Protein Alignment chk and SLC16A4

DIOPT Version :9

• Sequence 1: NP_001163063.1
• Gene: chk / 35578
• FlyBaseID: FBgn0033095
• Length: 894
• Species: Drosophila melanogaster
• Sequence 2: NP_004687.1
• Gene: SLC16A4 / 9122
• HGNCID: 10925
• Length: 487
• Species: Homo sapiens
• Alignment Length: 754
• Identity: 152/754 - (20%)
• Similarity: 250/754 - (33%)
• Gaps: 295/754 - (39%)

  Fly   131 KMPDGGYGWVVVFASLVVSLIADGLSFSFGLINVELLEYFGESTSKTAWISSLFFSVPLLMGPIW 195
            |..|||:||::|....:|::...|::.:|.:..|...|.|..::.:..||.|:..|:....||:.
Human    13 KTLDGGWGWMIVIHFFLVNVFVMGMTKTFAIFFVVFQEEFEGTSEQIGWIGSIMSSLRFCAGPLV 77

  Fly   196 SNLVDKYGCRKMTILGGVVSAFGFALSSFCNSIEMLMVTFGIISGLGLGIGYVTAVVSIAFWFDK 260
            :.:.|..|.:..:|||..|...|:.:||:..||..|.||.|::.|||....|..|.|....:|.|
Human    78 AIICDILGEKTTSILGAFVVTGGYLISSWATSIPFLCVTMGLLPGLGSAFLYQVAAVVTTKYFKK 142

  Fly   261 KRTFATGIGASGTGIGTFVYARLTSYLIESYGWRGATLILGGTMLNACVCGALMRDPDWLIEENR 325
            :...:|.|..||.|: ||:.|..|.:||:.|.|.||.::.|...||......|:|
Human   143 RLALSTAIARSGMGL-TFLLAPFTKFLIDLYDWTGALILFGAIALNLVPSSMLLR---------- 196

  Fly   326 LESRSQSVTTFSNSSVCLEEIKKLLDTGITKEAVLDSLVTKNNTEANQQIDDPLDSALKRYRSEI 390
                                                                |:
Human   197 ----------------------------------------------------PI----------- 198

  Fly   391 FLPTFLSTQELDSICEVKSLSRRSLRHKEGEEAPSRENLLSMSSGAGAYPPSTAVIGSPDDTLMG 455
                           .:||.:...::.|              .|...|:.|
Human   199 ---------------HIKSENNSGIKDK--------------GSSLSAHGP-------------- 220

  Fly   456 GIAHEAAEEAKKAYLASIETLSPSEKRSTGRTPNGSLRSSDEGYLTQKHASSRYSLNENIFMAKH 520
                                                          :.||:
Human   221 ----------------------------------------------EAHAT-------------- 225

  Fly   521 TTPSISNLKVNGLRHNSVDILSEDMHCYYSKDETFALLEPSRRIRPTVIAIPEQEQSVNSELATR 585
                                   :.||:                        |.|:|...:..|:
Human   226 -----------------------ETHCH------------------------ETEESTIKDSTTQ 243

  Fly   586 RARLDSITGIRRLSRSKKPSHHRSNLRRNISIRNSNFLKDMRIHRNSIHYRGAMLNTHRYRLRAS 650
            :|.|.|                     :|:::..         :::...|.|
Human   244 KAGLPS---------------------KNLTVSQ---------NQSEEFYNG------------- 265

  Fly   651 SCPNIYRNSMTTIAKEEED---TWYDNFVDTMKSIFDFSLFLDMKFALFNLSTLFLFIWFIIPYL 712
              ||  ||.:...:.||.|   :|      :.|.:||.|||.:..|.:|..|.|...:.:.||..
Human   266 --PN--RNRLLLKSDEESDKVISW------SCKQLFDISLFRNPFFYIFTWSFLLSQLAYFIPTF 320

  Fly   713 YLPDYMKQYKYDVSQSAELISDVGIAQTVGMIGLGYLGDLSWMNINICYSLCMLVCGASVFFMPL 777
            :|....|....|:..::.|:|..||.:||..|..|::.|.:|:.....:...:::||.:....|
Human   321 HLVARAKTLGIDIMDASYLVSVAGILETVSQIISGWVADQNWIKKYHYHKSYLILCGITNLLAP- 384

  Fly   778 LITNYMGLMVMCVIFGFTFASSFSFTPSILVSIVDLDDFTCA-------YGLVLLVQGVGMIAGP 835
            |.|.:..||...:.|.. ||.  .:...||..:|||    |.       .||.....|:.:::||
Human   385 LATTFPLLMTYTICFAI-FAG--GYLALILPVLVDL----CRNSTVNRFLGLASFFAGMAVLSGP 442

  Fly   836 PIAGVIYEYTGRWDDTFYYAGIFIALSGVCSYLIEFCEK 874
            ||||.:|:||..::.:||::||...||.|..:.:...|:
Human   443 PIAGWLYDYTQTYNGSFYFSGICYLLSSVSFFFVPLAER 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
chk	NP_001163063.1	MFS	143..>315	CDD:119392	54/171 (32%)
		MFS	<685..869	CDD:119392	57/190 (30%)
SLC16A4	NP_004687.1	MFS	24..477	CDD:119392	145/737 (20%)
		MFS_1	27..442	CDD:284993	128/699 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	206..250		15/199 (8%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	79	1.000	Domainoid score	I8661
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	1	1.000	-	-		mtm8605
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11360
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4139
SonicParanoid	1	1.000	-	-		X70
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.940