DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chk and CG13907

DIOPT Version :9

Sequence 1:	NP_001163063.1	Gene:	chk / 35578	FlyBaseID:	FBgn0033095	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_001286894.1	Gene:	CG13907 / 38104	FlyBaseID:	FBgn0035173	Length:	816	Species:	Drosophila melanogaster

Alignment Length:	881	Identity:	238/881 - (27%)
Similarity:	376/881 - (42%)	Gaps:	197/881 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 GAGHSRVVRSSVIELEDGTMTCLMNGNGQVKRRKRLISNES----------GDSIDSSSTEKKTP 130
            |...:...|....|..|..:.|        :...||.:.:|          .|..|..|...:.|
  Fly    13 GGNSASSARLRRFERTDSELAC--------EEAARLTAEQSPEDEDNQDNDEDDDDEESVYGELP 69

  Fly   131 KMPDGGYGWVVVFASLVVSLIADGLSFSFGLINVELLEYFGESTSKTAWISSLFFSVPLLMGPIW 195
            ..||||||||:.|||.:.::|.||::::||:...|.:.||.|.....||:.||...|.|..|||.
  Fly    70 PPPDGGYGWVICFASFMCNMIVDGIAYTFGIFLEEFVAYFHEGKGTVAWVGSLLSGVYLSAGPIV 134

  Fly   196 SNLVDKYGCRKMTILGGVVSAFGFALSSFCNSIEMLMVTFGIISGLGLGIGYVTAVVSIAFWFDK 260
            |.|.:|||||.:.|.|.:::...|.||:|..::.|||.|:|.:.|.|.|:.|:.|||::.::|:.
  Fly   135 SALANKYGCRAVCIAGSIIACIAFVLSTFSTNVSMLMATYGFMGGFGFGMIYLPAVVAVGYYFET 199

  Fly   261 KRTFATGIGASGTGIGTFVYARLTSYLIESYGWRGATLILGGTMLNACVCGALMRDPDW------ 319
            ||:.||||...|:|.|||.:|.|.:||:|.|||:.|.||..|.:||..:.||:||...:
  Fly   200 KRSLATGIAVCGSGFGTFAFAPLATYLLEEYGWKNALLIFAGLILNCAIFGAMMRPLTYPKKKKQ 264

  Fly   320 ------LIEENRLESRSQSVTTFSNSSVCLE--------EIKKLL--DTGITKEAVLDSLVTKNN 368
                  :.||.:|:....|   |:.|...::        ::|..|  |.|:.....|:.|.
  Fly   265 KPLMQRMYEEKQLQLERGS---FAGSHFMVQLPDGTIERKLKMPLNADPGVHSSLNLELLA---- 322

  Fly   369 TEANQQID----DPLDSALKRYRSEIFLPTFLSTQELDSICEVKSLSRRSLRHKEGEEAP---SR 426
                ||..    .|:.:          |||...::.:|            :..:.|.::|   ..
  Fly   323 ----QQAGGGGLHPVST----------LPTITESKVVD------------VHRQNGAQSPPNGDS 361

  Fly   427 ENLLSMSSGAGAYPPSTAVIGSPDDTLMGGIAHEAAEEAKKAYLASIETLSPSEKRSTGRTPNGS 491
            ...||..|.|||                                             .||.|:.:
  Fly   362 NGQLSARSAAGA---------------------------------------------VGRRPHRN 381

  Fly   492 LRSSDEGYLTQKHASSRYSLNENIFMAKHTTPSISNLKVNGLRHNSVDILSEDMHCYYSKDETFA 556
            ..|.:..|.:| .|.:|.:.........|     .:|..||    ||...:..:.      :|.|
  Fly   382 SESENSPYHSQ-DAMTRNASQPAFLAGDH-----QSLPKNG----SVPAFNTRVR------KTSA 430

  Fly   557 LLEPSRRIRPTVIAIPEQEQSVNSELATRRARLDSITG----IRRLSRSKKPSHHRSNLRRNISI 617
                |.|.:|::.||          .||.|..|::..|    ..:||.|::....::.
  Fly   431 ----SERFQPSLAAI----------RATSRGDLEAGAGGDFASSKLSLSQRQGGSQTG------- 474

  Fly   618 RNSNFLKDMRIHRNSIHYRGAMLNTHRYRLRASSCPNIYRNSMTTIAKEEEDTW----------- 671
            .:...::.|  .|..|.|.|::.|..:|:.:.|...  ||||:.::.|.|:...
  Fly   475 SSGRMVRPM--SRKDIFYSGSVTNLPQYQSQKSLAN--YRNSVLSLTKYEKSMQSVAKLDPLAEA 535

  Fly   672 ------YD-----NFVDTMKSI----FDFSLFLDMKFALFNLSTLFLFIWFIIPYLYLPDYMKQY 721
                  ||     ...|::||:    .|.||..|..|.|..:|.:|......:|::||.|..|::
  Fly   536 EKHREEYDLCPCLGIPDSVKSVVNTMLDVSLLKDPVFMLIGVSNIFGMAGLYVPFVYLVDAAKEH 600

  Fly   722 KYDVSQSAELISDVGIAQTVGMIGLGYLGDLSWMNINICYSLCMLVCGASVFFMPLLITNYMGLM 786
            ....:.:|.|:|.:||..|||.:..|::.||..:|..:..:.|:||...:|...||.. :|...:
  Fly   601 DIPKNDAAMLLSIIGITNTVGRVFCGWVADLPQVNSLLLNNCCLLVSTIAVTLTPLCY-SYAAYI 664

  Fly   787 VMCVIFGFTFASSFSFTPSILVSIVDLDDFTCAYGLVLLVQGVGMIAGPPIAGVIYEYTGRWDDT 851
            .|.:.||...:...|.|..|||.::.||..|.|:||::|.:|...:.|.|:||.||:.|..:|..
  Fly   665 TMSIFFGLAISGYISLTSIILVDLLGLDKLTNAFGLLILFRGFAALIGTPLAGAIYDMTHTYDLP 729

  Fly   852 FYYAGIFIALSGVCSYLIEFCEKKAPKESDSDVLET 887
            ||.||....:|.:.|:|....::.:|.|.....:||
  Fly   730 FYMAGALFGISTITSFLAPCLKRCSPSEETPVHVET 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chk	NP_001163063.1	MFS	143..>315	CDD:119392	74/171 (43%)
chk	NP_001163063.1	MFS	<685..869	CDD:119392	61/183 (33%)
CG13907	NP_001286894.1	MFS	78..>258	CDD:119392	78/179 (44%)
CG13907	NP_001286894.1	MFS	<570..748	CDD:119392	59/178 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I4618
eggNOG	1	0.900	-	-		E1_KOG2504
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	290	1.000	Inparanoid score	I2778
Isobase	1	0.950	-	0.919607	Normalized mean entropy	S5541
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	1	1.000	-	-		mtm8713
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11360
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4139
SonicParanoid	1	1.000	-	-		X70
	10	9.940