Protein Alignment CG9436 and AKR1C8

DIOPT Version :10

• Sequence 1: NP_610235.1
• Gene: CG9436 / 35586
• FlyBaseID: FBgn0033101
• Length: 311
• Species: Drosophila melanogaster
• Sequence 2: XP_047281112.1
• Gene: AKR1C8 / 340811
• HGNCID: 23469
• Length: 398
• Species: Homo sapiens
• Alignment Length: 348
• Identity: 133/348 - (38%)
• Similarity: 187/348 - (53%)
• Gaps: 64/348 - (18%)

  Fly     1 MTNL--APTIRLNNGREMPTLGLGTW---KSFESDAYHSTRHALDVGYRHLDTAFVYENEAEVGQ 60
            ||:|  :.::|||:|..||.||.||:   .:.:|.|..:|:.|:|||:||:|:|::|:||.||||
Human     2 MTDLKQSHSVRLNDGPFMPVLGFGTYAPDHTPKSQAAEATKVAIDVGFRHIDSAYLYQNEEEVGQ 66

  Fly    61 AISEKIAEGVVTREEVFVTTKLGGIHHDPALVERACRLSLSNLGLEYVDLYLMHMPVGQK----- 120
            ||.||||:|.|.|||:|.|.||........||..|...||..||.:||||:::|:|...|
Human    67 AIWEKIADGTVKREEIFYTIKLWATFFRAELVHPALERSLKKLGPDYVDLFIIHVPFAMKVSFCF 131

  Fly   121 -------FHND----------------------SNVH-----------------GTLELTDVDYL 139
                   ||:.                      |.||                 |.:.|..|:..
Human   132 SLLCPRLFHHGYKHLNYLILAWFPGFFLREADLSEVHRIAKTFPGKELLPKDASGEIILETVELC 196

  Fly   140 DTWREMEKLVDLGLTRSIGLSNFNAAQTERVL--ANCRIRPVVNQVECHPGFQQRQLREHAKRHG 202
            |||..:||..:.|||||||:||||....|.:|  ...:.:|..|||||||...|.:|.|..|...
Human   197 DTWEALEKCKEAGLTRSIGVSNFNHKLLELILNKPGLKYKPTCNQVECHPYLNQSKLLEFCKSKD 261

  Fly   203 LVICAYCPLARPQPARQW-----PPFLYDEHAQNLAKKYGRTTAQICLRYLVQLGVVPLPKSSNK 262
            :|:.||..|. .|...||     |..|.:...:::|||:..:..|:.|||.:|.|||.|.||.::
Human   262 IVLVAYSALG-SQRDPQWVDPDCPHLLEEPILKSIAKKHSGSPGQVALRYQLQRGVVVLAKSFSQ 325

  Fly   263 ARIEENFRVFDFELSPDDVAGME 285
            .||:|||::|||||:|:|:..::
Human   326 ERIKENFQIFDFELTPEDMKAID 348

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9436	NP_610235.1	AKR_AKR2E1-5	6..294	CDD:381342	130/341 (38%)
AKR1C8	XP_047281112.1	AKR_AKR1C1-35	9..356	CDD:381334	130/341 (38%)