Protein Alignment chk and SLC16A6

DIOPT Version :9

• Sequence 1: NP_001163063.1
• Gene: chk / 35578
• FlyBaseID: FBgn0033095
• Length: 894
• Species: Drosophila melanogaster
• Sequence 2: XP_005257846.2
• Gene: SLC16A6 / 9120
• HGNCID: 10927
• Length: 527
• Species: Homo sapiens
• Alignment Length: 755
• Identity: 139/755 - (18%)
• Similarity: 245/755 - (32%)
• Gaps: 308/755 - (40%)

  Fly   131 KMPDGGYGWVVVFASLVVSLIADGLSFSFGLINVELLEYFGESTSKTAWISSLFFSVPLLMGPIW 195
            ::||||:||.|..:...|.:...|:..:||:...:|::.|.||.|:.:||.|:...|.....|:.
Human    21 EVPDGGWGWAVAVSFFFVEVFTYGIIKTFGVFFNDLMDSFNESNSRISWIISICVFVLTFSAPLA 85

  Fly   196 SNLVDKYGCRKMTILGGVVSAFGFALSSFCNSIEMLMVTFGIISGLGLGIGYVTAVVSIAFWFDK 260
            :.|.:::|.|.:.:|||::.:.|...:||...:..:.|..|||||||....::..|..::.:|.|
Human    86 TVLSNRFGHRLVVMLGGLLVSTGMVAASFSQEVSHMYVAIGIISGLGYCFSFLPTVTILSQYFGK 150

  Fly   261 KRTFATGIGASGTGIGTFVYARLTSYLIESYGWRGATLILGGTMLNACVCGALMR--------DP 317
            :|:..|.:.::|.....|.:|.....|.|..|||.:.|.:|...||..:.|||:|        .|
Human   151 RRSIVTAVASTGECFAVFAFAPAIMALKERIGWRYSLLFVGLLQLNIVIFGALLRPIFIRGPASP 215

  Fly   318 DWLIEENRLESRSQSVTTFSNSSVCLEEIKKLLDTGITKEAVLDSLVTKNNTEANQQIDDPLDSA 382
            ..:|:|||                  :|.:.:|:...|:.::                 |.:||.
Human   216 KIVIQENR------------------KEAQYMLENEKTRTSI-----------------DSIDSG 245

  Fly   383 LKRYRSEIFLPTFLSTQELDSICEVKSLSRRSLRHKEGEEAPSRENLLSMSSGAGAYPPSTAVIG 447
            :                ||
Human   246 V----------------EL---------------------------------------------- 248

  Fly   448 SPDDTLMGGIAHEAAEEAKKAYLASIETLSPSEKRSTGRTPNGSLRSSDEGYLTQKHASSRYSLN 512
                                       |.||
Human   249 ---------------------------TTSP---------------------------------- 252

  Fly   513 ENIFMAKHTTPSISNLKVNGLRHNSVDILSEDMHCYYSKDETFALLEPSRRIRPTVIAIPEQEQS 577
            :|:       |:.:||:                            |||...::..::
Human   253 KNV-------PTHTNLE----------------------------LEPKADMQQVLV-------- 274

  Fly   578 VNSELATRRARLDSITGIRRLSRSKKPSHHRSNLRRNISIRNSNFLKDMRIHRNSIHYRGAMLNT 642
                                 ..|.:||..::.|
Human   275 ---------------------KTSPRPSEKKAPL------------------------------- 287

  Fly   643 HRYRLRASSCPNIYRNSMTTIAKEEEDTWYDNFVDTMKSIFDFSLFLDMKFALFNLSTLFLFIWF 707
                                                    .|||:..:..|..:.|..||..:.|
Human   288 ----------------------------------------LDFSILKEKSFICYALFGLFATLGF 312

  Fly   708 IIPYLYLPDYMKQYKYDVSQSAELISDVGIAQTVGMIGLGYLGDLSWMNINICY--SLCMLVCGA 770
            ..|.||:.........|..::|.|:|.:.||:..|.||.|::  |:...|...|  .:|:::...
Human   313 FAPSLYIIPLGISLGIDQDRAAFLLSTMAIAEVFGRIGAGFV--LNREPIRKIYIELICVILLTV 375

  Fly   771 SVFFMPLLITNYMGLMVMCVIFGFTFASSFSFTPSILV--SIVDLDDFTCAYGLVLLVQGVGMIA 833
            |:|.. ...|.:.|||...:.|||...:.......:|.  .:|.::..:.|.|:.:.:|.:..:|
Human   376 SLFAF-TFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAEDDVVGIEKMSSAAGVYIFIQSIAGLA 439

  Fly   834 GPPIAGVIYEYTGRWDDTFYYAGIFIALSGVCSYLIEFCE 873
            |||:||::.:.:..:...||.....:||:.||..|:..|:
Human   440 GPPLAGLLVDQSKIYSRAFYSCAAGMALAAVCLALVRPCK 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
chk	NP_001163063.1	MFS	143..>315	CDD:119392	51/171 (30%)
		MFS	<685..869	CDD:119392	50/187 (27%)
SLC16A6	XP_005257846.2	2A0113	23..512	CDD:273325	139/753 (18%)
		MFS	33..476	CDD:119392	131/738 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	1	1.000	-	-		mtm8605
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11360
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.910