DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a2 and Cyp4f15

DIOPT Version :9

Sequence 1:	NP_523628.1	Gene:	Cyp6a2 / 35587	FlyBaseID:	FBgn0000473	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_598888.1	Gene:	Cyp4f15 / 106648	MGIID:	2146921	Length:	534	Species:	Mus musculus

Alignment Length:	554	Identity:	138/554 - (24%)
Similarity:	231/554 - (41%)	Gaps:	102/554 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LIYLLIAISSLLA------YLYHRNFNY---------WN----RRGVPHDAPHPL--YGNMVGFR 47
            |:.|||..|.|||      |:::|.:::         ||    ..|:.....|.|  ..|:|.
Mouse    25 LLLLLIGASWLLARVLTQTYIFYRTYHHLCDFPQPPKWNWFLGHLGMITPTEHGLKEVTNLVA-- 87

  Fly    48 KNRVMHDFFYDYYNKYRKSGFPFVGFYFLHKPAAFIVDTQLAKNILIKDFSNFADRGQFHNGRDD 112
                          .|.:....::|...   |...:....:.:::|....|.......|::....
Mouse    88 --------------TYPQGFMTWLGPII---PIITLCHPDIIRSVLNASASVALKEVVFYSFLKP 135

  Fly   113 PLTQHLFNLDGKKWKDMRQRLTPTFTSGKMKFMFPTVIKVSEEFVKVITE---------QVPAAQ 168
            .|...|...||.||...|:.|||.|.           ..:.:.:||:..:         |..|:.
Mouse   136 WLGDGLLLSDGDKWSSHRRMLTPAFH-----------FNILKPYVKIFNDSTNIMHAKWQHLASG 189

  Fly   169 NGAVLEIKELMARFTTDVIGTCAFGIECNTLRTPVSDF--RTMGQKVFTDMRHGKLLTMFVFSFP 231
            ..|.|::.|.::..|.|.:..|.|..:.|....| |::  ..:........|:.:||......:.
Mouse   190 GSARLDVFENISLMTLDSLQKCVFSFDSNCQENP-SEYISAILELSALVTKRYHQLLLHIDSLYQ 253

  Fly   232 KLASRLRMRMMPEDVHQFFMRLVND---TI-------ALRERENFKRNDFMNLLIELKQKGRVTL 286
            ...|..|.......||.|...::.|   |:       .|:.:...|..||:::|:..|.
Mouse   254 LTCSGRRFHKACHLVHSFTDAVIQDRRRTLPSKHEDDVLKAKAKSKTLDFIDVLLLSKD------ 312

  Fly   287 DNGEVIEGMDIGELAAQVFVFYVAGFETSSSTMSYCLYELAQNQDIQDRLRNEIQTVLEEQEGQ- 350
            ::|:.:...||   .|:...|...|.:|::|.:|:.||.||::.:.|:|.|.|:|.:|.::|..
Mouse   313 EDGKELSDEDI---RAEADTFMFEGHDTTASGLSWILYNLARHPEYQERCRQEVQELLRDRESTE 374

  Fly   351 -------LTYESIKAMTYLNQVISETLRLYTLVPHLERKALNDYVVPGHEKLVIEKGTQVIIPAC 408
                   ...:.:..:.:|...|.|:|||:..|..:.|:...|.|:|  :..||.||...||...
Mouse   375 IECSCAVFLRDDLAQLPFLTMCIKESLRLHPPVTVISRRCTQDIVLP--DGRVIPKGVICIINIF 437

  Fly   409 AYHRDEDLYPNPETFDPERFSPEKVAARESVEWLPFGDGPRNCIGMRFGQMQARIGLAQIISRFR 473
            |.|.:..::|:||.:||.||.||.:..|..:.::||..|||||||..|...:.::.||..:.|||
Mouse   438 ATHHNPTVWPDPEVYDPFRFDPENIKDRSPLAFIPFSAGPRNCIGQTFAMNEMKVALALTLLRFR 502

  Fly   474 VSVCDTTEIPLKYSPM---SIVLGTVGGIYLRVE 504
            |       :|....|.   .::|...||::||||
Mouse   503 V-------LPDDKEPRRKPELILRAEGGLWLRVE 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	p450	36..502	CDD:278495	121/499 (24%)
Cyp4f15	NP_598888.1	p450	57..526	CDD:278495	124/517 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900