DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chk and slc16a10

DIOPT Version :9

Sequence 1:	NP_001163063.1	Gene:	chk / 35578	FlyBaseID:	FBgn0033095	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_001073497.1	Gene:	slc16a10 / 566499	ZFINID:	ZDB-GENE-040724-214	Length:	505	Species:	Danio rerio

Alignment Length:	780	Identity:	125/780 - (16%)
Similarity:	208/780 - (26%)	Gaps:	355/780 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 SSSTEKKTP---KMPDGGYGWVVVFASLVVSLIADGLSFSFGLINVELLEYFGESTS-----KTA 178
            :.::|:|:|   :.|:||:||||:.||:..:....|:..:||::.|.||..||....     |||
Zfish    51 TKASEQKSPEEFEPPEGGWGWVVMLASMWCNGSVFGIQNAFGIMFVYLLNEFGSEHDADLRFKTA 115

  Fly   179 WISSLFFSVPLLMGPIWSNLVDKYGCRKMTILGGVVSAFGFALSSFCNSIEMLMVTFGIISGLGL 243
            |:.||...:.....||.|...|..|||...:.|..|...|...|||..|:..:..|:||:...|.
Zfish   116 WVGSLSMGMIFFCSPIVSVFTDLLGCRITAVGGAAVGCVGLLASSFVTSLGPMYFTYGIVFACGC 180

  Fly   244 GIGYVTAVVSIAFWFDKKRTFATGIGASGTGIGTFVYARLTSYLIESYGWRGATLILGGTMLNAC 308
            ...|..::|.:..:|.::.....||..:|:.:.|.....:.|.|::|.|......:|...|.
Zfish   181 SFAYQPSLVILGHYFKRRLGLVNGIVTAGSSVFTITLPYMLSGLLKSVGLYHTLRVLAIFMF--- 242

  Fly   309 VCGALMRDPDWLIEENRLESRSQSVTTFSNSSVCLEEIKKLLDTGITKEAVLDSLVTKNNTEANQ 373
                                                   .|:..|:|.:
Zfish   243 ---------------------------------------ILMLAGLTYK---------------- 252

  Fly   374 QIDDPLDSALKRYRSEIFLPTFLSTQELDSICEVKSLSRRSLRHKEGEEAPSRENLLSMSSGAGA 438
                ||            ||..:|:.:..|.|
Zfish   253 ----PL------------LPKPVSSSKPGSRC--------------------------------- 268

  Fly   439 YPPSTAVIGSPDDTLMGGIAHEAAEEAKKAYLASIETLSPSEKRSTGRTPNGSLRSSDEGYLTQK 503
             ||
Zfish   269 -PP-------------------------------------------------------------- 270

  Fly   504 HASSRYSLNENIFMAKHTTPSISNLKVNGLRHNSVDILSEDMHCYYSKDETFALLEPSRRIRPTV 568

Zfish   271 ----------------------------------------------------------------- 270

  Fly   569 IAIPEQEQSVNSELATRRARLDSITGIRRLSRSKKPSHHRSNLRRNISIRNSNFLKDMRIHRNSI 633
                                         |||                |.|.|..|.:
Zfish   271 -----------------------------LSR----------------IFNVNIWKSL------- 283

  Fly   634 HYRGAMLNTHRYRLRASSCPNIYRNSMTTIAKEEEDTWYDNFVDTMKSIFDFSLFLDMKFALFNL 698
                      .||:.|...|                                       .||:.
Zfish   284 ----------GYRIWAFGIP---------------------------------------AALYG- 298

  Fly   699 STLFLFIWFIIPYLYLPDYMKQYKYDVSQSAELISDVGIAQTVGMIGLGYLGD-LSWMNINICYS 762
                    :.:||::|..::::.....:....|::.:||...||.:..|.:.| :..:|......
Zfish   299 --------YFVPYVHLMTHVEERFGPEANKEVLLACIGITSGVGRLIFGRVADYVPGVNKVFLQV 355

  Fly   763 LCMLVCGASVFFMPLLITNYMGLMVMCVIFGFTFASSFSFTPSILVSIVDLDDFTCAYGLVLLVQ 827
            ...:|.|.....:||... :.||:.:|::.|............|...:|...:.:.|.|.:|.:.
Zfish   356 SSFMVIGVMSMMIPLCHV-FGGLIAVCLLMGLFDGCFICIMAPIAFELVGSQNVSQAIGFLLGMM 419

  Fly   828 GVGMIAGPPIAGVIYEYTGRWDDTFYYAGIFIALSGVCSYLIEFCEKKAPKESDSDVLETKKAQL 892
            .:.|..||||||.:.:..|.:|..||.|||...:.|.....|.:.|.:..:...::..|..:..|
Zfish   420 SIPMTVGPPIAGFLRDRLGSYDVAFYLAGIPPLIGGAVLCAIPWVEARRKRREAANTAENTEKML 484

Fly 893 892
Zfish 485 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chk	NP_001163063.1	MFS	143..>315	CDD:119392	47/176 (27%)
chk	NP_001163063.1	MFS	<685..869	CDD:119392	41/184 (22%)
slc16a10	NP_001073497.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..64		3/12 (25%)
		2A0113	56..458	CDD:273325	120/747 (16%)
		MFS	71..462	CDD:119392	114/736 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	474..505		2/11 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810