Protein Alignment Cyp6a2 and CYP3A4

DIOPT Version :10

• Sequence 1: NP_523628.1
• Gene: Cyp6a2 / 35587
• FlyBaseID: FBgn0000473
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Alignment Length: 515
• Identity: 167/515 - (32%)
• Similarity: 266/515 - (51%)
• Gaps: 48/515 - (9%)

  Fly     6 YLLIAISSLLAYLY-HRNFNYWNRRGVPHDAPHPLYGNMVGFRKNRVMHDFFYDYYNKYRKSGFP 69
            :||:|:|.:|.||| ..:...:.:.|:|...|.|..||::.:.|...|.|.  :.:.||.|
Human    12 WLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDM--ECHKKYGK---- 70

  Fly    70 FVGFYFLHKPAAFIVDTQLAKNILIKD-FSNFADRGQFHNGRDDPLTQHLFNLDGKKWKDMRQRL 133
            ..|||...:|...|.|..:.|.:|:|: :|.|.:|..|  |....:...:...:.::||.:|..|
Human    71 VWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPF--GPVGFMKSAISIAEDEEWKRLRSLL 133

  Fly   134 TPTFTSGKMKFMFPTVIKVSEEFVKVITEQVPAAQNGAVLEIKELMARFTTDVIGTCAFGIECNT 198
            :|||||||:|.|.|.:.:..:..|:.:..:   |:.|..:.:|::...::.|||.:.:||:..::
Human   134 SPTFTSGKLKEMVPIIAQYGDVLVRNLRRE---AETGKPVTLKDVFGAYSMDVITSTSFGVNIDS 195

  Fly   199 LRTPVSDFRTMGQKVFTDMRHGKL------LTMFVFSFPKLASRLRMRMMPEDVHQFFMRLVNDT 257
            |..|...|....:|:   :|...|      :|:|.|..| :...|.:.:.|.:|..|..:.|...
Human   196 LNNPQDPFVENTKKL---LRFDFLDPFFLSITVFPFLIP-ILEVLNICVFPREVTNFLRKSVKRM 256

  Fly   258 IALRERENFK-RNDFMNLLIELKQKGRVTLDNGEVIEGMDIGELAAQVFVFYVAGFETSSSTMSY 321
            ...|..:..| |.||:.|:|: .|..:.|    |..:.:...||.||..:|..||:||:||.:|:
Human   257 KESRLEDTQKHRVDFLQLMID-SQNSKET----ESHKALSDLELVAQSIIFIFAGYETTSSVLSF 316

  Fly   322 CLYELAQNQDIQDRLRNEIQTVLEEQEGQLTYESIKAMTYLNQVISETLRLYTLVPHLERKALND 386
            .:||||.:.|:|.:|:.||..|| ..:...||:::..|.||:.|::|||||:.:...|||....|
Human   317 IMYELATHPDVQQKLQEEIDAVL-PNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKD 380

  Fly   387 YVVPGHEKLVIEKGTQVIIPACAYHRDEDLYPNPETFDPERFSPEKVAARESVEWLPFGDGPRNC 451
            ..:.|   :.|.||..|:||:.|.|||...:..||.|.|||||.:.....:...:.|||.|||||
Human   381 VEING---MFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNC 442

  Fly   452 IGMRFGQMQARIGLAQIISRFRVSVCDTTEIPLKYSPMSIVLGTVGG-------IYLRVE 504
            |||||..|..::.|.:::..|....|..|:||||.|        :||       :.|:||
Human   443 IGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLS--------LGGLLQPEKPVVLKVE 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	CYP6-like	69..500	CDD:410679	144/445 (32%)
CYP3A4	NP_059488.2	CYP3A	67..492	CDD:410743	147/454 (32%)