Protein Alignment Cyp6a2 and CYP2J2

DIOPT Version :10

• Sequence 1: NP_523628.1
• Gene: Cyp6a2 / 35587
• FlyBaseID: FBgn0000473
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_000766.2
• Gene: CYP2J2 / 1573
• HGNCID: 2634
• Length: 502
• Species: Homo sapiens
• Alignment Length: 542
• Identity: 118/542 - (21%)
• Similarity: 216/542 - (39%)
• Gaps: 107/542 - (19%)

  Fly     7 LLIAISSLLAYLYHRNFNYWNRRGVPHDAPHPLYGNMVGFRKNRVMHDFFYDYYNKYRKSGF--- 68
            :|.|:.||.|.|:          .|.|  |..|....|.|.       ...|:..:.|...:
Human     1 MLAAMGSLAAALW----------AVVH--PRTLLLGTVAFL-------LAADFLKRRRPKNYPPG 46

  Fly    69 ----PFVGFYFL------HK--------------------PAAFIVDTQLAKNILIKDFSNFADR 103
                ||:|.:||      |.                    .|..|....|.|..||....||.:|
Human    47 PWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEALIHMDQNFGNR 111

  Fly   104 GQFHNGRDDPLTQHLFNLD------GKKWKDMRQRLTPT----FTSGKMKFMFPTVIKVSEEFVK 158
            ..      .|:.:|:|..:      |:.||:.| |.|.|    |..|| |.:...:.:.::...:
Human   112 PV------TPMREHIFKKNGLIMSSGQAWKEQR-RFTLTALRNFGLGK-KSLEERIQEEAQHLTE 168

  Fly   159 VITEQVPAAQNGAVLEIKELMARFTTDVIGTCAFGIECNTLRTPVSDFRTMGQKVFTDMRHGKLL 223
            .|.|     :||...:....:....:::|.:..||.......:.......:..:| |.:...|..
Human   169 AIKE-----ENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEV-TYLEASKTC 227

  Fly   224 TMFVFSFPKLASRLRMRMMPEDVHQFF-----MRLVNDTIALRERENF---KRNDFMNLLIELKQ 280
            .::.. ||.:     |:.:|......|     ::|....:..:.|:::   :..||::..  ||:
Human   228 QLYNV-FPWI-----MKFLPGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETRDFIDAY--LKE 284

  Fly   281 KGRVTLDNGEVIEGMDIGELAAQVFVFYVAGFETSSSTMSYCLYELAQNQDIQDRLRNEIQTVLE 345
            ..:.|   |..........|.......:.||.||:|:|:.:.|..:|...:||::::.||..|:.
Human   285 MSKHT---GNPTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIG 346

  Fly   346 EQEGQLTYESIKAMTYLNQVISETLRLYTLVP-HLERKALNDYVVPGHEKLVIEKGTQVIIPACA 409
            :.: |.:..:.::|.|.|.||.|..|:..::| ::.|:...|..:.|:.   :.|||.::....|
Human   347 QGQ-QPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYH---LPKGTMILTNLTA 407

  Fly   410 YHRDEDLYPNPETFDPERFSPEKVAARESVEWLPFGDGPRNCIGMRFGQMQARIGLAQIISRFRV 474
            .|||...:..|:||:|:.|. |....::...::||..|.|.|:|.:..:.:..|....::.:|..
Human   408 LHRDPTEWATPDTFNPDHFL-ENGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTF 471

  Fly   475 SVCDTTEIPLKY------SPMS 490
            ...:..::.||:      ||:|
Human   472 RPPNNEKLSLKFRMGITISPVS 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	CYP6-like	69..500	CDD:410679	104/473 (22%)
CYP2J2	NP_000766.2	CYP2J	75..496	CDD:410755	98/449 (22%)