DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eb1 and ebp-2

DIOPT Version :9

Sequence 1:	NP_724495.2	Gene:	Eb1 / 35584	FlyBaseID:	FBgn0027066	Length:	297	Species:	Drosophila melanogaster
Sequence 2:	NP_496438.1	Gene:	ebp-2 / 174744	WormBaseID:	WBGene00012156	Length:	299	Species:	Caenorhabditis elegans

Alignment Length:	299	Identity:	104/299 - (34%)
Similarity:	162/299 - (54%)	Gaps:	22/299 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAVNVYSTNVTSENLSRHDMLAWVNDCLQSQFSKIEELCTGAAYCQFMDMLFPNSVPVKRVKFRT 65
            |.|||:.:.||::.|||.:.:||||:.|:|.|:|:||:.:||||||...:|| |::.:|:|||..
Worm     1 MVVNVFISAVTTDTLSRKEAVAWVNNLLKSHFTKVEEMASGAAYCQLTHLLF-NAINLKKVKFNP 64

  Fly    66 NLEHEYIQNFKILQAGFKKMSVDKIIPVDKLIKGRFQDNFEFLQWFKKFFDANY--DGREYDPVA 128
            ..|.:.:.|:|:|...:|.:.:||.:.|:|:.|.:||||.||||||.||::||.  :..|||.|.
Worm    65 RSEPDVLNNWKVLTTTWKDLGIDKPVDVEKMKKAKFQDNMEFLQWFYKFYNANLTTEPEEYDAVG 129

  Fly   129 QRGGVKLGNGNGHGSNGGSGVGSSNNDLHLMHRRPLQAPASGGRMPARVIASTAVSKVLPRT--N 191
            .|.|..|....  ||.|...|.:.        .||:.|.....|..|..:|:.||...:|.|  |
Worm   130 ARFGEDLPALK--GSTGSRPVAAP--------ARPVAAAPPKPRPAAPAVAAPAVKASVPPTVRN 184

  Fly   192 NAAPASRINACANSTGTVKKN-DVSNSVNNQQIEEMSNQVMDMRINLEGLEKERDFYFSKLRDIE 255
            ...||.     |.|.||.:.: ..|..:..|:||:......:.....:.:|.||::|:|.|:.:|
Worm   185 GTRPAP-----ATSAGTRRADPSASEELLKQEIEKHKAASDEWETTAKEMETEREYYYSILQRVE 244

  Fly   256 ILCQEADDAEAHPI-IQKILDILYATEDGFAPPDDAPPE 293
            .|..||:::.:..: :..:..||||..:.....|:...|
Worm   245 SLANEAEESGSSTVDVAALKTILYAGNEDTEQVDEIENE 283

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eb1	NP_724495.2	BIM1	16..293	CDD:227542	96/282 (34%)
		CH	16..114	CDD:278723	45/97 (46%)
		EB1	241..279	CDD:281288	12/38 (32%)
ebp-2	NP_496438.1	CH	16..113	CDD:278723	45/97 (46%)
ebp-2	NP_496438.1	EB1	230..269	CDD:281288	12/38 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166339
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5217
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1295
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1237523at2759
OrthoFinder	1	1.000	-	-		FOG0000490
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100898
Panther	1	1.100	-	-	LDO	PTHR10623
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X303
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.700