DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eb1 and dnmt3ba

DIOPT Version :9

Sequence 1:	NP_724495.2	Gene:	Eb1 / 35584	FlyBaseID:	FBgn0027066	Length:	297	Species:	Drosophila melanogaster
Sequence 2:	XP_005167049.1	Gene:	dnmt3ba / 321084	ZFINID:	ZDB-GENE-050314-4	Length:	1500	Species:	Danio rerio

Alignment Length:	188	Identity:	62/188 - (32%)
Similarity:	106/188 - (56%)	Gaps:	27/188 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAVNV-YSTNVTSENLSRHDMLAWVNDCLQSQFSKIEELCTGAAYCQFMDMLFPNSVPVKRVKFR 64
            ||.|| ...|...:..||:::|.|:|:.||:.|:::|:..:||.:||.:|:|||.::.:|:|||.
Zfish     1 MATNVSLEPNNPDDKCSRYEVLGWINETLQTNFTQVEQCRSGACFCQLIDLLFPGTINLKKVKFE 65

  Fly    65 TNLEHEYIQNFKILQAGFKKMSVDKIIPVDKLIKGRFQDNFEFLQWFKKFFDANY---------- 119
            :....:::||:.:|||.|:.:.|.:.:||::|:.|:|:.||.:|:||||||.||.
Zfish    66 SQKRSDFMQNYGLLQAAFRDLEVTEPVPVNELLSGKFRPNFTYLKWFKKFFYANVKQERVYNAFE 130

  Fly   120 --DGREYDPVAQRGGVKLGNGNGHGSNGGSGVGSSNNDLHLMHRRPLQAPASGGRMPA 175
              ||:|..||..    .:.:.....|:..||.....:|:.:          :|||..|
Zfish   131 ARDGQEIVPVDD----VMKSPKALKSSYESGRAGEESDMEI----------NGGRRSA 174

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eb1	NP_724495.2	BIM1	16..293	CDD:227542	57/172 (33%)
		CH	16..114	CDD:278723	39/97 (40%)
		EB1	241..279	CDD:281288
dnmt3ba	XP_005167049.1	CH	16..>91	CDD:278723	28/74 (38%)
		Dnmt3b_related	902..985	CDD:99896
		PHD_SF	1078..1197	CDD:304600
		AdoMet_MTases	1222..1490	CDD:302624
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5217
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810