Protein Alignment Cyp6a2 and Cyp4b1

DIOPT Version :10

• Sequence 1: NP_523628.1
• Gene: Cyp6a2 / 35587
• FlyBaseID: FBgn0000473
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_031849.1
• Gene: Cyp4b1 / 13120
• MGIID: 103225
• Length: 511
• Species: Mus musculus
• Alignment Length: 535
• Identity: 125/535 - (23%)
• Similarity: 222/535 - (41%)
• Gaps: 90/535 - (16%)

  Fly     4 LIYLLIAISSLLAYLYHRNFNYWNRRGVPHDAPHPLYGNMVGFRKNRVMHDFFYDYYNKYRKSG- 67
            ::.|::.:..||:.|:.|..........|....|.|:|:.:                 :.:|:|
Mouse    19 VVILMVTVLKLLSLLFRRQKLARALDSFPGPPKHWLFGHAL-----------------EIQKTGG 66

  Fly    68 ----------FPFVGFYFLHKPAAFIVDTQLAKNILIKDFSNFADRGQFHNGRDDPLTQHLFN-- 120
                      ||:....:|.:...|:       ||...|::...      ..|.||...::::
Mouse    67 LDKVVTWTEQFPYAHPLWLGQFIVFL-------NIYEPDYAKAV------YSRGDPKAAYVYDFF 118

  Fly   121 ----------LDGKKWKDMRQRLTPTFTSGKMKFMFPTVIKVSEEFVKVITEQVPAAQNGAVLEI 175
                      |:|.||...|:.|||.|....:|   |.|...:|....::.:....|......:|
Mouse   119 LQWIGKGLLVLEGPKWFQHRKLLTPGFHYDVLK---PYVAIFAESTRVMLDKWEKKASENKSFDI 180

  Fly   176 KELMARFTTDVIGTCAFG-------IECNTLRTPVSDFR-TMGQKVFTDMRHGKLLTMFVFSFPK 232
            ...:.....|.:..|.||       ...|:....|||.. .|.|::.:...|..    |::....
Mouse   181 FCDVGHMALDTLMKCTFGKGDSGLSHSDNSYYLAVSDLTLLMQQRIDSFQYHND----FIYWLTP 241

  Fly   233 LASR-LRMRMMPEDVHQFFMR----LVNDTIALRERENFKRNDFMNLLIELKQKGRVTLDNGEVI 292
            ...| ||...:..|.....:|    .:.|....::.:..:..||:::|:..:.:..:.|.:
Mouse   242 HGRRFLRACQIAHDHTDHVIRQRKAALQDEKEQKKLQERRHLDFLDILLGARDESGIKLSD---- 302

  Fly   293 EGMDIGELAAQVFVFYVAGFETSSSTMSYCLYELAQNQDIQDRLRNEIQTVLEEQEGQLTYESIK 357
                 .:|.|:|..|...|.:|::|.:|:.||.:|.....|.|.|.|::.:|.::: ...::.:.
Mouse   303 -----ADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPMHQQRCREEVREILGDRD-SFQWDDLA 361

  Fly   358 AMTYLNQVISETLRLYTLVPHLERKALNDYV-VPGHEKLVIEKGTQVIIPACAYHRDEDLYPNPE 421
            .||||...:.|..|||..||.:.|:...... |.|..   :..|:.:.:...|.||:..::|:||
Mouse   362 QMTYLTMCMKECFRLYPPVPQVYRQLSKPVTFVDGRS---LPAGSLISLHIYALHRNSAVWPDPE 423

  Fly   422 TFDPERFSPEKVAARESVEWLPFGDGPRNCIGMRFGQMQARIGLAQIISRFRVSVCDTTEIPLKY 486
            .|||.|||||.:..|....::||..|||||||.:|...:.::..|..:.||..|. |.::||:|.
Mouse   424 VFDPLRFSPENMTGRHPFAFMPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEFSP-DPSKIPIKV 487

  Fly   487 SPMSIVLGTVGGIYL 501
            .  .::|.:..||:|
Mouse   488 P--QLILRSKNGIHL 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	CYP6-like	69..500	CDD:410679	111/456 (24%)
Cyp4b1	NP_031849.1	CYP4B-like	67..501	CDD:410771	114/470 (24%)