Protein Alignment CG9436 and AKR1C3

DIOPT Version :10

• Sequence 1: NP_610235.1
• Gene: CG9436 / 35586
• FlyBaseID: FBgn0033101
• Length: 311
• Species: Drosophila melanogaster
• Sequence 2: NP_003730.4
• Gene: AKR1C3 / 8644
• HGNCID: 386
• Length: 323
• Species: Homo sapiens
• Alignment Length: 317
• Identity: 128/317 - (40%)
• Similarity: 180/317 - (56%)
• Gaps: 14/317 - (4%)

  Fly     8 IRLNNGREMPTLGLGTWKSFE---SDAYHSTRHALDVGYRHLDTAFVYENEAEVGQAISEKIAEG 69
            ::||:|..||.||.||:...|   |.|...|:.|::.|:||:|:|.:|.||.:||.||..|||:|
Human     8 VKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADG 72

  Fly    70 VVTREEVFVTTKLGGIHHDPALVERACRLSLSNLGLEYVDLYLMHMPVGQKFHND---SNVHGTL 131
            .|.||::|.|:||....|.|.||..|...||....|:||||||:|.|:..|...:   ::.:|.:
Human    73 SVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPGEELSPTDENGKV 137

  Fly   132 ELTDVDYLDTWREMEKLVDLGLTRSIGLSNFNAAQTERVL--ANCRIRPVVNQVECHPGFQQRQL 194
            ....||...||..|||..|.||.:|||:||||..|.|.:|  ...:.:||.|||||||.|.:.:|
Human   138 IFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNRSKL 202

  Fly   195 REHAKRHGLVICAYCPLARPQPARQW-----PPFLYDEHAQNLAKKYGRTTAQICLRYLVQLGVV 254
            .:..|...:|:.||..|. .|..::|     |..|.|.....||||:.||.|.|.|||.:|.|||
Human   203 LDFCKSKDIVLVAYSALG-SQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVV 266

  Fly   255 PLPKSSNKARIEENFRVFDFELSPDDVAGMEQYHTGQRTVPFSGMSGHKYYPFNDEF 311
            .|.||.|:.||.:|.:||:|:|:.:|:..::..............:.|..||::||:
Human   267 VLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNLHYFNSDSFASHPNYPYSDEY 323

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9436	NP_610235.1	AKR_AKR2E1-5	6..294	CDD:381342	123/298 (41%)
AKR1C3	NP_003730.4	AKR_AKR1C1-35	6..306	CDD:381334	123/298 (41%)