Protein Alignment Cyp6a2 and CYP4F22

DIOPT Version :10

• Sequence 1: NP_523628.1
• Gene: Cyp6a2 / 35587
• FlyBaseID: FBgn0000473
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_775754.2
• Gene: CYP4F22 / 126410
• HGNCID: 26820
• Length: 531
• Species: Homo sapiens
• Alignment Length: 402
• Identity: 104/402 - (25%)
• Similarity: 188/402 - (46%)
• Gaps: 45/402 - (11%)

  Fly   123 GKKWKDMRQRLTPTFTSGKMKFMFPTVIKVSEEFVKVITEQVP--------AAQNGAV-LEIKEL 178
            |.||...|:.|||.|.           ..:.:.::|:..:...        .|:..|| |::.|.
Human   149 GDKWSRHRRLLTPAFH-----------FDILKPYMKIFNQSADIMHAKWRHLAEGSAVSLDMFEH 202

  Fly   179 MARFTTDVIGTCAFGIECNTLRTPVSDF--RTMGQKVFTDMRHGKLLTMFVFSFPKLASRLRMRM 241
            ::..|.|.:..|.|....| .:..:||:  ..:.....:..|..:|.....|.:.:.|...|.|.
Human   203 ISLMTLDSLQKCVFSYNSN-CQEKMSDYISAIIELSALSVRRQYRLHHYLDFIYYRSADGRRFRQ 266

  Fly   242 MPEDVHQFFMRLVNDTIALRERENFKRNDFMNLLIELKQKGRVTLDNGEVI------EGMDIG-- 298
            ..:.||.|      .|..::||....|.......::.|| |: |||..:|:      :|.::.
Human   267 ACDMVHHF------TTEVIQERRRALRQQGAEAWLKAKQ-GK-TLDFIDVLLLARDEDGKELSDE 323

  Fly   299 ELAAQVFVFYVAGFETSSSTMSYCLYELAQNQDIQDRLRNEIQTVLEEQE-GQLTYESIKAMTYL 362
            ::.|:...|...|.:|:||.:|:.|:.||:..:.|::.|.|||.|::.:| .:|.::.:..:.:.
Human   324 DIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLTQLPFT 388

  Fly   363 NQVISETLRLYTLVPHLERKALNDYVVPGHEKLVIEKGTQVIIPACAYHRDEDLYPNPETFDPER 427
            ...|.|:||.|..|..:.|:...|..:|  :..:|.||...::.....|.:..::|:.:.::|.|
Human   389 TMCIKESLRQYPPVTLVSRQCTEDIKLP--DGRIIPKGIICLVSIYGTHHNPTVWPDSKVYNPYR 451

  Fly   428 FSPEKVAARESVEWLPFGDGPRNCIGMRFGQMQARIGLAQIISRFRVSVCDTTEIPLKYSPMSIV 492
            |.|:....|..:.::||..|||||||..|...:.|:.:|..:.|||:||..|.::..|   ..::
Human   452 FDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRLSVDRTRKVRRK---PELI 513

  Fly   493 LGTVGGIYLRVE 504
            |.|..|::|:||
Human   514 LRTENGLWLKVE 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	CYP6-like	69..500	CDD:410679	101/396 (26%)
CYP4F22	NP_775754.2	CYP4F	82..523	CDD:410772	101/398 (25%)