DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment phtf and Phtf1

DIOPT Version :9

Sequence 1:	NP_610232.1	Gene:	phtf / 35583	FlyBaseID:	FBgn0028579	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_001156939.1	Gene:	Phtf1 / 18685	MGIID:	1332671	Length:	761	Species:	Mus musculus

Alignment Length:	933	Identity:	287/933 - (30%)
Similarity:	438/933 - (46%)	Gaps:	238/933 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EIVAWYQKRIGTYDKQEWEKTVEQRILDGFNSVNLKNTKLKTELIDVDLVRGSTFPKAKPKQSLL 69
            :.::||||:||.||:|.|||::||..:.||.:...|...:|.:||||||:|||||.||||:....
Mouse     7 DAISWYQKKIGAYDQQIWEKSIEQTQIKGFKNKPKKMGHIKPDLIDVDLIRGSTFAKAKPEIPWT 71

  Fly    70 TVIRLAILRYVLLPLYAQWWVKQTTPNAFGFILVLYLTQLTNWAIYVLHSSRIVPLDYEKPPNGT 134
            ::.|..::|.|..||::.||::.|:...|.::|:|||.|:|...:|:|     :|:
Mouse    72 SLTRKGLVRVVFFPLFSSWWIQVTSLRIFVWLLLLYLMQVTAVVLYLL-----MPI--------- 122

  Fly   135 LLQAEADGDASDKDADKESEEHAALLSALLIPCALSLLISLIHSQIVATNTA--SGVSGGSSKNK 197
                                   ...|.:|.|..|.||:..:|.|||:|...  ||.:|...:.|
Mouse   123 -----------------------VSASEVLGPLCLMLLMGTVHCQIVSTQITRPSGNNGNRRRRK 164

  Fly   198 LRRISASYLSDKAATRENRVRRRKKIVRVRQVEADLSQASSNISLPNRRTATSTIEVLPRPVTPL 262
            ||                           :.|..|.|:.:.|.| |::..|..|:|
Mouse   165 LR---------------------------KTVNGDGSRDNGNNS-PDKVRAVETLE--------- 192

  Fly   263 PSPTVTCATVPDPTTPTTPSPSV--------------IRRSTNEETYLTTTAISPLTQPLAAIDA 313
                              .:.||              ::..:|:.|.....:            .
Mouse   193 ------------------SASSVGGFWGTLFGNRIKRVKLVSNKGTETDNDS------------G 227

  Fly   314 CYDLSRKAGGAAPE-----SPKKRNVNWHTPIQIYATYELGEEPCSSRKVAEESAPESVGERLCS 373
            |:....|.....||     :.:|..|:.....:..|...||      ..::::.:.|..||....
Mouse   228 CFHPILKKRQGRPEIRMWQAREKAKVSDGEKCRREAYRRLG------NGISDDLSSEEDGEARTQ 286

  Fly   374 VKPDYQTRRNI---GEDDGFESLNGKSSSGEDNNHSPLPNAVAVAAPPAPVQTNQLRLRLNTTNG 435
            :   ...||::   ..|:|:|..|.:|......|                   :|::......:.
Mouse   287 M---ILLRRSVEGASSDNGYEVKNRRSILSRHLN-------------------SQVKKTTRWCHI 329

  Fly   436 VTASASPTEKKPQS----------------------RGNESSTSCAESDECDDADIMSSPASGCN 478
            |..|.|..|.:.:|                      |.:||:...:|:::....|::..|
Mouse   330 VRDSDSLAESEFESAVFSQGSRSGMSGGSRSLNLSRRDSESTRHDSETEDMLWDDLLHGP----- 389

  Fly   479 QECTTSATDWLGVTTNSEDCSYTSDLDHSDGGLKHTAFSDEDPGELDITPTTIL----NPHSSLD 539
             ||.:|      ||::||.....:  .||  |.|      .||.| |:.....|    |...:.:
Mouse   390 -ECRSS------VTSDSEGAHVNT--IHS--GTK------RDPKE-DVFQQNHLFWLQNSSPASE 436

  Fly   540 RISCTIWDQRDAKKAQLSVLEIASCIIERVDSMGEANDYIYIGVVFSFLLTLIPIFCRLCEVTLG 604
            |:|..||:..:.||..:|||||:..|:.||::..:...|..:|...:..|.|.|...||..
Mouse   437 RVSAIIWEGNECKKMDMSVLEISGIIMSRVNAYEQGVGYQMLGNAVTVGLALFPFLYRLFR---- 497

  Fly   605 SDAEKASEISYFNMPQLLWEKSSASLFTLLGLAFGDSQWERMVL--ALGFVQRLCLTLILFIIFA 667
               ||:.:           :..|.|...:|.|..|......:|:  .:.|::|||||.:.|.:..
Mouse   498 ---EKSFD-----------QLKSISAEEVLTLFCGAPPVTPVVILSIINFIERLCLTWMFFFMMC 548

  Fly   668 VAERTFKQRFLYAKLFSHLTSSRRARKSNLPHFRLNKVRNIKTWLSVRSYLKKRGPQRSVDIIVS 732
            |||||:|||||:||||||:||:|:|||..:|||||.||.|||.|||:|||||:||||||||::||
Mouse   549 VAERTYKQRFLFAKLFSHITSARKARKYEIPHFRLKKVENIKIWLSLRSYLKRRGPQRSVDVVVS 613

  Fly   733 AAFIVTLLLLAFLSVEWLKDSAHLHTHLTL-------EALIWSITIGIFLLRFMTLGQKIQHKYR 790
            :.|::|      ||:.::..:..|..|.|.       |.|||...:.:||||..:||.:...||.
Mouse   614 SVFLLT------LSIAFICCAQVLQGHKTFLNDAYNWEFLIWETALLLFLLRLASLGSETNKKYS 672

  Fly   791 SVSVLITEQINLYLQIEQKPKKKDELMVSNSVLKLAADLLKELETPFKLSGLSANPYLFTTIKVV 855
            :||:|:||||||||::|:||.||::|.:.|:||||:..|||||:|||:|.||:.||.::...:||
Mouse   673 NVSILLTEQINLYLKMEKKPNKKEQLTLVNNVLKLSTKLLKELDTPFRLYGLTMNPLIYNITRVV 737

  Fly   856 ILSALSGVLSEVLGFKLKLHKIK 878
            ||||:|||:|::|||.::|.|||
Mouse   738 ILSAVSGVISDLLGFNIRLWKIK 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phtf	NP_610232.1	Phtf-FEM1B_bdg	3..184	CDD:288944	61/178 (34%)
Phtf1	NP_001156939.1	Phtf-FEM1B_bdg	5..149	CDD:288944	61/178 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	152..184		12/59 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	345..414		17/90 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849402
Domainoid	1	1.000	307	1.000	Domainoid score	I1341
eggNOG	1	0.900	-	-		E1_28I6J
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	426	1.000	Inparanoid score	I1738
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47584
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004060
OrthoInspector	1	1.000	-	-		otm42838
orthoMCL	1	0.900	-	-		OOG6_104992
Panther	1	1.100	-	-	LDO	PTHR12680
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2811
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.760