Protein Alignment chk and SLC16A5

DIOPT Version :9

• Sequence 1: NP_001163063.1
• Gene: chk / 35578
• FlyBaseID: FBgn0033095
• Length: 894
• Species: Drosophila melanogaster
• Sequence 2: XP_005257847.1
• Gene: SLC16A5 / 9121
• HGNCID: 10926
• Length: 545
• Species: Homo sapiens
• Alignment Length: 791
• Identity: 146/791 - (18%)
• Similarity: 241/791 - (30%)
• Gaps: 380/791 - (48%)

  Fly   126 EKKTPKMP------DGGYGWVVVFASLVVSLIADGLSFSFGLINVELLEYFGESTSKTAWISSLF 184
            :::..:||      ||.:.|||:.|::|...:..|.....|:...||...|..|.|:|:|..|:.
Human    35 QRRQQRMPQALERADGSWAWVVLLATMVTQGLTLGFPTCIGIFFTELQWEFQASNSETSWFPSIL 99

  Fly   185 FSVPLLMGPIWSNLVDKYGCRKMTILGGVVSAFGFALSSFCNSIEMLMVTFGIISGLGLGIGYVT 249
            .:|..:.||:.|.||.::|||...:||||:::.|...|||.:::..|..|.|.|:|||:...:.:
Human   100 TAVLHMAGPLCSILVGRFGCRVTVMLGGVLASLGMVASSFSHNLSQLYFTAGFITGLGMCFSFQS 164

  Fly   250 AVVSIAFWFDKKRTFATGIGASGTGIGTFVYARLTSYLIESYGWRGATLILGGTMLNACVCGALM 314
            ::..:.|:|.::|..|..:.:.|..:|..::..|:.||:|:.||||..|:.||..|:.|:|||::
Human   165 SITVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLENLGWRGTFLVFGGIFLHCCICGAII 229

  Fly   315 RDPDWLIEENRLESRSQSVTTFSNSSVCLEEIKKLLDTGITKEAVLDSLVTKNNTEANQQIDDPL 379
            |                                                              |:
Human   230 R--------------------------------------------------------------PV 232

  Fly   380 DSALKRYRSEIFLPTFLSTQELDSICEVKSLSRRSLRHKEGEEAPSRENLLSMSSGAGAYPPSTA 444
            .:::.                                 .|.:|.|..             ||.|.
Human   233 ATSVA---------------------------------PETKECPPP-------------PPETP 251

  Fly   445 VIGSPDDTLMGGIAHEAAEEAKKAYLASIETLSPSEKRSTGRTPNGSLRSSDEGYLTQKHASSRY 509
            .:|.                     ||           :.|||             .|:|
Human   252 ALGC---------------------LA-----------ACGRT-------------IQRH----- 266

  Fly   510 SLNENIFMAKHTTPSISNLKVNGLRHNSVDILSEDMHCYYSKDETFALLEPSRRIRPTVIAIPEQ 574
                              |..:.||||:       .:|.|
Human   267 ------------------LAFDILRHNT-------GYCVY------------------------- 281

  Fly   575 EQSVNSELATRRARLDSITGIRRLSRSKKPSHHRSNLRRNISIRNSNFLKDMRIHRNSIHYRGAM 639
                             |.|:
Human   282 -----------------ILGV-------------------------------------------- 285

  Fly   640 LNTHRYRLRASSCPNIYRNSMTTIAKEEEDTWYDNFVDTMKSIFDFSLFLDMKFALFNLSTLFLF 704
                                                   |.|:..|.|
Human   286 ---------------------------------------MWSVLGFPL----------------- 294

  Fly   705 IWFIIPYLYLPDYMKQYKYDVSQSAELISDVGIAQTV--GMIGL-----------GYLGDLSWMN 756
                 |.::|..|...:..|..|:|.|||.:|.:...  .:.||           .||..|:.:
Human   295 -----PQVFLVPYAMWHSVDEQQAALLISIIGFSNIFLRPLAGLMAGRPAFASHRKYLFSLALL- 353

  Fly   757 INICYSLCMLVCGASVFFMPLLITNYMGLMVMCVIFGFTFASSFSFTP------SILVSIVDLDD 815
            :|   .|..|||.||..|.              |:.|:..|.|.|.:.      .:|:.||.:|.
Human   354 LN---GLTNLVCAASGDFW--------------VLVGYCLAYSVSMSGIGALIFQVLMDIVPMDQ 401

  Fly   816 FTCAYGLVLLVQGVGMIAGPPIAGVIYEYTGRWDDTFYYAGIFI----ALSGVCSYLIEFCEKKA 876
            |..|.||..::.|:..:..||:||::.:.|..:...||.:..|:    ...|...|.::  :|:.
Human   402 FPRALGLFTVLDGLAFLISPPLAGLLLDATNNFSYVFYMSSFFLISAALFMGGSFYALQ--KKEQ 464

  Fly   877 PKES-DSDVLE 886
            .|:: .:|.||
Human   465 GKQAVAADALE 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
chk	NP_001163063.1	MFS	143..>315	CDD:119392	58/171 (34%)
		MFS	<685..869	CDD:119392	49/206 (24%)
SLC16A5	XP_005257847.1	2A0113	41..493	CDD:273325	146/785 (19%)
		MFS	54..452	CDD:119392	135/745 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X70
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.810