Protein Alignment Cyp6a2 and Cyp46a1

DIOPT Version :10

• Sequence 1: NP_523628.1
• Gene: Cyp6a2 / 35587
• FlyBaseID: FBgn0000473
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_034140.1
• Gene: Cyp46a1 / 13116
• MGIID: 1341877
• Length: 500
• Species: Mus musculus
• Alignment Length: 500
• Identity: 123/500 - (24%)
• Similarity: 221/500 - (44%)
• Gaps: 81/500 - (16%)

  Fly     7 LLIAISSLLAYLYHRNFNYWNRRGVPHDAPHPLYGNMVGFRK-----NRVMHDFFYDYYNKYRKS 66
            :|:|......:::.....|.:..|.|.  |..|.|::..|.|     .||:.|.|.|:..||.
Mouse    12 VLLAFGLCCTFVHRARSRYEHIPGPPR--PSFLLGHLPYFWKKDEDCGRVLQDVFLDWAKKYG-- 72

  Fly    67 GFPFVGFYFLHKPAAFIVDTQLAKNILIKDFSNFADRGQFHNGRDDPLTQHLF------NLDGKK 125
              |.|.....:|.:..:...:..|..|:.  :.:....:.:........:.||      ..|..:
Mouse    73 --PVVRVNVFYKTSVIVTSPESVKKFLMS--TKYNKDSKMYRALQTVFGERLFGQGLVSECDYGR 133

  Fly   126 WKDMRQRLTPTFTSGKMKFMFPTVIKVSEEFVKVITEQVPAAQNGAVLEIKELMARFTTDVIGTC 190
            |...|:.:...|:...:..:..|..:.:|:.|:::..:   |.....:.:::::...|.|::...
Mouse   134 WYKQRKVMDLAFSRSSLVSLMETFNEKAEQLVEILEAK---ADGQTPVSMQDMLTCATIDILAKA 195

  Fly   191 AFGIECNTL---RTPVSDFRTMGQKVFTDMRHGKLLTMFVFSFPKLASRLRMRMMPEDVHQFFMR 252
            |||:|.:.|   :.|:|    ...||..:.......|:..|...|   |.::|.:.|.:.  .:|
Mouse   196 AFGMETSMLLGAQKPLS----QAVKVMLEGISASRNTLAKFMPGK---RKQLREIRESIR--LLR 251

  Fly   253 LVNDTIALRERENFKRNDFM--NLLIEL------KQKGRVTLDNGEVIEGMDIGELAAQVFV-FY 308
            .|......|.||..||.:.|  ::|.::      .|...|.|||                || |:
Mouse   252 QVGKDWVQRRREALKRGEDMPADILTQILKAEEGAQDDEVLLDN----------------FVTFF 300

  Fly   309 VAGFETSSSTMSYCLYELAQNQDIQDRLRNEIQTVLEEQEGQLTYESIKAMTYLNQVISETLRLY 373
            :||.|||::.:::.:.||::..:|..||:.|:..|:..:. .|.||.:..:.||:||:.|:||||
Mouse   301 IAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVVGSKR-HLDYEDLGRLQYLSQVLKESLRLY 364

  Fly   374 TLVPH------LERKALNDYV-VPGHEKLVIEKGTQVIIPACAYHRDEDLYPNPETFDPERFSPE 431
            .  |.      ||.:.|.|.| |||:        |.::.......|.:..:.:|.||:|:||.|.
Mouse   365 P--PAWGTFRLLEEETLIDGVRVPGN--------TPLLFSTYVMGRMDTYFEDPLTFNPDRFGPG 419

  Fly   432 KVAARESVEWLPFGDGPRNCIGMRFGQMQARIGLAQIISR--FRV 474
              |.:....:.||..|.|:|||.:|.||:.::.:|:::.|  ||:
Mouse   420 --APKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRIEFRL 462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	CYP6-like	69..500	CDD:410679	106/432 (25%)
Cyp46a1	NP_034140.1	CYP46A1-like	61..484	CDD:410706	111/448 (25%)