Protein Alignment CG9436 and AKR1C4

DIOPT Version :10

• Sequence 1: NP_610235.1
• Gene: CG9436 / 35586
• FlyBaseID: FBgn0033101
• Length: 311
• Species: Drosophila melanogaster
• Sequence 2: NP_001809.4
• Gene: AKR1C4 / 1109
• HGNCID: 387
• Length: 323
• Species: Homo sapiens
• Alignment Length: 319
• Identity: 130/319 - (40%)
• Similarity: 180/319 - (56%)
• Gaps: 18/319 - (5%)

  Fly     8 IRLNNGREMPTLGLGTWKSFE---SDAYHSTRHALDVGYRHLDTAFVYENEAEVGQAISEKIAEG 69
            :.||:|..||.||.||:...|   :.|...|:.|::.|:||:|:|::|.||.:||.||..|||:|
Human     8 VELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRSKIADG 72

  Fly    70 VVTREEVFVTTKLGGIHHDPALVERACRLSLSNLGLEYVDLYLMHMPVGQK-----FHNDSNVHG 129
            .|.||::|.|:||......|.:|:.|...||..|.|:||||||:|.|:..|     ...|.|  |
Human    73 SVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGETPLPKDEN--G 135

  Fly   130 TLELTDVDYLDTWREMEKLVDLGLTRSIGLSNFNAAQTERVL--ANCRIRPVVNQVECHPGFQQR 192
            .:....||...||..|||..|.||.:|||:||||..|.|.:|  ...:.:||.|||||||...|.
Human   136 KVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPVCNQVECHPYLNQS 200

  Fly   193 QLREHAKRHGLVICAYCPLARPQPARQW-----PPFLYDEHAQNLAKKYGRTTAQICLRYLVQLG 252
            :|.:..|...:|:.|:..|. .|..:.|     |..|.|.....||||:.:|.|.|.|||.:|.|
Human   201 KLLDFCKSKDIVLVAHSALG-TQRHKLWVDPNSPVLLEDPVLCALAKKHKQTPALIALRYQLQRG 264

  Fly   253 VVPLPKSSNKARIEENFRVFDFELSPDDVAGMEQYHTGQRTVPFSGMSGHKYYPFNDEF 311
            ||.|.||.|:.||.||.:||:|:|:.:|:..::..:...|.|....:..|..|||:||:
Human   265 VVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYRYVVMDFLMDHPDYPFSDEY 323

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9436	NP_610235.1	AKR_AKR2E1-5	6..294	CDD:381342	123/300 (41%)
AKR1C4	NP_001809.4	AKR_AKR1C1-35	6..306	CDD:381334	123/300 (41%)