Protein Alignment chk and Slc16a12

DIOPT Version :9

• Sequence 1: NP_001163063.1
• Gene: chk / 35578
• FlyBaseID: FBgn0033095
• Length: 894
• Species: Drosophila melanogaster
• Sequence 2: NP_766426.1
• Gene: Slc16a12 / 240638
• MGIID: 2147716
• Length: 486
• Species: Mus musculus
• Alignment Length: 760
• Identity: 142/760 - (18%)
• Similarity: 240/760 - (31%)
• Gaps: 334/760 - (43%)

  Fly   133 PDGGYGWVVVFASLVVSLIADGLSFSFGLINVELLEYFGESTSKTAWISSLFFSVPLLMGPIWSN 197
            ||||:||::|....:|::....::....:..||...||.:..|:||||.|:...:.:|..|:.|.
Mouse    13 PDGGWGWMIVAGCFLVTICTRAVTRCISIFFVEFQTYFAQDYSQTAWIHSIVDCMTMLCAPLGSV 77

  Fly   198 LVDKYGCRKMTILGGVVSAFGFALSSFCNSIEMLMVTFGIISGLGLGIGYVTAVVSIAFWFDKKR 262
            :.::..|:...:|||::::.||.|.||..|::.|.::.|:::|||..:.|..|:..:..:|.:::
Mouse    78 VSNQLSCQAGIMLGGLLASTGFILGSFATSLKHLYLSLGVLTGLGFALCYSPAIAMVGKYFSRRK 142

  Fly   263 TFATGIGASGTGIGTFVYARLTSYLIESYGWRGATLILGGTMLNACVCGALMRDPDWLIEENRLE 327
            ..|.||..||:|||||:.|.:...|||.:.||||.|||||.:||.||||||||
Mouse   143 ALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMR------------ 195

  Fly   328 SRSQSVTTFSNSSVCLEEIKKLLDTGITKEAVLDSLVTKNNTEANQQIDDPLDSALKRYRSEIFL 392
                        .:.|:|.:              |:..||:...:|:.|
Mouse   196 ------------PITLKEDR--------------SVPEKNHNRESQRED---------------- 218

  Fly   393 PTFLSTQELDSICEVKSLSRRSLRHKEGEEAPSRENLLSMSSGAGAYPPSTAVIGSPDDTLMGGI 457
                        |:                            .|..|.|
Mouse   219 ------------CK----------------------------QASPYSP---------------- 227

  Fly   458 AHEAAEEAKKAYLASIETLSPSEKRSTGRTPNGSLRSSDEGYLTQKHASSRYSLNENIFMAKHTT 522
                                                      ||::...:|
Mouse   228 ------------------------------------------LTKECTETR-------------- 236

  Fly   523 PSISNLKVNGLRHNSVDILSEDMHCYYSKDETFALLEPSRRIRPTVIAIPEQEQSVNSELATRRA 587
                                  :.|...::..|.|:
Mouse   237 ----------------------LCCSLQQEYGFLLM----------------------------- 250

  Fly   588 RLDSITGIRRLSRSKKPSHHRSNLRRNISIRNSNFLKDMRIHRNSIHYRGAMLNTHRYRLRASSC 652
                                            |:|:
Mouse   251 --------------------------------SDFV----------------------------- 254

  Fly   653 PNIYRNSMTTIAKEEEDTWYDNFVDTMKSIFDFSLFLDMKFALFNLSTLFLFIWFIIPYLYLPDY 717
                                             .|.:.:.|..:..|.||:   :::||
Mouse   255 ---------------------------------VLAVSVLFMAYGCSPLFV---YLVPY------ 277

  Fly   718 MKQYKYDVS--QSAELISDVGIAQTVGMIGLGYLGDLSWM-NIN-ICYSLCMLVCGASVFFMPLL 778
              .....||  |:|.|:|.:|:...||.|..|:|.|...: |.. :||...:.:.|.....:|:|
Mouse   278 --ALSVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKNYRYVCYLFAVALDGLCYLCLPML 340

  Fly   779 ITNYMGLMVMCVIFGFTFASSFSFTPSILVSIVDLDDFTCAYGLVLLVQGVGMIAGPPIAGVIYE 843
            .|..:.:...|. ||:...:..:..|.:...||.....:.|.|:|..:..|..:..|||||.:.:
Mouse   341 QTFPLLVPFSCT-FGYFDGAYVTLIPVVTAEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGWLVD 404

  Fly   844 YTGRWDDTFYYAGIFIALSGVCSYLIEFCEK----KAP---KESD 881
            .||.:...|...|..:..|.:....:...::    :.|   |:||
Mouse   405 TTGSYTAAFLLCGFAMIFSSILLGFVRIVKRMKRTQVPFPVKDSD 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
chk	NP_001163063.1	MFS	143..>315	CDD:119392	63/171 (37%)
		MFS	<685..869	CDD:119392	47/187 (25%)
Slc16a12	NP_766426.1	MFS_MCT12	18..431	CDD:340982	134/735 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I6905
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	285	1.000	Inparanoid score	I2828
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	1	1.000	-	-		mtm8713
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X70
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.860