DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment chk and Slc16a2

DIOPT Version :9

Sequence 1:	NP_001163063.1	Gene:	chk / 35578	FlyBaseID:	FBgn0033095	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_033223.2	Gene:	Slc16a2 / 20502	MGIID:	1203732	Length:	545	Species:	Mus musculus

Alignment Length:	770	Identity:	118/770 - (15%)
Similarity:	216/770 - (28%)	Gaps:	352/770 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 PDGGYGWVVVFASLVVSLIADGLSFSFGLINVELLEYFGESTS----KTAWISSLFFSVPLLMGP 193
            |:||:||:||||:...:....|:..|.|::...|||...|...    :.||:.:|...:.....|
Mouse   101 PEGGFGWIVVFAATWCNGSIFGIHNSVGILYSMLLEEEKEKNRQVEFQAAWVGALAMGMIFFCSP 165

  Fly   194 IWSNLVDKYGCRKMTILGGVVSAFGFALSSFCNSIEMLMVTFGIISGLGLGIGYVTAVVSIAFWF 258
            |.|...|:.|||.....|..|:..|...|||.:|:.:...|:||:.|.|....:..::|.:..:|
Mouse   166 IVSIFTDRLGCRITATTGAAVAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLVILGHYF 230

  Fly   259 DKKRTFATGIGASGTGIGTFVYARLTSYLIESYGWRGATLILGGTMLNACVCGALMRDPDWLIEE 323
            .::...|.|:.::|:.|    ::....:||:..|                             ::
Mouse   231 QRRLGLANGVVSAGSSI----FSMSFPFLIKMLG-----------------------------DK 262

  Fly   324 NRLESRSQSVTTFSNSSVCLEEIKKLLDTGITKEAVLDSLVTKNNTEANQQIDDPLDSALKRYRS 388
            .:|....|.::||
Mouse   263 IKLAQTFQVLSTF---------------------------------------------------- 275

  Fly   389 EIFLPTFLSTQELDSICEVKSLSRRSLRHKEGEEAPSRENLLSMSSGAGAYPPSTAVIGSPDDTL 453
             :|:.|.||.
Mouse   276 -MFVLTLLSL------------------------------------------------------- 284

  Fly   454 MGGIAHEAAEEAKKAYLASIETLSPSEKRSTGRTPNGSLRSSDEGYLTQKHASSRYSLNENIFMA 518

Mouse   285 ----------------------------------------------------------------- 284

  Fly   519 KHTTPSISNLKVNGLRHNSVDILSEDMHCYYSKDETFALLEPSRRIRPTVIAIPEQEQSVNSELA 583
                                               |:..|.||.:..|
Mouse   285 -----------------------------------TYRPLLPSSQDTP----------------- 297

  Fly   584 TRRARLDSITGIRRLSRSKKPSHHRSNLRRNISIRNSNFLKDMRIHRNSIHYRGAMLNTHRYRLR 648
                             ||:.:|   .||:...::...:. :||:.|.           ..||:.
Mouse   298 -----------------SKRGAH---TLRQRFLVQFRKYF-NMRVFRQ-----------RTYRIW 330

  Fly   649 ASSCPNIYRNSMTTIAKEEEDTWYDNFVDTMKSIFDFSLFLDMKFALFNLSTLFLFIWFIIPYLY 713
            |                                              |.::...|  .:.:||::
Mouse   331 A----------------------------------------------FGIAAAAL--GYFVPYVH 347

  Fly   714 LPDYMKQYKYDVSQSAELISDVGIAQTVGMIGLGYLGD----LSWMNINICYSLCMLVCGASVFF 774
            |..|::....::.::..|:..:|....:|.:..|::.|    |..:.:.:   |..|:.|.....
Mouse   348 LMKYVEDKFKEIKETWVLLVCIGATSGLGRLVSGHISDSIPGLKKIYLQV---LSFLLLGLMSMM 409

  Fly   775 MPLLITNYMGLMVMCVIFGFTFASSFSFTPSILVSIVDLDDFTCAYGLVLLVQGVGMIAGPPIAG 839
            :| |..::.||:|:|:..|.......:....|...:|.....:.|.|.:|.:..:.|||||||||
Mouse   410 IP-LCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQASQAIGYLLGMMALPMIAGPPIAG 473

  Fly   840 VIYEYTGRWDDTFYYAGIFIALSGVCSYLIEFCEKKAPKESDSDVLETKKAQLLH 894
            ::....|.:...||:||:...:..|..:.:....::..|:...|  .:|...|.|
Mouse   474 LLRNCFGDYHVAFYFAGVPPIIGAVILFFVPLMHQRMFKKEQRD--SSKDKMLSH 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chk	NP_001163063.1	MFS	143..>315	CDD:119392	40/175 (23%)
chk	NP_001163063.1	MFS	<685..869	CDD:119392	42/187 (22%)
Slc16a2	NP_033223.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..98
		2 X 22 AA approximate tandem repeats	29..72
		2A0111	92..519	CDD:331689	115/761 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	514..545		4/15 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810