DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chk and ESBP6

DIOPT Version :9

Sequence 1:	NP_001163063.1	Gene:	chk / 35578	FlyBaseID:	FBgn0033095	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_014274.1	Gene:	ESBP6 / 855598	SGDID:	S000005069	Length:	673	Species:	Saccharomyces cerevisiae

Alignment Length:	349	Identity:	90/349 - (25%)
Similarity:	141/349 - (40%)	Gaps:	71/349 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LATDPNASNNNS--------CEAVNNNHNGQNQSQ---------NGGAS----NYQALPLTPAPA 47
            |.|:.|:::.|.        .:|:...||...||:         ..|||    :..|...:....
Yeast    82 LQTEENSADVNKILESRFDVADAIRLQHNESVQSKLNIPVTHTTTAGASLSAPSSSAFSASSIQN 146

  Fly    48 NTPLHKA------IKHDLFPEVTFCNLSVEEL-ADGAGHSRVVRSSVIELEDGTMTCLMNGNGQV 105
            :|..|||      :::.|:|..|  ..|.::| |.|          :.|.|....|.
Yeast   147 DTTEHKASMDSKLMRNRLYPAST--KHSGKDLEAQG----------ITEFEPDEPTV-------- 191

  Fly   106 KRRKRLISNESGDSIDSSSTEKKTPKMPDGGYGWVVVFASLVVSLIADGLSFSFGLINVELLEYF 170
               |::.:|:|...::..         |||||||||.|...:......|.:.|||   |:|..|.
Yeast   192 ---KKVFTNKSTGQLELP---------PDGGYGWVVTFCVFLTMFSTWGCNASFG---VDLAYYL 241

  Fly   171 ------GESTSKTAWISSLFFSVPLLMGPIWSNLVDKYGCRKMTILGGVVSAFGFALSSFCNSIE 229
                  |.|....|.|:.|...:..|:.|:...|:...|.|...:.|..|....:.|:||...:.
Yeast   242 NHDTYPGASKYDYALIAGLTVFLGQLLSPLVMALMRIIGLRTTMLFGDAVMLAAYLLASFTTKLW 306

  Fly   230 MLMVTFGIISGLGLGIGYVTAVVSIAFWFDKKRTFATGIGASGTGIGTFVYARLTSYLIESYG-W 293
            .|.||.|.:.|..:.:.:|.|...:..||.|||..|.|:...|||.|..||...|:.::..:| .
Yeast   307 QLYVTQGFMVGCSISLIFVPATTVLPGWFLKKRAVAMGVSLLGTGAGGVVYGLATNKMLSDFGNT 371

  Fly   294 RGATLILG-GTMLNACVCGALMRD 316
            |....|:| ...::..|..||:::
Yeast   372 RWCLRIIGISCSISVLVAIALLKE 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chk	NP_001163063.1	MFS	143..>315	CDD:119392	51/179 (28%)
chk	NP_001163063.1	MFS	<685..869	CDD:119392
ESBP6	NP_014274.1	MFS_MCT_SLC16	212..606	CDD:340910	55/187 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	1	1.000	-	-		mtm13433
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11360
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X70
TreeFam	0	0.000	Not matched by this tool.
	6	5.910