Protein Alignment chk and Slc16a4

DIOPT Version :10

• Sequence 1: NP_610230.3
• Gene: chk / 35578
• FlyBaseID: FBgn0033095
• Length: 894
• Species: Drosophila melanogaster
• Sequence 2: NP_001013935.1
• Gene: Slc16a4 / 295356
• RGDID: 1359655
• Length: 500
• Species: Rattus norvegicus
• Alignment Length: 765
• Identity: 158/765 - (20%)
• Similarity: 258/765 - (33%)
• Gaps: 286/765 - (37%)

  Fly   126 EKKTP--KMPDGGYGWVVVFASLVVSLIADGLSFSFGLINVELLEYFGESTSKTAWISSLFFSVP 188
            ||.:|  |..|||:||:||....:|::...|::.:|.:..|...|.|..::.:..||.|:..|:.
  Rat     6 EKPSPYTKPLDGGWGWMVVLHFFLVNVFVMGMTKTFAIFFVVFQEEFEGTSEQIGWIGSIMSSLR 70

  Fly   189 LLMGPIWSNLVDKYGCRKMTILGGVVSAFGFALSSFCNSIEMLMVTFGIISGLGLGIGYVTAVVS 253
            ...||:.:.:.|.:|.:..:|||..:.:.|:.:||:...|..|.||.|::.|||....|..|.|.
  Rat    71 FSAGPLAAIICDIFGEKTTSILGTFLVSGGYLISSWATGIPFLCVTMGLLPGLGSAFLYQVAAVV 135

  Fly   254 IAFWFDKKRTFATGIGASGTGIGTFVYARLTSYLIESYGWRGATLILGGTMLNACVCGALMRDPD 318
            |..:|.|:...:|.|..||.|: ||:.|..|..||:.|.|.||.::.|...||......|:|..
  Rat   136 ITKYFKKRLGLSTAIARSGMGL-TFLLAPFTKLLIDLYDWTGALILFGAIALNLVPSSMLLRPV- 198

  Fly   319 WLIEENRLESRSQSVTTFSNSSVCLEEIKKLLDTGITKEAVLDSLVTKNNTEANQQIDDPLDSAL 383
                  .::|.|.|            :||       .|.::|
  Rat   199 ------HIQSDSNS------------DIK-------NKGSIL----------------------- 215

  Fly   384 KRYRSEIFLPTFLSTQELDSICEVKSLSRRSLRHKEGEEAPSR----ENLLSMSSGAGAYPPSTA 444
                                     |.:...|.||  .|.|:|    |:|:..|:...:..|:|
  Rat   216 -------------------------SATGPELSHK--TETPNRNKAQESLIKDSAVKKSGQPTT- 252

  Fly   445 VIGSPDDTLMGGIAHEAAEEAKKAYLASIETLSPSEKRSTGRTPNGSLRSSDEGYLTQKHASSRY 509
                                          ||:..|
  Rat   253 ------------------------------TLTVLE----------------------------- 258

  Fly   510 SLNENIFMAKHTTPSISNLKVNGLRHNSVDILSEDMHCYYSKDETFALLEPSRRIRPTVIAIPEQ 574
                                      |.::
  Rat   259 --------------------------NQIE----------------------------------- 262

  Fly   575 EQSVNSELATRRARLDSITGIRRLSRSKKPSHHRSNLRRNISIRNSNFLKDMRIHRNSIHYRGAM 639
                  |::||.                                          |||.
  Rat   263 ------EISTRP------------------------------------------HRNR------- 272

  Fly   640 LNTHRYRLRASSCPNIYRNSMTTIAKEEEDTWYDNFVDTMKSIFDFSLFLDMKFALFNLSTLFLF 704
                         |.:..|..|  .|::..:|     :..:.:.|.|||.:..|.:|..|.|...
  Rat   273 -------------PLLMSNDKT--YKKKFVSW-----NCKEKLLDISLFRNPFFYIFTWSFLLSQ 317

  Fly   705 IWFIIPYLYLPDYMKQYKYDVSQSAELISDVGIAQTVGMIGLGYLGDLSWMNINICYSLCMLVCG 769
            :.:.||..:|....|....|:..::.|:|..||.:||..:..|::.|.:|:.....:...:::||
  Rat   318 LAYFIPTFHLVARAKTLGIDIMDASYLVSVAGITETVSQLISGWIADQNWIKKYQYHKAYLILCG 382

  Fly   770 ASVFFMPLLITNYMGLMVMCVIFGFTFASSFSFTPSILVSIVDLDDFTCAY---GLVLLVQGVGM 831
            .:....||..|  ..|::...||...||.  .:...||..:|||...:..:   |......|:.:
  Rat   383 VTNLLAPLATT--FPLLMAYTIFFAIFAG--GYLALILPVLVDLSKNSRVHRFLGYASFFAGMAV 443

  Fly   832 IAGPPIAGVIYEYTGRWDDTFYYAGIFIALSGVCSYLIEFCEKKAPKESD 881
            ::||||||.||:||..:..:||::|....||.|..:.:...|:...|:||
  Rat   444 LSGPPIAGWIYDYTQTYVGSFYFSGTCYILSSVSLFFVPLAERWKLKQSD 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
chk	NP_610230.3	MFS_MCT_SLC16	138..>315	CDD:340910	57/176 (32%)
		MFS	<687..869	CDD:475125	53/184 (29%)
Slc16a4	NP_001013935.1	MFS_MCT5	20..486	CDD:340979	147/742 (20%)