DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment chk and slc16a12a

DIOPT Version :9

Sequence 1:	NP_001163063.1	Gene:	chk / 35578	FlyBaseID:	FBgn0033095	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	XP_009291327.1	Gene:	slc16a12a / 557762	ZFINID:	ZDB-GENE-080721-24	Length:	617	Species:	Danio rerio

Alignment Length:	765	Identity:	176/765 - (23%)
Similarity:	286/765 - (37%)	Gaps:	216/765 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 RRKRLISNESGDSIDSSSTEKKTPKMPDGGYGWVVVFASLVVSLIADGLSFSFGLINVELLEYFG 171
            :|.||...|....:.::         ||||:||::|....:.::....::....:..||...||.
Zfish    49 KRGRLEMGEKNPCLATA---------PDGGWGWMIVAGCFLTTVCTRAVTRCVSIFFVEFQLYFS 104

  Fly   172 ESTSKTAWISSLFFSVPLLMGPIWSNLVDKYGCRKMTILGGVVSAFGFALSSFCNSIEMLMVTFG 236
            ...|.||||.||.....:|..|:.|.:.::...|...::||::|:.|..|||...|:|.|.:|.|
Zfish   105 RDYSATAWIHSLLDCTTMLCAPLGSYIGNRLSSRIAIMIGGLLSSTGLLLSSLATSVEFLYLTLG 169

  Fly   237 IISGLGLGIGYVTAVVSIAFWFDKKRTFATGIGASGTGIGTFVYARLTSYLIESYGWRGATLILG 301
            :::|:|..:.|..|:..:..:|.:::..|.||..||:|||||:.|.....|||.:.||||.|||.
Zfish   170 VLTGVGFALSYTPAIAMVGSYFRQRKALAYGIAMSGSGIGTFILAPAVQLLIEFFSWRGALLILA 234

  Fly   302 GTMLNACVCGALMRDPDWLIEENRLESRSQSVTTFSNSSVCLEEIKKLLDTGITKEAVLDSLVTK 366
            |.:.:.||||||||.         |:|:..            .:.|..|:.|.|    :|.|..|
Zfish   235 GLVSHLCVCGALMRP---------LQSQRG------------RQNKMDLENGKT----VDLLNVK 274

  Fly   367 NNTEANQQIDDPLDSALKRYRSEIFLPTFLSTQELDSICEVKSLSRRSLRHKEGEEAPSRENLLS 431
                                         |:..||....||.....:.:..||    || ||:|.
Zfish   275 -----------------------------LAYVELRGSMEVTHAVVKEMEKKE----PS-ENMLR 305

  Fly   432 MSSGAGAYPPSTAVIGSPDDTLMGGIAHEAAEEAKKAYLASIETLSPSEKRSTGRTPNGSLRSSD 496
            ...|                       ...|::.|:::|             .|...:|.
Zfish   306 NGKG-----------------------WIEADDMKQSHL-------------DGEENHGQ----- 329

  Fly   497 EGYLTQKHASSRYSLNENIFMAKHTTPSISNLKVNGLRHNSVDILSEDMHCYYSKDETFALLEPS 561
                         .|:||        |...|                    .:|::|
Zfish   330 -------------DLSEN--------PKTVN--------------------KWSEEE-------- 345

  Fly   562 RRIRPTVIAIPEQEQSVNSELATRRARLDSITGIRRLSRSKKPSHHRSNLRRNISIRNSNFLKDM 626
                |..|:||...||                       |..|..:....::||:...|
Zfish   346 ----PRTISIPALVQS-----------------------SGLPLENLLKYQKNITFPES------ 377

  Fly   627 RIHRNSIHYRGAMLNTHRYRLRASSCPNIYRNSMTTIAKEEEDTWYDNFVDTMKSIFDFSLFLDM 691
            :...|:.....|.....:.:|...|..|::.....|:.||                  :|..|..
Zfish   378 KSEGNNNQSTVAKSKVVKAKLLKESKENVWSVLRKTVLKE------------------YSFLLIP 424

  Fly   692 KFALFNLSTLFLFIWFIIPYLYLPDYMKQYKYDVSQSAELISDVGIAQTVGMIGLGYLGDLSWMN 756
            .|.|..:|.|||.....:|::||..|.........|:|.::|.:|::..:|.|..|::.|...:.
Zfish   425 DFLLLLVSFLFLAYGCSVPFVYLVPYSLSAGVSPQQAALVMSILGVSGIIGTITFGWIADRKCLR 489

  Fly   757 IN--ICYSLCMLVCGASVFFMPLLITNYMGLMVMCVIFGFTFASSFSFTPSILVSIVDLDDFTCA 819
            ..  :.|.|.:...|.|..|:||| :.:..|:...:|:|:...:..:..|.:....|.....|.|
Zfish   490 PYRVVSYMLAVGSEGLSCLFLPLL-SGFSLLVPFSLIYGYFDGAYVALIPVVTSDTVSSAQLTSA 553

  Fly   820 YGLVLLVQGVGMIAGPPIAGVIYEYTGRWDDTFYYAGIFIALSGVCSYLI 869
            .|:|..:..:..:..|||.|.:.:.||.:..||..:|:    |.:||.:|
Zfish   554 LGVVYFLHAIPYLISPPIGGWLVDQTGSYTATFILSGV----SLICSAVI 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chk	NP_001163063.1	MFS	143..>315	CDD:119392	60/171 (35%)
chk	NP_001163063.1	MFS	<685..869	CDD:119392	49/185 (26%)
slc16a12a	XP_009291327.1	2A0113	55..601	CDD:273325	173/759 (23%)
slc16a12a	XP_009291327.1	MFS	75..604	CDD:119392	166/730 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	139	1.000	Domainoid score	I4741
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	1	1.000	-	-		otm25394
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X70
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.910