DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chk and CG8034

DIOPT Version :9

Sequence 1:	NP_001163063.1	Gene:	chk / 35578	FlyBaseID:	FBgn0033095	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_573376.2	Gene:	CG8034 / 32924	FlyBaseID:	FBgn0031011	Length:	647	Species:	Drosophila melanogaster

Alignment Length:	804	Identity:	167/804 - (20%)
Similarity:	294/804 - (36%)	Gaps:	220/804 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 KTPK--MPDGGYGWVVVFASLVVSLIADGLSFSFGLINVELLEYFGESTSKTAWISS-----LFF 185
            |.|:  .||||:|||..|...:|:|....:..||||:..:.|:.....|:..|.|.|     :.|
  Fly     4 KQPRKVAPDGGWGWVACFGVSLVNLATRSIEPSFGLLFGDTLKELNVGTTGAAVIISALDVCMNF 68

  Fly   186 SVPLLMGPIWSNLVDKYGCRKMTILGGVVSAFGFALSSFCNSIEMLMVTFGIISGLGLGIGYVTA 250
            | .|.:||    |:.::..||:.|.|.::...|.||:|...|:..::.|:.:|:|:|:|:....|
  Fly    69 S-GLFVGP----LLKEFSYRKVAIAGSLLCGLGLALTSPATSMAHILSTYSVINGIGVGLSTSAA 128

  Fly   251 VVSIAFWFDKKRTFATGIGASGTGIGTFVYARLTSYLIESYGWRGATLILGGTMLNACVCGALMR 315
            .|::..:|..||..|.|:..:||.:|..:..:|...|:|:|.:|||.|:|.|..|||.|...|::
  Fly   129 FVALNHYFKHKRGQAVGLSMAGTAMGMLIMPQLVRILLEAYDFRGAVLLLAGVALNATVGSVLLQ 193

  Fly   316 DPDWLIEENRLESRSQSVTTFSNSS-VCLEEIKKLLDTGITKEAVLDSLVTKNNTEANQQIDDPL 379
            ...|.::|.           |.:.. :|:..:.       |.:..|    |............|:
  Fly   194 PVKWHMKEE-----------FDDEELMCISALP-------TPQPQL----TVGGAGGAASAGAPV 236

  Fly   380 DSALKRYRSEIFLPTFLSTQELDSICEVKSL-------SRRSLRHKEGEEA-----------PSR 426
            ...:|.           ...|.|::.|:.:|       .:.|:|....|.|           |.|
  Fly   237 FKVIKE-----------DGNEEDALPEMNTLLFHKPHPHQHSMRKNYSEMAMNTMNGSRLGIPKR 290

  Fly   427 ENLLSMSSGAGAYPPSTAVIGSPDDTLMGGIAHEAAEEAK--KAYLASIETLSPSEKRSTGRTPN 489
            .....:.|.||.   .:|..|:..|:  ||...:|...|.  :...||: |.:.|....||....
  Fly   291 PTFPRIMSLAGV---QSAAHGAGGDS--GGYTSQAEVNATQLRCRKASV-TSNLSYMDFTGSILQ 349

  Fly   490 GSLRSSDEGYLTQKHASSRYSLNENIFMAKHTTPSISNLKVNGLRHNSVDILSEDMHCYYSKDET 554
            ..|.:.|:.:            .:|....:....:..::.:.|.|.:.:
  Fly   350 VHLNTGDDEF------------EQNDRELRRVGTATGSIVLGGHRDSFI---------------- 386

  Fly   555 FALLEPSRRIRPTVIAIPEQEQSVNSELATRRARLDSITGIRRLSRSKKPSHHRSNLRRNISIRN 619
                    :::||       |....:|.|   |.||.    ....::|||..    .||...:.:
  Fly   387 --------KMKPT-------ELDKQAEAA---AALDE----EAKKKAKKPGF----WRRFADLLD 425

  Fly   620 SNFLKDMRIHRNSIHYRGAMLNTHRYRLRASSCPNIYRNSMTTIAKEEEDTWYDNFVDTMKSIFD 684
            .:.|||
  Fly   426 IDMLKD----------------------------------------------------------- 431

  Fly   685 FSLFLDMKFALFNLSTLFLFIWFIIPY---LYLPDYMKQYKYDVSQSAELISDVGIAQTVGMIGL 746
             .:||::   ||.||     |:::...   :..|.:.....|..:..|..:|...|......|.|
  Fly   432 -KMFLNL---LFGLS-----IFYVAEMNFKMVTPFFFANLGYQKTDVAFCLSITAITDIAARIVL 487

  Fly   747 GYLGDLSWMNINICYSLCMLVCGASVFFMPLL------ITNYMGLMVMCVIFGF---TFASSFSF 802
            ..:.|.:.:.....:.:       |:.|:.|.      .|.:..||:...|.||   :..|:|:.
  Fly   488 PPIFDRTTIKKRTIFLV-------SIIFVALTRSIMAEQTEWTQLMIWLSICGFFRGSALSNFTL 545

  Fly   803 TPSILVSIVDLDDFTCAYGLVLLVQGVGMIAGPPIAGVIYEYTGRWDDTFYYAGIFIALSGVC-- 865
            |.|...|   |:....|:|..|:.:.:.:|...|:.|:|.:.|..:....:...:.|.:....
  Fly   546 TVSEYCS---LEKLPSAFGWHLVGKALFVITFGPLIGLIRDVTDSYPICIHTQSVCIMICATAWG 607

  Fly   866 -SYLIEFCEKKAPKESDSDVLETK 888
             .||:|:.:.:. :.:|:..|.|:
  Fly   608 IEYLVEYIQSRR-RTADAAQLPTQ 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chk	NP_001163063.1	MFS	143..>315	CDD:119392	57/176 (32%)
chk	NP_001163063.1	MFS	<685..869	CDD:119392	40/198 (20%)
CG8034	NP_573376.2	MFS	20..>197	CDD:119392	57/181 (31%)
		MFS	<437..583	CDD:119392	35/163 (21%)
		MFS_1	437..>581	CDD:284993	34/161 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	64	1.000	Domainoid score	I559
eggNOG	1	0.900	-	-		E1_KOG2504
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm13433
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11360
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.910