DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chk and Mct1

DIOPT Version :9

Sequence 1:	NP_001163063.1	Gene:	chk / 35578	FlyBaseID:	FBgn0033095	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_001284810.1	Gene:	Mct1 / 31198	FlyBaseID:	FBgn0023549	Length:	626	Species:	Drosophila melanogaster

Alignment Length:	788	Identity:	235/788 - (29%)
Similarity:	353/788 - (44%)	Gaps:	183/788 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 NGQVKRRKRLISNESGDSIDSSSTEKKTPKMPDGGYGWVVVFASLVVSLIADGLSFSFGLINVEL 166
            :|...|||   |.:..::.:.....:.||  ||||:||||||.|.::.::.||:::|||:...|.
  Fly     3 HGPPARRK---SQQQHEACEMDMERQPTP--PDGGWGWVVVFGSFMIHIVTDGMTYSFGIFYNEF 62

  Fly   167 LEYFGESTSKTAWISSLFFSVPLLMGPIWSNLVDKYGCRKMTILGGVVSAFGFALSSFCNSIEML 231
            |:||.|....||||:|:...|....|||.|:.|::||||.:||.|.:::|....:|.|..::..|
  Fly    63 LDYFNEGKGYTAWIASIMVGVTFSSGPISSSFVNRYGCRAVTIAGSILAASCIIVSMFAQNVLTL 127

  Fly   232 MVTFGIISGLGLGIGYVTAVVSIAFWFDKKRTFATGIGASGTGIGTFVYARLTSYLIESYGWRGA 296
            ::|.|..:|||.|:.|:.|:||:..:|:.||:.||||...|:|.||||:|.||.:||.:||||||
  Fly   128 IITIGFGTGLGFGLIYLPAIVSVTQYFEAKRSLATGIAVCGSGFGTFVFAPLTEFLIGNYGWRGA 192

  Fly   297 TLILGGTMLNACVCGALMRDPDWLIEENRLESRSQSVTTFSNSSVCLEEIKKLLDTGITKEAVLD 361
            .||:||.:||..:.||:.|.         ||..:...|..:..|.     .||    ..|.|::|
  Fly   193 MLIIGGIVLNCIIFGAMFRP---------LELEAPPQTPPNTPST-----PKL----AKKSAIID 239

  Fly   362 SLVTKNNTEANQQIDDPLDSALKRYRSEIFLPTFLSTQELDSICEVKSLSR-RSLRHKEGEEAPS 425
            ...|....|..:.:  |.|..|:       ||     |..|:.....:|.| .|:.|.      .
  Fly   240 QNTTAAELEPLKVL--PKDQYLQ-------LP-----QRTDTAVSGGALCRSNSVGHN------L 284

  Fly   426 RENLLSMSSGAG-------AYPPSTAVIGSPDDTLMGGIAHEAAEEAKKAYLASIETLSPSEKRS 483
            :.||.:.|:||.       ..||...|..:.:|.:           |:|.:  |...|:|.....
  Fly   285 KPNLNNNSNGAVNGQGPTLVTPPQAVVKSTSNDDI-----------ARKCH--SQLQLTPLRDAH 336

  Fly   484 TGRTPNGSLRSSDEGYLTQKHASSRYSLNENIFMAKHTTPSISNLKVNGLRHNSVDILSEDMHCY 548
            ..|:.:|::...|..|                               .|..||..|.:|
  Fly   337 RERSASGTMYRPDALY-------------------------------QGSLHNLPDYVS------ 364

  Fly   549 YSKDETFALLEPSRRIRPTVIAIPEQEQSVNSELATRRARLDSITGIRRLSRSKKPSHHRSNLRR 613
                                                  :|.|       ||||...|   ..::|
  Fly   365 --------------------------------------SRND-------LSRSMSGS---GVIKR 381

  Fly   614 NISIRNSNFLKDMRIHRNSIHYRGAMLNTHRYRLRASSCPNIYRNSMTTIAKEEEDTWYDNFVDT 678
            ..|:|.||                   |..:.:..|..|..|      |.:||..||    |.:.
  Fly   382 YGSLRQSN-------------------NVSQSQEEAKCCGCI------TCSKETRDT----FAEM 417

  Fly   679 MKSIFDFSLFLDMKFALFNLSTLFLFIWFIIPYLYLPDYMKQYKYDVSQSAELISDVGIAQTVGM 743
            |    :|||..||.|.:|::|.....|.|.:||||:..|.:..|...:.::.|||.:|:|.|||.
  Fly   418 M----NFSLLKDMVFVIFSVSNFCTSIGFNVPYLYVVAYAETLKLTKTDASYLISTIGVANTVGR 478

  Fly   744 IGLGYLGDLSWMNINICYSLCMLVCGASVFFMPLLITNYMGLMVMCVIFGFTFASSFSFTPSILV 808
            |.|||:.|..|:|..:.|::|:..||.|...:| |..::..|...|.:||||..:....|..|||
  Fly   479 IILGYISDKPWVNRLLVYNVCLTACGVSTAMVP-LCHDFQSLAFYCCVFGFTIGAYVGLTSVILV 542

  Fly   809 SIVDLDDFTCAYGLVLLVQGVGMIAGPPIAGVIYEYTGRWDDTFYYAGIFIALSGVCSYLIEFCE 873
            .::.||..|.|:||:||.||:....||||.|.:|:.|..:...|..||:.||:||:..:.|...:
  Fly   543 DLLGLDKLTNAFGLLLLFQGIASFIGPPIGGWMYDLTDSYAPAFLMAGLMIAISGLVMFAIPPLQ 607

  Fly   874 KKAPKESD 881
            :...::|:
  Fly   608 RLQVRKSE 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chk	NP_001163063.1	MFS	143..>315	CDD:119392	76/171 (44%)
chk	NP_001163063.1	MFS	<685..869	CDD:119392	72/183 (39%)
Mct1	NP_001284810.1	MFS	35..>213	CDD:119392	81/186 (44%)
Mct1	NP_001284810.1	MFS	<426..604	CDD:119392	68/178 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I4618
eggNOG	1	0.900	-	-		E1_KOG2504
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	290	1.000	Inparanoid score	I2778
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	1	1.000	-	-		otm25394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11360
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X70
	8	7.960