DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chk and slc16a9b

DIOPT Version :9

Sequence 1:	NP_001163063.1	Gene:	chk / 35578	FlyBaseID:	FBgn0033095	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_001003552.1	Gene:	slc16a9b / 445158	ZFINID:	ZDB-GENE-040801-69	Length:	486	Species:	Danio rerio

Alignment Length:	780	Identity:	166/780 - (21%)
Similarity:	252/780 - (32%)	Gaps:	332/780 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 TPKMPDGGYGWVVVFASLVVSLIADGLSFSFGLINVELLEYFGESTSKTAWISSLFFSVPLLMGP 193
            |...||||:||.:|.||.:...:|.|...|.|::..|.|..|.:|...|||:.||...|.|:..|
Zfish     6 TKPAPDGGWGWAIVVASFMGQFLAYGSPQSVGVLYPEWLNTFQDSKGMTAWVGSLVSGVGLIASP 70

  Fly   194 IWSNLVDKYGCRKMTILGGVVSAFGFALSSFCNSIEMLMVTFGIISGLGLGIGYVTAVVSIAFWF 258
            |.|..|..:|.|.:||..||:.:.|..||:|..:::.|:.::||:.|||.|:.|...|.....:|
Zfish    71 ICSACVVNFGARPVTIFSGVMVSGGLMLSAFAPNVQFLIFSYGIVVGLGCGLVYAATVTITCQYF 135

  Fly   259 DKKRTFATGIGASGTGIGTFVYARLTSYLIESYGWRGATLILGGTMLNACVCGALMRD---PDWL 320
            ||:|..|.||..:||.:|.|:||...:..|..:|..|..|::|...||...|..|||.   |.:.
Zfish   136 DKRRGLALGIVTTGTSVGGFLYAAAQNEFIALFGLDGCLLLIGCFALNIIACAGLMRPLHLPAYY 200

  Fly   321 IEENRLESRSQSVTTFSNSSVCLEEIKK----LLDTGITKE----------AVLDSLVTKNNTEA 371
            :::....:..........|.|..:.:||    :|.||.||:          ..|..|:.|.
Zfish   201 LKQRAAMAEKAEENVLEKSPVVEDPVKKTQSIVLITGDTKDTHEKRKLLNYVTLVRLMKKK---- 261

  Fly   372 NQQIDDPLDSALKRYRSEIFLPTFLSTQELDSICEVKSLSRRSLRHKEGEEAPSRENLLSMSSGA 436
            .:|..:.|.|..:..::.:||.|.:|   |.:.|                              .
Zfish   262 QKQYSEYLHSIGQVLQNRVFLATCVS---LFAYC------------------------------L 293

  Fly   437 GAYPPSTAVIGSPDDTLMGGIAHEAAEEAKKAYLASIETLSPSEKRSTGRTPNGSLRSSDEGYLT 501
            |||.|                            |..:|.|:.||
Zfish   294 GAYTP----------------------------LLFLEDLAQSE--------------------- 309

  Fly   502 QKHASSRYSLNENIFMAKHTTPSISNLKVNGLRHNSVDILSEDMHCYYSKDETFALLEPSRRIRP 566
                                          ||
Zfish   310 ------------------------------GL--------------------------------- 311

  Fly   567 TVIAIPEQEQSVNSELATRRARLDSITGIRRLSRSKKPSHHRSNLRRNISIRNSNFLKDMRIHRN 631
                                     ||||
Zfish   312 -------------------------ITGI------------------------------------ 315

  Fly   632 SIHYRGAMLNTHRYRLRASSCPNIYRNSMTTIAKEEEDTWYDNFVDTMKSIFDFSLFLDMKFALF 696
                              |:.|
Zfish   316 ------------------STIP------------------------------------------- 319

  Fly   697 NLSTLFLFIWFIIPYLYLPDYMKQYKYDVSQSAELISDVGIAQTVGMIGLGYLGDLSWMNINICY 761
                                              |:|.:.||..||.:.||.:.|:.|||....|
Zfish   320 ----------------------------------LVSIMSIAAGVGKLLLGVMMDVRWMNSIYLY 350

  Fly   762 SLCMLVCGASVFFMPLLITNYMGLMVMCVIFGFTFASSFSFTPSILVSIVDLDDFTCAYGLVLLV 826
            ::.:|..|.::..:| :..||.||.|:..:.|| |:.::|..|.:...:|.:|..|.|||:::..
Zfish   351 AVTLLGTGMALLIIP-VTKNYAGLQVISAVLGF-FSGNWSVIPYMTTKVVGMDRLTEAYGILMFF 413

  Fly   827 QGVGMIAGPPIAGVIYEYTGRWDDTFYYAGIFIALSGVCSYLIEF-C------EKKAP-KESDSD 883
            .|..::.|||:||.||::...:|..||::|.|:.|.|...:|... |      |.|.| ||..:|
Zfish   414 GGFSIMLGPPVAGWIYDWMHSYDLAFYFSGGFVLLGGAGLFLSALSCWNKNQEETKTPDKEYTND 478

Fly 884 883
Zfish 479 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chk	NP_001163063.1	MFS	143..>315	CDD:119392	62/171 (36%)
chk	NP_001163063.1	MFS	<685..869	CDD:119392	47/183 (26%)
slc16a9b	NP_001003552.1	2A0113	8..474	CDD:273325	162/772 (21%)
slc16a9b	NP_001003552.1	MFS	19..455	CDD:119392	151/742 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910