Protein Alignment CG9436 and AKR1C2

DIOPT Version :10

• Sequence 1: NP_610235.1
• Gene: CG9436 / 35586
• FlyBaseID: FBgn0033101
• Length: 311
• Species: Drosophila melanogaster
• Sequence 2: NP_001345.1
• Gene: AKR1C2 / 1646
• HGNCID: 385
• Length: 323
• Species: Homo sapiens
• Alignment Length: 321
• Identity: 135/321 - (42%)
• Similarity: 182/321 - (56%)
• Gaps: 22/321 - (6%)

  Fly     8 IRLNNGREMPTLGLGTWKSFE---SDAYHSTRHALDVGYRHLDTAFVYENEAEVGQAISEKIAEG 69
            ::||:|..||.||.||:...|   |.|..:.:.|::.|:.|:|:|.||.||.:||.||..|||:|
Human     8 VKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADG 72

  Fly    70 VVTREEVFVTTKLGGIHHDPALVERACRLSLSNLGLEYVDLYLMHMPVGQK-----FHNDSNVHG 129
            .|.||::|.|:||....|.|.||..|...||.||.|:||||||:|.||..|     ...|.|  |
Human    73 SVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDEN--G 135

  Fly   130 TLELTDVDYLDTWREMEKLVDLGLTRSIGLSNFNAAQTERVL--ANCRIRPVVNQVECHPGFQQR 192
            .:....||...||..|||..|.||.:|||:||||....|.:|  ...:.:||.|||||||.|.||
Human   136 KILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLKYKPVCNQVECHPYFNQR 200

  Fly   193 QLREHAKRHGLVICAYCPLA--RPQPARQW-----PPFLYDEHAQNLAKKYGRTTAQICLRYLVQ 250
            :|.:..|...:|:.||..|.  |.:|   |     |..|.|.....||||:.||.|.|.|||.:|
Human   201 KLLDFCKSKDIVLVAYSALGSHREEP---WVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQ 262

  Fly   251 LGVVPLPKSSNKARIEENFRVFDFELSPDDVAGMEQYHTGQRTVPFSGMSGHKYYPFNDEF 311
            .|||.|.||.|:.||.:|.:||:|:|:.:::..::..:...|.:.....:|...|||:||:
Human   263 RGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTLDIFAGPPNYPFSDEY 323

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9436	NP_610235.1	AKR_AKR2E1-5	6..294	CDD:381342	129/302 (43%)
AKR1C2	NP_001345.1	AKR_AKR1C1-35	6..308	CDD:381334	129/304 (42%)