DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chk and Sln

DIOPT Version :9

Sequence 1:	NP_001163063.1	Gene:	chk / 35578	FlyBaseID:	FBgn0033095	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_610706.1	Gene:	Sln / 36263	FlyBaseID:	FBgn0033657	Length:	855	Species:	Drosophila melanogaster

Alignment Length:	811	Identity:	202/811 - (24%)
Similarity:	335/811 - (41%)	Gaps:	184/811 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 GAG----HSRVVRSSVIELEDGTMTCLMNGNGQVKRRKRLISNESGDSIDSSSTEKKTPKM--PD 134
            |:|    .||.||.:. |.|...:|        |.||.:.:..:...|  :::||...|.:  ||
  Fly   174 GSGLNTARSRCVRRAK-ERERDRVT--------VARRSKQVVKDRDSS--TTTTESGGPNVEPPD 227

  Fly   135 GGYGWVVVFASLVVSLIADGLSFSFGLINVELLEYFGESTSKTA-WISSLFFSVPLLMGPIWSNL 198
            |||||.:||.:..|.....||..|:|::.||::|.|..||:..| ||.::..::.|::.|:.|.|
  Fly   228 GGYGWFIVFGAFSVQFWVAGLVKSYGVLYVEIMETFPSSTATVASWIPAILSALCLVLAPLSSAL 292

  Fly   199 VDKYGCRKMTILGGVVSAFGFALSSFCNSIEMLMVTFGIISGLGLGIGYVTAVVSIAFWFDKKRT 263
            ..::.||.:..:||:..|.|..||.|..|:..|::|||:::|:|.|:.....:|.::.:|||.|.
  Fly   293 CQRFSCRTVVFVGGIFCAMGMILSYFATSLLHLLLTFGVLTGIGGGLSTTPGIVIVSQYFDKHRA 357

  Fly   264 FATGIGASGTGIGTFVYARLTSYLIESYGWRGATLILGGTMLNACVCGALMRDPDWLIEENRLES 328
            .|.||..|||..|:|:...|..:|.|:.|:.|..|||||.||:.||...|.|
  Fly   358 LANGICVSGTAAGSFILPVLIKHLAENCGFHGTILILGGCMLHVCVSATLYR------------- 409

  Fly   329 RSQSVTTFSNSSVCLEEIKKLLDTGITKEAVLDSLVTKNNTEANQQIDDPLDSALKRYRSEIFLP 393
               .::.:::.           |:|..:|.....|    |.:.|......|.::
  Fly   410 ---PISAYTDQ-----------DSGQGQEETAKPL----NEDINPSTTGILTTS----------- 445

  Fly   394 TFLSTQELDSICEV---KSLSRRSLRHKEGEEAPSRENLLSMSSGAGAYPPSTAVIGSPDDTLMG 455
            |:|.|      |:|   ..||.:.:.|...||:.:..|
  Fly   446 TYLDT------CDVGAGHELSDKFIEHLFLEESKNHLN--------------------------- 477

  Fly   456 GIAHEAAEEAKKAYLASIETLSPSEKRSTGRTPNGSLRSSDEGYLTQKHASSRYSLNENIFMAKH 520
                         |.||.:   |::.:|       :..|.||         .:..:.|..|:
  Fly   478 -------------YYASKQ---PAQDKS-------AQESDDE---------VKDIIGETTFI--- 507

  Fly   521 TTPSISNLKVNGLRHNSVDILSEDMHCYYSKDETFALLEPSRRIRPTVIAIPEQEQSVNSELATR 585
              ..:..::.:||.| ||:.||.|....|.|.........||| |..|.|..|....:.:.|
  Fly   508 --KPMKKVRSSGLLH-SVEDLSTDSTWVYRKHSGTDSNRGSRR-RRNVFANDEVISKIQAHL--- 565

  Fly   586 RARLDSITGIRRLSRSKKPSHHRSNLRRNIS--------IRNSNFLKDMRIHRNSIHYRGAMLNT 642
                            :||....|.:.|.:|        :.|.:.||...:.:..:....:.|
  Fly   566 ----------------EKPLSPPSVVSRGLSKSMEIPTPVSNLSDLKQQPVEQAELGILDSQL-- 612

  Fly   643 HRYRLRASSCPNIYRNSMTTIAKEEEDTWYD----NFVDTMKSIFDFSLFLDMKFALFNLSTLFL 703
                     ..:|........|.|::|...:    ...:.::...|.||..|..|.|..||...:
  Fly   613 ---------VESIIDGDGHLAADEDDDDDEERGPRTCCERIEMYLDISLLQDPSFILMCLSVTLM 668

  Fly   704 FIWFIIPYL--YLPDYMKQYKYDVSQSAELISDVGIAQTVGMIGLGYLGDLSWMNINICYSLCML 766
            .:.  .||:  |||.::....|:.|::..|::...:...:|.:|||:|.||...:....|:||:|
  Fly   669 SVG--CPYMLYYLPAHVISIGYNKSEAGYLVAISAVLDLIGRLGLGWLCDLQLFDRKKTYTLCIL 731

  Fly   767 VCGASVFFMPLLITNYM-GLMVMCVIFGFTFASSFSFTPSILVSIVDLDDFTCAYGLVLLVQGVG 830
            ..|.:|..:|...|..: ||  ...::|....|.:...|.:|..:...|..:.:||||.:.|.:|
  Fly   732 GAGCAVLTIPFAKTLVLVGL--SAAVYGLCLGSWYVLMPVLLADVFGTDRISSSYGLVRMFQSIG 794

  Fly   831 MIAGPPIAGVIYEYTGRWDDTFYYAGIFIAL 861
            .|:.||:||::.:.:|.::..||..|..:.|
  Fly   795 AISVPPLAGLMRDLSGDYEICFYCMGSCMVL 825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chk	NP_001163063.1	MFS	143..>315	CDD:119392	64/172 (37%)
chk	NP_001163063.1	MFS	<685..869	CDD:119392	53/180 (29%)
Sln	NP_610706.1	MFS	235..>411	CDD:119392	66/191 (35%)
		MFS	<656..827	CDD:119392	50/174 (29%)
		MFS_1	658..>847	CDD:284993	50/172 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I4618
eggNOG	1	0.900	-	-		E1_KOG2504
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	117	1.000	Inparanoid score	I274
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	1	1.000	-	-		mtm13433
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11360
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X70
	8	7.960