DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cyp6a2 and CYP3A4

DIOPT Version :9

Sequence 1:NP_523628.1 Gene:Cyp6a2 / 35587 FlyBaseID:FBgn0000473 Length:506 Species:Drosophila melanogaster
Sequence 2:NP_059488.2 Gene:CYP3A4 / 1576 HGNCID:2637 Length:503 Species:Homo sapiens


Alignment Length:515 Identity:168/515 - (32%)
Similarity:265/515 - (51%) Gaps:46/515 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 YLLIAISSLLAYLY-HRNFNYWNRRGVPHDAPHPLYGNMVGFRKNRVMHDFFYDYYNKYRKSGFP 69
            :||:|:|.:|.||| ..:...:.:.|:|...|.|..||::.:.|...|.|.  :.:.||.|    
Human    12 WLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDM--ECHKKYGK---- 70

  Fly    70 FVGFYFLHKPAAFIVDTQLAKNILIKD-FSNFADRGQFHNGRDDPLTQHLFNLDGKKWKDMRQRL 133
            ..|||...:|...|.|..:.|.:|:|: :|.|.:|..|  |....:...:...:.::||.:|..|
Human    71 VWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPF--GPVGFMKSAISIAEDEEWKRLRSLL 133

  Fly   134 TPTFTSGKMKFMFPTVIKVSEEFVKVITEQVPAAQNGAVLEIKELMARFTTDVIGTCAFGIECNT 198
            :|||||||:|.|.|.:.:..:..|:.:..:   |:.|..:.:|::...::.|||.:.:||:..::
Human   134 SPTFTSGKLKEMVPIIAQYGDVLVRNLRRE---AETGKPVTLKDVFGAYSMDVITSTSFGVNIDS 195

  Fly   199 LRTPVSDFRTMGQKVFTDMRHGKL------LTMFVFSFPKLASRLRMRMMPEDVHQFFMRLVNDT 257
            |..|...|....:|:   :|...|      :|:|.|..| :...|.:.:.|.:|..|..:.|...
Human   196 LNNPQDPFVENTKKL---LRFDFLDPFFLSITVFPFLIP-ILEVLNICVFPREVTNFLRKSVKRM 256

  Fly   258 IALRERENFK-RNDFMNLLIELKQKGRVTLDNGEVIEGMDIGELAAQVFVFYVAGFETSSSTMSY 321
            ...|..:..| |.||:.|:|: .|..:.|    |..:.:...||.||..:|..||:||:||.:|:
Human   257 KESRLEDTQKHRVDFLQLMID-SQNSKET----ESHKALSDLELVAQSIIFIFAGYETTSSVLSF 316

  Fly   322 CLYELAQNQDIQDRLRNEIQTVLEEQEGQLTYESIKAMTYLNQVISETLRLYTLVPHLERKALND 386
            .:||||.:.|:|.:|:.||..|| ..:...||:::..|.||:.|::|||||:.:...|||....|
Human   317 IMYELATHPDVQQKLQEEIDAVL-PNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKD 380

  Fly   387 YVVPGHEKLVIEKGTQVIIPACAYHRDEDLYPNPETFDPERFSPEKVAARESVEWLPFGDGPRNC 451
            ..:.|   :.|.||..|:||:.|.|||...:..||.|.|||||.:.....:...:.|||.|||||
Human   381 VEING---MFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNC 442

  Fly   452 IGMRFGQMQARIGLAQIISRFRVSVCDTTEIPLKYS-------PMSIVL------GTVGG 498
            |||||..|..::.|.:::..|....|..|:||||.|       ...:||      |||.|
Human   443 IGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDGTVSG 502

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cyp6a2NP_523628.1 p450 36..502 CDD:278495 158/484 (33%)
CYP3A4NP_059488.2 p450 39..493 CDD:365848 155/477 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D264519at33208
OrthoFinder 1 1.000 - - FOG0000037
OrthoInspector 1 1.000 - - mtm8447
orthoMCL 1 0.900 - - OOG6_100014
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X40
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.820

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