Protein Alignment Eb1 and Mapre3

DIOPT Version :10

• Sequence 1: NP_724495.2
• Gene: Eb1 / 35584
• FlyBaseID: FBgn0027066
• Length: 297
• Species: Drosophila melanogaster
• Sequence 2: NP_579928.1
• Gene: Mapre3 / 100732
• MGIID: 2140967
• Length: 281
• Species: Mus musculus
• Alignment Length: 301
• Identity: 155/301 - (51%)
• Similarity: 204/301 - (67%)
• Gaps: 32/301 - (10%)

  Fly     1 MAVNVYSTNVTSENLSRHDMLAWVNDCLQSQFSKIEELCTGAAYCQFMDMLFPNSVPVKRVKFRT 65
            ||||||||:|||||||||||||||||.|...::|||:||:|||||||||||||..|.:::|||:.
Mouse     1 MAVNVYSTSVTSENLSRHDMLAWVNDSLHLNYTKIEQLCSGAAYCQFMDMLFPGCVHLRKVKFQA 65

  Fly    66 NLEHEYIQNFKILQAGFKKMSVDKIIPVDKLIKGRFQDNFEFLQWFKKFFDANYDGREYDPVAQR 130
            .||||||.|||:|||.||||.|||||||:||:||:|||||||:|||||||||||||::|:|:..|
Mouse    66 KLEHEYIHNFKVLQAAFKKMGVDKIIPVEKLVKGKFQDNFEFIQWFKKFFDANYDGKDYNPLLAR 130

  Fly   131 GGVKLGNGNGHGSNGGSGVGSSNNDLHLMHRRPLQAPASGGRMPARVIASTAVS-KVLPRTNNAA 194
            .|..:    ....|.|..:.:.:..|            .|..:|.|...:...: :...|.:|.|
Mouse   131 QGQDV----APPPNPGDQIFNKSKKL------------IGTAVPQRTSPTGPKNMQTSGRLSNVA 179

  Fly   195 PASRINACANSTGTVKKNDVS----NSVNNQQIEEMSNQVMDMRINLEGLEKERDFYFSKLRDIE 255
            |     .|     .::||..|    ....:.||.|::.|::|:::.::|||||||||||||||||
Mouse   180 P-----PC-----ILRKNPPSARNGGHEADAQILELNQQLLDLKLTVDGLEKERDFYFSKLRDIE 234

  Fly   256 ILCQEADDAEAHPIIQKILDILYATEDGFAPPDDAPPEDEE 296
            ::||| .::|..|:|..|:.||||||:|||||:|...|:.:
Mouse   235 LICQE-HESENSPVISGIIGILYATEEGFAPPEDDEIEEHQ 274

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eb1	NP_724495.2	BIM1	16..293	CDD:227542	140/281 (50%)
Mapre3	NP_579928.1	BIM1	16..279	CDD:227542	141/286 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	157..181		6/28 (21%)
		DCTN1-binding. /evidence=ECO:0000250	217..281		37/59 (63%)
		APC-binding. /evidence=ECO:0000250	217..260		29/43 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	260..281		7/15 (47%)