Protein Alignment chk and Slc16a2

DIOPT Version :10

• Sequence 1: NP_610230.3
• Gene: chk / 35578
• FlyBaseID: FBgn0033095
• Length: 894
• Species: Drosophila melanogaster
• Sequence 2: NP_033223.2
• Gene: Slc16a2 / 20502
• MGIID: 1203732
• Length: 545
• Species: Mus musculus
• Alignment Length: 770
• Identity: 118/770 - (15%)
• Similarity: 216/770 - (28%)
• Gaps: 352/770 - (45%)

  Fly   133 PDGGYGWVVVFASLVVSLIADGLSFSFGLINVELLEYFGESTS----KTAWISSLFFSVPLLMGP 193
            |:||:||:||||:...:....|:..|.|::...|||...|...    :.||:.:|...:.....|
Mouse   101 PEGGFGWIVVFAATWCNGSIFGIHNSVGILYSMLLEEEKEKNRQVEFQAAWVGALAMGMIFFCSP 165

  Fly   194 IWSNLVDKYGCRKMTILGGVVSAFGFALSSFCNSIEMLMVTFGIISGLGLGIGYVTAVVSIAFWF 258
            |.|...|:.|||.....|..|:..|...|||.:|:.:...|:||:.|.|....:..::|.:..:|
Mouse   166 IVSIFTDRLGCRITATTGAAVAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLVILGHYF 230

  Fly   259 DKKRTFATGIGASGTGIGTFVYARLTSYLIESYGWRGATLILGGTMLNACVCGALMRDPDWLIEE 323
            .::...|.|:.::|:.|    ::....:||:..|                             ::
Mouse   231 QRRLGLANGVVSAGSSI----FSMSFPFLIKMLG-----------------------------DK 262

  Fly   324 NRLESRSQSVTTFSNSSVCLEEIKKLLDTGITKEAVLDSLVTKNNTEANQQIDDPLDSALKRYRS 388
            .:|....|.::||
Mouse   263 IKLAQTFQVLSTF---------------------------------------------------- 275

  Fly   389 EIFLPTFLSTQELDSICEVKSLSRRSLRHKEGEEAPSRENLLSMSSGAGAYPPSTAVIGSPDDTL 453
             :|:.|.||.
Mouse   276 -MFVLTLLSL------------------------------------------------------- 284

  Fly   454 MGGIAHEAAEEAKKAYLASIETLSPSEKRSTGRTPNGSLRSSDEGYLTQKHASSRYSLNENIFMA 518
                                                                             
Mouse   285 ----------------------------------------------------------------- 284

  Fly   519 KHTTPSISNLKVNGLRHNSVDILSEDMHCYYSKDETFALLEPSRRIRPTVIAIPEQEQSVNSELA 583
                                               |:..|.||.:..|
Mouse   285 -----------------------------------TYRPLLPSSQDTP----------------- 297

  Fly   584 TRRARLDSITGIRRLSRSKKPSHHRSNLRRNISIRNSNFLKDMRIHRNSIHYRGAMLNTHRYRLR 648
                             ||:.:|   .||:...::...:. :||:.|.           ..||:.
Mouse   298 -----------------SKRGAH---TLRQRFLVQFRKYF-NMRVFRQ-----------RTYRIW 330

  Fly   649 ASSCPNIYRNSMTTIAKEEEDTWYDNFVDTMKSIFDFSLFLDMKFALFNLSTLFLFIWFIIPYLY 713
            |                                              |.::...|  .:.:||::
Mouse   331 A----------------------------------------------FGIAAAAL--GYFVPYVH 347

  Fly   714 LPDYMKQYKYDVSQSAELISDVGIAQTVGMIGLGYLGD----LSWMNINICYSLCMLVCGASVFF 774
            |..|::....::.::..|:..:|....:|.:..|::.|    |..:.:.:   |..|:.|.....
Mouse   348 LMKYVEDKFKEIKETWVLLVCIGATSGLGRLVSGHISDSIPGLKKIYLQV---LSFLLLGLMSMM 409

  Fly   775 MPLLITNYMGLMVMCVIFGFTFASSFSFTPSILVSIVDLDDFTCAYGLVLLVQGVGMIAGPPIAG 839
            :| |..::.||:|:|:..|.......:....|...:|.....:.|.|.:|.:..:.|||||||||
Mouse   410 IP-LCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQASQAIGYLLGMMALPMIAGPPIAG 473

  Fly   840 VIYEYTGRWDDTFYYAGIFIALSGVCSYLIEFCEKKAPKESDSDVLETKKAQLLH 894
            ::....|.:...||:||:...:..|..:.:....::..|:...|  .:|...|.|
Mouse   474 LLRNCFGDYHVAFYFAGVPPIIGAVILFFVPLMHQRMFKKEQRD--SSKDKMLSH 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
chk	NP_610230.3	MFS_MCT_SLC16	138..>315	CDD:340910	44/180 (24%)
		MFS	<687..869	CDD:475125	42/185 (23%)
Slc16a2	NP_033223.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..98
		2 X 22 AA approximate tandem repeats	29..72
		MFS_MCT8_10	106..504	CDD:340978	110/739 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	514..545		4/15 (27%)