DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a2 and Cyp3a11

DIOPT Version :9

Sequence 1:	NP_523628.1	Gene:	Cyp6a2 / 35587	FlyBaseID:	FBgn0000473	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_031844.1	Gene:	Cyp3a11 / 13112	MGIID:	88609	Length:	504	Species:	Mus musculus

Alignment Length:	492	Identity:	160/492 - (32%)
Similarity:	264/492 - (53%)	Gaps:	24/492 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 YLLIAISSLLAYLY-HRNFNYWNRRGVPHDAPHPLYGNMVGFRKNRVMHDFFYDYYNKYRKSGFP 69
            ::|:|||.:|.|.| .|....:.::|:|...|.|..|.::.:.|.  :..|..:.|.||.|:...
Mouse    12 WVLLAISLVLLYRYGTRKHELFKKQGIPGPKPLPFLGTVLNYYKG--LWKFDMECYKKYGKTWGL 74

  Fly    70 FVGFYFLHKPAAFIVDTQLAKNILIKD-FSNFADRGQFHNGRDDPLTQHLFNLDGKKWKDMRQRL 133
            |.|    ..|...:.|.:..||:|:|: ||.|.:|..|  |....:::.:......:||..|..|
Mouse    75 FDG----QTPLLAVTDPETIKNVLVKECFSVFTNRRDF--GPVGIMSKAISISKDDEWKRYRALL 133

  Fly   134 TPTFTSGKMKFMFPTVIKVSEEFVKVITEQVPAAQNGAVLEIKELMARFTTDVIGTCAFGIECNT 198
            :|||||||:|.|||.:.:..:..||.:.::   |:.|..:.:|:::..::.|||.:.:||:..::
Mouse   134 SPTFTSGKLKEMFPVIEQYGDILVKYLRQK---AKKGKPVTMKDVLGAYSMDVITSTSFGVNVDS 195

  Fly   199 LRTPVSDFRTMGQKVFT-DMRHGKLLTMFVFSF-PKLASRLRMRMMPEDVHQFFMRLVNDTIALR 261
            |..|...|....:|:.. |.....|.::.:|.| ..:...|.:.|.|:|..:||.:.|:.....|
Mouse   196 LNNPEDPFVEKAKKLLRFDFFDPLLFSVVLFPFLTPVYEMLNICMFPKDSIEFFKKFVDRMKESR 260

  Fly   262 -ERENFKRNDFMNLLIELKQKGRVTLDNGEVIEGMDIGELAAQVFVFYVAGFETSSSTMSYCLYE 325
             :.:...|.||:.|::......:..:.: :.:..|   |:.||..:|..||:||:|||:|:.|:.
Mouse   261 LDSKQKHRVDFLQLMMNSHNNSKDKVSH-KALSDM---EITAQSIIFIFAGYETTSSTLSFTLHS 321

  Fly   326 LAQNQDIQDRLRNEIQTVLEEQEGQLTYESIKAMTYLNQVISETLRLYTLVPHLERKALNDYVVP 390
            ||.:.|||.:|::||...| ..:...||:::..|.||:.|::||||||.:...|||....|..:.
Mouse   322 LATHPDIQKKLQDEIDEAL-PNKAPPTYDTVMEMEYLDMVLNETLRLYPIANRLERVCKKDVELN 385

  Fly   391 GHEKLVIEKGTQVIIPACAYHRDEDLYPNPETFDPERFSPEKVAARESVEWLPFGDGPRNCIGMR 455
            |   :.|.||:.|:||:.|.|.|...:..||.|.|||||.|...:.:...:||||:|||||:|||
Mouse   386 G---VYIPKGSTVMIPSYALHHDPQHWSEPEEFQPERFSKENKGSIDPYVYLPFGNGPRNCLGMR 447

  Fly   456 FGQMQARIGLAQIISRFRVSVCDTTEIPLKYSPMSIV 492
            |..|..::.|.:|:..|....|..|:||||.|...::
Mouse   448 FALMNMKLALTKIMQNFSFQPCKETQIPLKLSRQGLL 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	p450	36..502	CDD:278495	150/461 (33%)
Cyp3a11	NP_031844.1	p450	39..494	CDD:278495	151/465 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.720