Protein Alignment phtf and PHTF1

DIOPT Version :10

• Sequence 1: NP_610232.1
• Gene: phtf / 35583
• FlyBaseID: FBgn0028579
• Length: 880
• Species: Drosophila melanogaster
• Sequence 2: NP_006599.2
• Gene: PHTF1 / 10745
• HGNCID: 8939
• Length: 762
• Species: Homo sapiens
• Alignment Length: 943
• Identity: 294/943 - (31%)
• Similarity: 433/943 - (45%)
• Gaps: 257/943 - (27%)

  Fly     5 EIVAWYQKRIGTYDKQEWEKTVEQRILDGFNSVNLKNTKLKTELIDVDLVRGSTFPKAKPKQSLL 69
            :.::||||:||.||:|.|||::||..:.|..:...|...:|.:||||||:|||||.||||:....
Human     7 DAISWYQKKIGAYDQQIWEKSIEQTQIKGLKNKPKKMGHIKPDLIDVDLIRGSTFAKAKPEIPWT 71

  Fly    70 TVIRLAILRYVLLPLYAQWWVKQTTPNAFGFILVLYLTQLTNWAIYVLHSSRIVPLDYEKPPNGT 134
            ::.|..::|.|..||::.||::.|:...|.::|:||..|:....:|::     :|:
Human    72 SLTRKGLVRVVFFPLFSNWWIQVTSLRIFVWLLLLYFMQVIAIVLYLM-----MPI--------- 122

  Fly   135 LLQAEADGDASDKDADKESEEHAALLSALLIPCALSLLISLIHSQIVATNTA--SGVSGGSSKNK 197
                                   ..:|.:|.|..|.||:..:|.|||:|...  ||.:|...:.|
Human   123 -----------------------VNISEVLGPLCLMLLMGTVHCQIVSTQITRPSGNNGNRRRRK 164

  Fly   198 LR--------RISASYLSDKAATRE-----------------NRVRRRKKIVRVRQVEADLSQAS 237
            ||        |.:.:..|||....|                 ||::|.|.|
Human   165 LRKTVNGDGSRENGNNSSDKVRGIETLESVPIIGGFWETIFGNRIKRVKLI-------------- 215

  Fly   238 SNISLPNRRTATSTIEVLPRPVTPLPSPTVTCATVPDPTTPTTPSPSVIRRSTNEETYLTTTAIS 302
                 .|:.|.|.                         ..|:...|.:.||....|..:
Human   216 -----SNKGTETD-------------------------NDPSCVHPIIKRRQCRPEIRM------ 244

  Fly   303 PLTQPLAAIDACYDLSRKAGGAAPESPKKRNVNWHTPIQIYATYELGEEPCSSRKVAEESAPESV 367
                                             |.|  :..|.:..||: |  |:.|.......|
Human   245 ---------------------------------WQT--REKAKFSDGEK-C--RREAFRRLGNGV 271

  Fly   368 GERLCSVKPDYQTRRNIGEDDG---------FESLNGKSSSGEDNNHSPLPNAVAVAAPPAPVQT 423
            .:.|.|            |:||         ..|:.|.||    :|...:.|..::.:.....|.
Human   272 SDDLSS------------EEDGEARTQMILLRRSVEGASS----DNGCEVKNRKSILSRHLNSQV 320

  Fly   424 NQLRLR----------LNTTNGVTASASPTEKKPQSRGNES-------STSCAESDECDDA---D 468
            .:...|          |..:...:|:.|...:...|.|:.|       |.|.....|.:|.   |
Human   321 KKTTTRWCHIVRDSDSLAESEFESAAFSQGSRSGVSGGSRSLNMSRRDSESTRHDSETEDMLWDD 385

  Fly   469 IMSSPASGCNQECTTSATDWLGVTTNSEDCSYTSDLDHSDGGLKHTAFSDEDPGELDITPTTIL- 532
            ::..|      ||.:|      ||::||. ::.:.| ||  |.|      .||.| |:.....|
Human   386 LLHGP------ECRSS------VTSDSEG-AHVNTL-HS--GTK------RDPKE-DVFQQNHLF 427

  Fly   533 ---NPHSSLDRISCTIWDQRDAKKAQLSVLEIASCIIERVDSMGEANDYIYIGVVFSFLLTLIPI 594
               |...|.||:|..||:..:.||..:|||||:..|:.||::..:...|..:|.|.:..|...|.
Human   428 WLQNSSPSSDRVSAIIWEGNECKKMDMSVLEISGIIMSRVNAYQQGVGYQMLGNVVTIGLAFFPF 492

  Fly   595 FCRLCEVTLGSDAEKASEISYFNMPQLLWEKSSASLFTLLGLAFGDSQWERMVL--ALGFVQRLC 657
            ..||..       ||       ::.||    .|.|...:|.|..|......:::  .:.|.:|||
Human   493 LHRLFR-------EK-------SLDQL----KSISAEEILTLFCGAPPVTPIIVLSIINFFERLC 539

  Fly   658 LTLILFIIFAVAERTFKQRFLYAKLFSHLTSSRRARKSNLPHFRLNKVRNIKTWLSVRSYLKKRG 722
            ||.:.|.:..|||||:|||||:||||||:||:|:|||..:|||||.||.|||.|||:|||||:||
Human   540 LTWMFFFMMCVAERTYKQRFLFAKLFSHITSARKARKYEIPHFRLKKVENIKIWLSLRSYLKRRG 604

  Fly   723 PQRSVDIIVSAAFIVTLLLLAFLSVEWLKDSAHLHTHLTL-------EALIWSITIGIFLLRFMT 780
            ||||||::||:.|::|      ||:.::..:..|..|.|.       |.|||...:.:||||..:
Human   605 PQRSVDVVVSSVFLLT------LSIAFICCAQVLQGHKTFLNDAYNWEFLIWETALLLFLLRLAS 663

  Fly   781 LGQKIQHKYRSVSVLITEQINLYLQIEQKPKKKDELMVSNSVLKLAADLLKELETPFKLSGLSAN 845
            ||.:...||.:||:|:||||||||::|:||.||::|.:.|:||||:..|||||:|||:|.||:.|
Human   664 LGSETNKKYSNVSILLTEQINLYLKMEKKPNKKEQLTLVNNVLKLSTKLLKELDTPFRLYGLTMN 728

  Fly   846 PYLFTTIKVVILSALSGVLSEVLGFKLKLHKIK 878
            |.::...:||||||:|||:|::|||.::|.|||
Human   729 PLIYNITRVVILSAVSGVISDLLGFNIRLWKIK 761

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
phtf	NP_610232.1	PHTF1-2_N	1..185	CDD:463466	58/179 (32%)
PHTF1	NP_006599.2	PHTF1-2_N	3..149	CDD:463466	57/178 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	152..184		8/31 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	344..380		8/35 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	393..415		10/37 (27%)