Protein Alignment Cyp6a2 and CYP2R1

DIOPT Version :10

• Sequence 1: NP_523628.1
• Gene: Cyp6a2 / 35587
• FlyBaseID: FBgn0000473
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_078790.2
• Gene: CYP2R1 / 120227
• HGNCID: 20580
• Length: 501
• Species: Homo sapiens
• Alignment Length: 525
• Identity: 119/525 - (22%)
• Similarity: 208/525 - (39%)
• Gaps: 122/525 - (23%)

  Fly     1 MFVLIYLLIAISSLLAYLYHRNFNYWNRR--GVPHDAPH-PLYGNMVGFRKNRVMHDFFYDYYNK 62
            :|:|::.| .:..||.          .||  |.|...|. |..||:                |:.
Human    18 LFLLLFAL-GVRQLLK----------QRRPMGFPPGPPGLPFIGNI----------------YSL 55

  Fly    63 YRKSGFPFVGFYFLHKPA-----AFIVDT-----------QLAKNILIKDFSNFADR-------- 103
            ...|..|.|   ::.|.:     .|.:|.           .:.|..|:.....||||
Human    56 AASSELPHV---YMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMK 117

  Fly   104 ----GQFHNGRDDPLTQHLFNLDGKKWKDMRQRLTPTFT---SGKMKFMFPTVIKVSEEFVKVIT 161
                |...|.|           .|:.|.|.|:....:|.   .|:..|    ..|:.|| .|...
Human   118 MTKMGGLLNSR-----------YGRGWVDHRRLAVNSFRYFGYGQKSF----ESKILEE-TKFFN 166

  Fly   162 EQVPAAQNGAVLEIKELMARFTTDVIGTCAFGIECNTLRTPVSDFRTMGQKVFTDMRHGKLLTMF 226
            :.: ....|...:.|:|:....:::.....|| |..|...  :||:.|.:....::......::|
Human   167 DAI-ETYKGRPFDFKQLITNAVSNITNLIIFG-ERFTYED--TDFQHMIELFSENVELAASASVF 227

  Fly   227 VF-SFPKLASRLRMRMMPEDVHQFFMR---LVNDTIA-LRERENFKR-----NDFMNLLIELKQK 281
            :: :||.:.      ::|...||...|   :|.|.:: |.|:.:..|     ..|::..::...:
Human   228 LYNAFPWIG------ILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQ 286

  Fly   282 GR----VTLDNGEVIEGMDIGELAAQVFVFYVAGFETSSSTMSYCLYELAQNQDIQDRLRNEIQT 342
            |:    .|.....:|  ..:|||       .:||.||:::.:.:.:..:|...:||.:::.||..
Human   287 GKNDPSSTFSKENLI--FSVGEL-------IIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDL 342

  Fly   343 VLEEQEGQLTYESIKAMTYLNQVISETLRLYTLVP-HLERKALNDYVVPGHEKLVIEKGTQVIIP 406
            :: ...|:.:::....|.|...|:.|.||...:|| .:......|.||.|:.   |.|||.||..
Human   343 IM-GPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYS---IPKGTTVITN 403

  Fly   407 ACAYHRDEDLYPNPETFDPERF--SPEKVAARESVEWLPFGDGPRNCIGMRFGQMQARIGLAQII 469
            ..:.|.||..:.:||.|.||||  |....|.:|::  :||..|.|:|:|....:|:..:....::
Human   404 LYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEAL--VPFSLGRRHCLGEHLARMEMFLFFTALL 466

  Fly   470 SRFRV 474
            .||.:
Human   467 QRFHL 471

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	CYP6-like	69..500	CDD:410679	104/454 (23%)
CYP2R1	NP_078790.2	CYP2R1	62..497	CDD:410754	104/454 (23%)