4A11 / 1579
• HGNCID: 2642
• Length: 519
• Species: Homo sapiens
• Alignment Length: 542
• Identity: 146/542 - (26%)
• Similarity: 244/542 - (45%)
• Gaps: 94/542 - (17%)

  Fly     3 VLIYLLIAISSLLAYLYHRNFNYWNRRGVPHDAPHPLYGNMVGFRKNRVMHDFFYDYYNKYRKSG 67
            :||.||:.|.::..|| ||.:.....:..|....|.|:|::...::::.:...     .|:.::
Human    24 LLILLLLLIKAVQLYL-HRQWLLKALQQFPCPPSHWLFGHIQELQQDQELQRI-----QKWVET- 81

  Fly    68 FPFVGFYFL--HKPAAFIVDTQLAKNILIKDFSNFADRGQFHNGRDDP------------LTQHL 118
            ||....::|  .|....:.|....|.||               ||.||            :...|
Human    82 FPSACPHWLWGGKVRVQLYDPDYMKVIL---------------GRSDPKSHGSYRFLAPWIGYGL 131

  Fly   119 FNLDGKKWKDMRQRLTPTFTSGKMK----FMFPTVIKVSEEFVKVITEQVPAAQNGAVLEIKELM 179
            ..|:|:.|...|:.|||.|....:|    .|..:|..:.:::.:::.:..|       ||:.:.:
Human   132 LLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSP-------LEVFQHV 189

  Fly   180 ARFTTDVIGTCAFG------IECNTLR--TPVSDFRTMGQKVFTDMRHGKLLTMFVFSFPKLASR 236
            :..|.|.|..|||.      ::.|:..  ..:||...:   ||:.:|:.......::|... |.|
Human   190 SLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNL---VFSRVRNAFHQNDTIYSLTS-AGR 250

  Fly   237 LRMRMMPEDVHQFFMRLVNDTIALR--------ERENFKRN---DFMNLLIELKQKGRVTLDNGE 290
            ...|.. :..||.    .:..|.||        |.|..||.   ||:::|:..|      ::||.
Human   251 WTHRAC-QLAHQH----TDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAK------MENGS 304

  Fly   291 VIEGMDIGELAAQVFVFYVAGFETSSSTMSYCLYELAQNQDIQDRLRNEIQTVLEEQEGQLTYES 355
            ::...|   |.|:|..|...|.:|::|.:|:.||.||.:...|:|.|.||.::|.: ...:|:..
Human   305 ILSDKD---LRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGD-GASITWNH 365

  Fly   356 IKAMTYLNQVISETLRLYTLVPHLERKALNDYVVPGHEKLVIEKGTQVIIPACAYHRDEDLYPNP 420
            :..|.|....|.|.||||..||.:.|:.......|....|  .||..|::.....|.:..::|||
Human   366 LDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSL--PKGIMVLLSIYGLHHNPKVWPNP 428

  Fly   421 ETFDPERFSPEKVAARESVEWLPFGDGPRNCIGMRFGQMQARIGLAQIISRFRVSVCDTTEIPLK 485
            |.|||.||:|.  :|:.|..:|||..|.|||||.:|...:.::..|..:.||.: :.|.|.||:
Human   429 EVFDPFRFAPG--SAQHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFEL-LPDPTRIPI- 489

  Fly   486 YSPMS-IVLGTVGGIYLRVERI 506
              |:: :||.:..||:||:.|:
Human   490 --PIARLVLKSKNGIHLRLRRL 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	CYP6-like	69..500	CDD:410679	127/468 (27%)
CYP4A11	NP_000769.2	CYP4B-like	74..505	CDD:410771	130/485 (27%)