DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chk and out

DIOPT Version :9

Sequence 1:	NP_001163063.1	Gene:	chk / 35578	FlyBaseID:	FBgn0033095	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_001285435.1	Gene:	out / 32926	FlyBaseID:	FBgn0259834	Length:	655	Species:	Drosophila melanogaster

Alignment Length:	783	Identity:	152/783 - (19%)
Similarity:	280/783 - (35%)	Gaps:	213/783 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 KRLISNESGDSIDSSSTEKKTPK------------MPDGGYGWVVVFASLVVSLIADGLSFSFGL 161
            |..::.::...:.:.:|:.|.||            .||||:||||..|:.:.:.........:||
  Fly     3 KSSLTEKNHTQVYNDTTKPKKPKRRDKSDLGPDFVAPDGGWGWVVCLAAGLNNFFLFPALQQYGL 67

  Fly   162 INVELLEYFGESTSKTAWISSLFFSVPLLMGPIWSNLVDKYGCRKMTILGGVVSAFGFALSSFCN 226
            |....::..|....:|..|.::..::..|:|.:...:..::..|::.:.|..::..|..||:||.
  Fly    68 IYRVRMQSLGFDAKQTTTIVNVVMAISSLVGIVNGAMFRRFTFRQVALTGTSLAFLGVFLSAFCT 132

  Fly   227 SIEMLMVTFGIISGLGLGIGYVTAVVSIAFWFDKKRTFATGIGASGTGIGTFVYARLTSYLIESY 291
            :....::....|.|:|||:......:::..:|..||..|||...:.||:|...:.::::.|:..|
  Fly   133 TFWQYIICLSAIFGIGLGLAMAATSLAVNTYFKLKRRRATGFSWTITGLGPIFFPQVSTVLLGYY 197

  Fly   292 GWRGATLILGGTMLNACVCGALMRDPDWLIEE------NRLESRSQSVTTFSNSSVCLEEIKKLL 350
            |.:|..||..|..:||.:|...::...|.:::      |.:|.              :.|.:||
  Fly   198 GAQGTILIYAGIAMNAILCALTLQPVLWHVKKPEKPVHNTIEG--------------IAETEKL- 247

  Fly   351 DTGITKEAVLDSLVTKNNTEANQQIDDPLDSALKRYRSEIFLPTFLSTQELDSICEVKSLSRRSL 415
                 :..:|         |||..:..|.:...|.|..:              .|:.:..|:|.|
  Fly   248 -----QPELL---------EANGNLLSPSNDPWKDYECK--------------YCQYQKRSKRGL 284

  Fly   416 ---RHKEGEEAPSRENLLSMSSGAGAYPPSTAVIGSPDDTLMGGIAHEAAEEAKKAYLASIETLS 477
               ::....:.|.|       .|.....|.|.::...:|...|
  Fly   285 FSSQYLFNVDDPER-------PGYEITEPGTPMLARANDGWFG---------------------- 320

  Fly   478 PSEKRSTGRTPNGSLRSSDEGYLTQKHASSRYSLNENIFMAKH----TTPSISNLKVNGLRHNSV 538
             |:...|..:..|:...:.:..:.|..:.||.:| :.:...:|    .|||.:.|    .:.|..
  Fly   321 -SKLSLTSESAGGARSRTRQALMRQVSSRSRENL-DRLEQNRHDQGPDTPSAAAL----YKPNYF 379

  Fly   539 DILSEDMHCYYSKDETFALLEPSRRIRPTVIAIPEQEQSVNSELATRRARLDSITGIRRLSRSKK 603
            :...||:..|.||...:     ||         |.|::.:....|..:|.|....
  Fly   380 NREREDLDRYASKTSVY-----SR---------PGQDELLRCTCAEDKALLQKTA---------- 420

  Fly   604 PSHHRSNLRRNISIRNSNFLKDMRIHRNSIHYRGAMLNTHRYRLRASSCPNIYRNSMTTIAKEEE 668
                                :.:::                         |::.||......|||
  Fly   421 --------------------ESLQV-------------------------NLFNNSADNTEAEEE 440

  Fly   669 DTWYDNFVDTMKSIFDFSLFLD------------MKFALFNLSTLFLFIWFIIPYLYLPDYMKQY 721
            ......|...:...||..|..|            |.|...|.|.|..||            :..:
  Fly   441 AKRRMTFFQKVSKFFDLDLLRDFTFVNLAVGMSIMMFGEMNFSVLTPFI------------LNSF 493

  Fly   722 KYDVSQSAELISDVGIAQTVGMIGLGYLGDLSWMNI----NICYS---LCMLVCGASVFFMPLLI 779
            .|..:|.:.::|.:....    |.:.:|..|:...:    .:.::   ||:.|....|.|
  Fly   494 GYTDTQISLVMSLLACMD----ISVRFLAPLALEKVKLDNRVLFAFGILCIAVGRVVVAF----- 549

  Fly   780 TNYMGLMV-MCVIFGFTFASSFSFTPSILVSIVDLDDFTCAYGLVLLVQGVGMIAGPPIAGVIYE 843
            |:...:|: :.::.||..|....|:|.|:.|.|.|:....|.||.|:...:...|..||.|::.|
  Fly   550 TDSYEIMIGVFLLIGFGKAFRTIFSPLIIPSYVPLNRLPAASGLQLIFNTIFSFAMGPILGILTE 614

  Fly   844 YTG 846
            ..|
  Fly   615 AYG 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chk	NP_001163063.1	MFS	143..>315	CDD:119392	40/171 (23%)
chk	NP_001163063.1	MFS	<685..869	CDD:119392	41/182 (23%)
out	NP_001285435.1	MFS	45..>225	CDD:119392	43/179 (24%)
		MFS	<464..621	CDD:119392	39/175 (22%)
		MFS_1	468..>621	CDD:284993	39/171 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11360
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X70
	4	3.910