DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eb1 and mal3

DIOPT Version :9

Sequence 1:	NP_724495.2	Gene:	Eb1 / 35584	FlyBaseID:	FBgn0027066	Length:	297	Species:	Drosophila melanogaster
Sequence 2:	NP_593678.1	Gene:	mal3 / 2542123	PomBaseID:	SPAC18G6.15	Length:	308	Species:	Schizosaccharomyces pombe

Alignment Length:	282	Identity:	94/282 - (33%)
Similarity:	149/282 - (52%)	Gaps:	35/282 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SRHDMLAWVNDCLQSQFSKIEELCTGAAYCQFMDMLFPNSVPVKRVKFRTNLEHEYIQNFKILQA 80
            ||.::|||:|.......::||:...|.|..|..|.:: ..:|:|:|.|..|.|::||.|:|:||.
pombe     4 SRQELLAWINQVTSLGLTRIEDCGKGYAMIQIFDSIY-QDIPLKKVNFECNNEYQYINNWKVLQQ 67

  Fly    81 GFKKMSVDKIIPVDKLIKGRFQDNFEFLQWFKKFFDANYDGREYDPVAQRGGVKLGNGNGHGSNG 145
            .|.|..:||::..::|.:.:.|||.||:||.|:|:|..|.|.:||.:|:||  ..|..|....|.
pombe    68 VFLKKGIDKVVDPERLSRCKMQDNLEFVQWAKRFWDQYYPGGDYDALARRG--NRGPANTRVMNS 130

  Fly   146 GSG-VGSSNNDLHLMHRRPLQAPASGGRMPARVIASTAVSKVLPRTNNAAPASRINACANSTGTV 209
            .:| .|.|       .||.:   :||...|:             .|.::|..:.:::.||:...:
pombe   131 SAGATGPS-------RRRQV---SSGSSTPS-------------MTKSSANNNNVSSTANTAAVL 172

  Fly   210 KKNDVSNSVNNQQIEEMSNQVMDMRINLEGLEKERDFYFSKLRDIEILCQ---EADDAEAHPIIQ 271
            :....     .|||..:..|:.::...:.|||:||||||:|||:||||.|   .........:::
pombe   173 RAKQA-----QQQITSLETQLYEVNETMFGLERERDFYFNKLREIEILVQTHLTTSPMSMENMLE 232

  Fly   272 KILDILYATEDGFAPPDDAPPE 293
            :|..|||:|||||..|.|.|.:
pombe   233 RIQAILYSTEDGFELPPDQPAD 254

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eb1	NP_724495.2	BIM1	16..293	CDD:227542	94/280 (34%)
		CH	16..114	CDD:278723	37/97 (38%)
		EB1	241..279	CDD:281288	18/40 (45%)
mal3	NP_593678.1	BIM1	1..308	CDD:227542	94/282 (33%)
		CH	3..81	CDD:278723	28/77 (36%)
		EB1	199..240	CDD:281288	18/40 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	89	1.000	Domainoid score	I2088
eggNOG	1	0.900	-	-		E1_COG5217
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	155	1.000	Inparanoid score	I1277
OMA	1	1.010	-	-		QHG56844
OrthoFinder	1	1.000	-	-		FOG0000490
OrthoInspector	1	1.000	-	-		otm47289
orthoMCL	1	0.900	-	-		OOG6_100898
Panther	1	1.100	-	-	LDO	PTHR10623
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4252
SonicParanoid	1	1.000	-	-		X303
TreeFam	1	0.960	-	-
	13	12.860