DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a2 and CYP3A7

DIOPT Version :9

Sequence 1:	NP_523628.1	Gene:	Cyp6a2 / 35587	FlyBaseID:	FBgn0000473	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_000756.3	Gene:	CYP3A7 / 1551	HGNCID:	2640	Length:	503	Species:	Homo sapiens

Alignment Length:	507	Identity:	164/507 - (32%)
Similarity:	261/507 - (51%)	Gaps:	32/507 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 YLLIAISSLLAYLY-HRNFNYWNRRGVPHDAPHPLYGNMVGFRKNRVMHDFFYDYYNKYRKSGFP 69
            :||:|:|.:|.||| .|....:.:.|:|...|.|..||.:.|||.....|.  :.|.||||
Human    12 WLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTFDM--ECYKKYRK---- 70

  Fly    70 FVGFYFLHKPAAFIVDTQLAKNILIKD-FSNFADRGQFHNGRDDPLTQHLFNLDGKKWKDMRQRL 133
            ..|.|...:|...|.|..:.|.:|:|: :|.|.:|..|  |....:...:...:.::||.:|..|
Human    71 VWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPF--GPVGFMKNAISIAEDEEWKRIRSLL 133

  Fly   134 TPTFTSGKMKFMFPTVIKVSEEFVKVITEQVPAAQNGAVLEIKELMARFTTDVIGTCAFGIECNT 198
            :|||||||:|.|.|.:.:..:..|:.:..:   |:.|..:.:|.:...::.|||.:.:||:..::
Human   134 SPTFTSGKLKEMVPIIAQYGDVLVRNLRRE---AETGKPVTLKHVFGAYSMDVITSTSFGVSIDS 195

  Fly   199 LRTPVSDFRTMGQKVFTDMRHGKL----LTMFVFSF-PKLASRLRMRMMPEDVHQFFMRLVNDTI 258
            |..|...|....:|:   :|...|    |::.||.| ..:...|.:.:.|..|..|..:.|....
Human   196 LNNPQDPFVENTKKL---LRFNPLDPFVLSIKVFPFLTPILEALNITVFPRKVISFLTKSVKQIK 257

  Fly   259 ALRERENFK-RNDFMNLLIELKQKGRVTLDNGEVIEGMDIGELAAQVFVFYVAGFETSSSTMSYC 322
            ..|.:|..| |.||:.|:|:.:..     .:.|..:.:...||.||..:|..||:||:||.:|:.
Human   258 EGRLKETQKHRVDFLQLMIDSQNS-----KDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFI 317

  Fly   323 LYELAQNQDIQDRLRNEIQTVLEEQEGQLTYESIKAMTYLNQVISETLRLYTLVPHLERKALNDY 387
            :||||.:.|:|.:::.||.||| ..:...||:::..:.||:.|::|||||:.:...|||....|.
Human   318 IYELATHPDVQQKVQKEIDTVL-PNKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDV 381

  Fly   388 VVPGHEKLVIEKGTQVIIPACAYHRDEDLYPNPETFDPERFSPEKVAARESVEWLPFGDGPRNCI 452
            .:.|   :.|.||..|:||:...|.|...:..||.|.|||||.:.....:...:.|||.||||||
Human   382 EING---MFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCI 443

  Fly   453 GMRFGQMQARIGLAQIISRFRVSVCDTTEIPLKYSPMSIVLGTVGGIYLRVE 504
            ||||..:..::.|.:::..|....|..|:||||.....::| |...|.|:.|
Human   444 GMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLL-TEKPIVLKAE 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	p450	36..502	CDD:278495	151/472 (32%)
CYP3A7	NP_000756.3	p450	39..492	CDD:365848	152/476 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.820