DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eb1 and Mapre1

DIOPT Version :9

Sequence 1:	NP_724495.2	Gene:	Eb1 / 35584	FlyBaseID:	FBgn0027066	Length:	297	Species:	Drosophila melanogaster
Sequence 2:	NP_612518.2	Gene:	Mapre1 / 114764	RGDID:	621781	Length:	268	Species:	Rattus norvegicus

Alignment Length:	308	Identity:	164/308 - (53%)
Similarity:	206/308 - (66%)	Gaps:	51/308 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAVNVYSTNVTSENLSRHDMLAWVNDCLQSQFSKIEELCTGAAYCQFMDMLFPNSVPVKRVKFRT 65
            ||||||||:|||:||||||||||:|:.||...:|||:||:|||||||||||||.|:.:|:|||:.
  Rat     1 MAVNVYSTSVTSDNLSRHDMLAWINESLQLNLTKIEQLCSGAAYCQFMDMLFPGSIALKKVKFQA 65

  Fly    66 NLEHEYIQNFKILQAGFKKMSVDKIIPVDKLIKGRFQDNFEFLQWFKKFFDANYDGREYDPVAQR 130
            .|||||||||||||||||:|.||||||||||:||:|||||||:|||||||||||||:||||||.|
  Rat    66 KLEHEYIQNFKILQAGFKRMGVDKIIPVDKLVKGKFQDNFEFVQWFKKFFDANYDGKEYDPVAAR 130

  Fly   131 GGVKLGNGNGHGSNGGSGVGSSNNDLHLMHRRPLQAPA---------SGGRMPARVIASTAVSKV 186
            .|.:            :.|..|           |.|||         ||...|.|.||:
  Rat   131 QGQE------------TAVAPS-----------LVAPALSKPKKPLGSGSAAPQRPIAT------ 166

  Fly   187 LPRTNNAAPASRINACANSTGTVKKNDVSNSVNNQQIEEMSNQVMDMRINLEGLEKERDFYFSKL 251
              :...|||.:       ..|.|:||....: .:.:..|:..||..:::.:|.|||||||||.||
  Rat   167 --QRTTAAPKA-------GPGMVRKNPGMGN-GDDEAAELMQQVKVLKLTVEDLEKERDFYFGKL 221

  Fly   252 RDIEILCQEADDAEAHPIIQKILDILYATEDGFAPPDDAPP--EDEEY 297
            |:||::||| ::.|..|::|:|:||||||::||..||:..|  |.|||
  Rat   222 RNIELICQE-NEGENDPVLQRIVDILYATDEGFVIPDEGGPQEEQEEY 268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eb1	NP_724495.2	BIM1	16..293	CDD:227542	147/287 (51%)
		CH	16..114	CDD:278723	75/97 (77%)
		EB1	241..279	CDD:281288	23/37 (62%)
Mapre1	NP_612518.2	BIM1	16..257	CDD:227542	144/280 (51%)
		Interaction with MTUS2/TIP150. /evidence=ECO:0000250	124..268		64/183 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	146..191		13/60 (22%)
		DCTN1-binding. /evidence=ECO:0000250	208..268		35/60 (58%)
		APC-binding. /evidence=ECO:0000250	220..242		11/22 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352815
Domainoid	1	1.000	180	1.000	Domainoid score	I3411
eggNOG	1	0.900	-	-		E1_COG5217
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	302	1.000	Inparanoid score	I2590
OMA	1	1.010	-	-		QHG56844
OrthoDB	1	1.010	-	-		D1237523at2759
OrthoFinder	1	1.000	-	-		FOG0000490
OrthoInspector	1	1.000	-	-		otm45639
orthoMCL	1	0.900	-	-		OOG6_100898
Panther	1	1.100	-	-	LDO	PTHR10623
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X303
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.770