Protein Alignment chk and slc16a12b

DIOPT Version :9

• Sequence 1: NP_001163063.1
• Gene: chk / 35578
• FlyBaseID: FBgn0033095
• Length: 894
• Species: Drosophila melanogaster
• Sequence 2: NP_001139286.1
• Gene: slc16a12b / 449947
• ZFINID: ZDB-GENE-050522-80
• Length: 488
• Species: Danio rerio
• Alignment Length: 771
• Identity: 162/771 - (21%)
• Similarity: 244/771 - (31%)
• Gaps: 328/771 - (42%)

  Fly   121 DSSSTEKKTPKM--PDGGYGWVVVFASLVVSLIADGLSFSFGLINVELLEYFGESTSKTAWISSL 183
            |..:.|||...:  ||||:||::|....||::....::....:..||...:|.:..|.||||.||
Zfish    10 DYMAQEKKKGGVLPPDGGWGWMIVAGCFVVTVCTRAVTRCISIFFVEFQMHFAKDYSGTAWIHSL 74

  Fly   184 FFSVPLLMGPIWSNLVDKYGCRKMTILGGVVSAFGFALSSFCNSIEMLMVTFGIISGLGLGIGYV 248
            .....:|..|:.|.:.::..||...||||.:::.|..||||..|:|.|..|.|:::|||..:.|.
Zfish    75 VDCTTMLCAPLGSLIGNQLSCRIAVILGGFLASVGLVLSSFATSLEYLYATLGLLTGLGFALCYT 139

  Fly   249 TAVVSIAFWFDKKRTFATGIGASGTGIGTFVYARLTSYLIESYGWRGATLILGGTMLNACVCGAL 313
            .|:..:..:|.:::..|.||..||:|||||:.|.:...|||.|.||||.|||||.:||.||||||
Zfish   140 PAIAMVGIYFCERKALAYGIAMSGSGIGTFILAPVVQLLIEHYSWRGALLILGGFVLNLCVCGAL 204

  Fly   314 MRDPDWLIEENRLESRSQSVTTFSNSSVCLEEIKKLLDTGITKEAVLDSLVTKNNTEANQQIDDP 378
            :| |..|.||                ..|                                   |
Zfish   205 LR-PIILKEE----------------EAC-----------------------------------P 217

  Fly   379 LDSALKRYRSEIFLPTFLSTQELDSICEVKSLSRRSLRHKEGEEAPSRENLLSMSSGAGAYPPST 443
            |                    .:||.|                             |....||
Zfish   218 L--------------------PVDSEC-----------------------------GYSVKPP-- 231

  Fly   444 AVIGSPDDTLMGGIAHEAAEEAKKAYLASIETLSPSEKRSTGRTPNGSLRSSDEGYLTQKHASSR 508
                    ||.||....||.:||:
Zfish   232 --------TLNGGPTRSAASDAKQ----------------------------------------- 247

  Fly   509 YSLNENIFMAKHTTPSISNLKVNGLRHNSVDILSEDMHCYYSKDETFALLEPSRRIRPTVIAIPE 573
                                                 .|:.|..|...||.|
Zfish   248 -------------------------------------RCFQSMQEYHFLLMP------------- 262

  Fly   574 QEQSVNSELATRRARLDSITGIRRLSRSKKPSHHRSNLRRNISIRNSNFLKDMRIHRNSIHYRGA 638
                                                    :..:...:||
Zfish   263 ----------------------------------------DFLVLAGSFL--------------- 272

  Fly   639 MLNTHRYRLRASSCPNIYRNSMTTIAKEEEDTWYDNFVDTMKSIFDFSLFLDMKFALFNLSTLFL 703
                    |.||.|.
Zfish   273 --------LLASGCS-------------------------------------------------- 279

  Fly   704 FIWFIIPYLYLPDYMKQYKYDVSQSAELISDVGIAQTVGMIGLGYLGDLSWMN--INICYSLCML 766
                 :|::||..|..........:|.|:|.:|:...||.|..|:|.|...:.  .||||...:.
Zfish   280 -----LPFVYLVPYALDVGVGHQHAAFLMSILGVIDIVGNITFGWLTDRRCLKKYRNICYMFAVG 339

  Fly   767 VCGASVFFMPLLITNYMGLMVMCVIFGFTFASSFSFTPSILVSIVDLDDFTCAYGLVLLVQGVGM 831
            :.|....|:|||.| ::.|:...|::|:...:..:..|.:...:|.....:.|.|:|..:..|..
Zfish   340 MEGLCCLFIPLLRT-FVWLVPFSVLYGYFDGAYVALIPVVTSDVVGRQYLSSALGVVYFLHAVPY 403

  Fly   832 IAGPPIAGVIYEYTGRWDDTFYYAGIFIALSGVCSY---LIEFCEKKAPKESDSDV 884
            :..|||.|.:.:.||.:..||:.:|..:..|.:..:   :|.:|::...|.|.|.:
Zfish   404 LVSPPIGGWLVDTTGTYTATFFLSGFALISSSLLLFSVAIIRYCQRNQKKNSLSKI 459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
chk	NP_001163063.1	MFS	143..>315	CDD:119392	69/171 (40%)
		MFS	<685..869	CDD:119392	43/188 (23%)
slc16a12b	NP_001139286.1	MFS	33..430	CDD:119392	146/717 (20%)
		MFS_1	37..407	CDD:284993	136/690 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	139	1.000	Domainoid score	I4741
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	1	1.000	-	-		otm25394
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X70
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.810