DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a2 and Cyp4v3

DIOPT Version :9

Sequence 1:	NP_523628.1	Gene:	Cyp6a2 / 35587	FlyBaseID:	FBgn0000473	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_598730.1	Gene:	Cyp4v3 / 102294	MGIID:	2142763	Length:	525	Species:	Mus musculus

Alignment Length:	565	Identity:	146/565 - (25%)
Similarity:	224/565 - (39%)	Gaps:	140/565 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLIAISSLLAYLYHRNFNYWNR-RGVPHDA-PHPLYGNMVGFRKNRVMHDFFYD---YYNKYRK- 65
            :||:|..:|. .|.|.   |.: |.:|..| .:||.|:.:..:.|..  :||..   |..::|.
Mouse    29 ILISIFPMLV-SYARK---WQQMRSIPSVARAYPLVGHALYMKPNNA--EFFQQLIYYTEEFRHL 87

  Fly    66 -------SGFPFVGFYFLHKPAAFIVDT-QLAKNILIKDFSNFADRGQFHNGRDDPLTQHLFNLD 122
                   ...|.|..|........:..: |:.|:.|.|....:...|             |....
Mouse    88 PIIKLWIGPVPLVALYKAENVEVILTSSKQIDKSFLYKFLQPWLGLG-------------LLTST 139

  Fly   123 GKKWKDMRQRLTPTFTSGKMKFMFPTVIKVSEEFVKVITEQVPAAQNGAVLEIKELMARFTTDV- 186
            |.||:..|:.|||||.           ..:.|.|:.|:.||       |.:.:.:|......:.
Mouse   140 GSKWRTRRKMLTPTFH-----------FTILENFLDVMNEQ-------ANILVNKLEKHVNQEAF 186

  Fly   187 -----IGTCAFGIECNTLRTPVSDFRTMGQKVFTDMRHGKLLTMFVFSFPKLASRLRMRMMP--- 243
                 |..||..|.|.|         .||:.:.....:.......|:....:..| ||: ||
Mouse   187 NCFFYITLCALDIICET---------AMGKNIGAQSNNDSEYVRTVYRMSDMIYR-RMK-MPWLW 240

  Fly   244 ------------------EDVHQFFMRLVNDTIALRERE-----------------NFKRNDFMN 273
                              :.:|.|    .|:.||.|.:|                 ..||..|::
Mouse   241 FDLWYLVFKEGRDHKRGLKCLHTF----TNNVIAERVKERKAEEDWTGAGRGPIPSKNKRKAFLD 301

  Fly   274 LLIELKQKGRVTLDNGEVIEGMDIGELAAQVFVFYVAGFETSSSTMSYCLYELAQNQDIQDRLRN 338
            ||:.      ||.:.|..:...||.|   :|..|...|.:|:::.:::.||.|..|.::|.::..
Mouse   302 LLLS------VTDEEGNRLSQEDIRE---EVDTFMFEGHDTTAAAINWSLYLLGTNPEVQRKVDQ 357

  Fly   339 EIQTVLEEQEGQLTYESIKAMTYLNQVISETLRLYTLVPHLERKALNDYVVPGHEKLVIEKGTQV 403
            |:..|.......:|.|.:|.:.||:.||.||||::..||...|....|..|.|::   :.|||:.
Mouse   358 ELDEVFGRSHRPVTLEDLKKLKYLDCVIKETLRVFPSVPLFARSLSEDCEVGGYK---VTKGTEA 419

  Fly   404 IIPACAYHRDEDLYPNPETFDPERFSPEKVAARESVEWLPFGDGPRNCIGMRFGQMQARIGLAQI 468
            ||...|.|||...:|:||.|.||||.||....|....::||..|||||||.:|..|:.:..||.|
Mouse   420 IIIPYALHRDPRYFPDPEEFRPERFFPENSQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILACI 484

  Fly   469 ISRFRVSVCDTTEIPLKYSPMSIVLGTVG--------GIYLRVER 505
            :.:|.|......|          .||..|        ||:::::|
Mouse   485 LRQFWVESNQKRE----------ELGLAGDLILRPNNGIWIKLKR 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	p450	36..502	CDD:278495	135/529 (26%)
Cyp4v3	NP_598730.1	p450	51..517	CDD:278495	137/535 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810