DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a2 and Cyp3a13

DIOPT Version :9

Sequence 1:	NP_523628.1	Gene:	Cyp6a2 / 35587	FlyBaseID:	FBgn0000473	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_031845.1	Gene:	Cyp3a13 / 13113	MGIID:	88610	Length:	503	Species:	Mus musculus

Alignment Length:	496	Identity:	160/496 - (32%)
Similarity:	260/496 - (52%)	Gaps:	33/496 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 YLLIAISSLLAYLY-HRNFNYWNRRGVPHDAPHPLYGNMVGFRKNRVMHDFFYD----YYNKYRK 65
            ::|:|.|.:|.||| ..:...:.:.|:|...|.|..|.::.::|.      |::    .:.||.|
Mouse    12 WMLLATSLVLLYLYGTHSHGIFKKLGIPGPKPLPFLGTILAYQKG------FWECDIQCHKKYGK 70

  Fly    66 SGFPFVGFYFLHKPAAFIVDTQLAKNILIKD-FSNFADRGQFHNGRDDPLTQHLFNLDGKKWKDM 129
                ..|.|...:|...|.|..:.|.:|:|: :|.|.:|.:|  |....|.:.:...:.::||.:
Mouse    71 ----MWGLYDGRQPVLAITDPDIIKTVLVKECYSTFTNRRRF--GPVGILKKAISISENEEWKRI 129

  Fly   130 RQRLTPTFTSGKMKFMFPTVIKVSEEFVKVITEQVPAAQNGAVLEIKELMARFTTDVIGTCAFGI 194
            |..|:||||||::|.|||.:.:.::..|:.:.:   ....|....:|::...::.|||...:||:
Mouse   130 RALLSPTFTSGRLKEMFPIINQFTDVLVRNMRQ---GLGEGKPTSMKDIFGAYSMDVITATSFGV 191

  Fly   195 ECNTLRTPVSDFRTMGQKVFT-DMRHGKLLTMFVFSF-PKLASRLRMRMMPEDVHQFFMRLVNDT 257
            ..::|..|...|....:|:.. |:.....|::.:|.| ..:...|.:.:.|.||..||...|...
Mouse   192 NIDSLNNPQDPFVEKIKKLLKFDIFDPLFLSVTLFPFLTPVFDALNVSLFPRDVISFFTTSVERM 256

  Fly   258 IALRERENFK-RNDFMNLLIELKQKGRVTLDNGEVIEGMDIGELAAQVFVFYVAGFETSSSTMSY 321
            ...|.:|..| |.||:.|:|  ..:...|.::.:.:..:   |:.||..:|..||:||:||.:|:
Mouse   257 KENRMKEKEKQRVDFLQLMI--NSQNYKTKESHKALSDV---EIVAQSVIFIFAGYETTSSALSF 316

  Fly   322 CLYELAQNQDIQDRLRNEIQTVLEEQEGQLTYESIKAMTYLNQVISETLRLYTLVPHLERKALND 386
            .||.||.:.|:|.:|::||...| ..:...||:::..|.||:.|::||||||.:...|||....|
Mouse   317 ALYLLAIHPDVQKKLQDEIDAAL-PNKAPATYDTLLQMEYLDMVVNETLRLYPIAGRLERVCKTD 380

  Fly   387 YVVPGHEKLVIEKGTQVIIPACAYHRDEDLYPNPETFDPERFSPEKVAARESVEWLPFGDGPRNC 451
            ..:.|   |.|.|||.|:||..|.|:|...:|.||.|.|||||.:...:.....:||||.|||||
Mouse   381 VEING---LFIPKGTVVMIPTFALHKDPKYWPEPEEFRPERFSKKNQDSINPYMYLPFGSGPRNC 442

  Fly   452 IGMRFGQMQARIGLAQIISRFRVSVCDTTEIPLKYSPMSIV 492
            |||||..:..::.|.:::..|.|..|..||||||.|...::
Mouse   443 IGMRFALINMKVALVRVLQNFTVQPCKETEIPLKLSKQGLL 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	p450	36..502	CDD:278495	151/465 (32%)
Cyp3a13	NP_031845.1	p450	39..491	CDD:365848	152/469 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.710